20410540 -
INTEGRATED COURSE OF BIOCHEMISTRY, MOLECULAR BIOLOGY AND MICROBIOLOGY
(objectives)
The module of General and Environmental Microbiology aims to provide the basic principles of the structure, function and evolution of microbial cells, with particular regard to bacteria. The knowledge and skills acquired in this module will represent a reference framework for understanding the role of microorganisms in natural and anthropic environments and for the study of the biotechnological applications of microorganisms for environmental protection and sustainability. The module aims at the acquisition of Cultural Competences, i.e. basic knowledge, on (i) the structural, functional and metabolic diversity present in the microbial world, (ii) the mechanisms responsible for the structure and the functioning of bacterial cells, (iii) the processes driving the evolution of bacterial species, (iv) the structure, diversity and life cycles of viruses, (v) the methods and approaches for the study of microbial communities, (vi) the role and effects of microorganisms in the environment. The module also aims at the acquisition of Methodological Competences, i.e. the understanding, through both theoretical lessons and practical activities, of the scientific bases and methodological approaches for the study of bacteria in natural environments and in the laboratory, and for the characterization of complex microbial populations by culture and molecular techniques. A further aim is also the acquisition of the ability to interpret microbiological data and analyse the scientific literature to obtain information on the structure and function of microorganisms, with the final goal to understand natural or artificial events involving microorganisms. The second module of the course: Elements of Biochemistry aims to provide the basic notions related to the structure and function of biological macromolecules, enzymatic catalysis and cell metabolism. These notions are necessary for the continuation of studies on the functioning of eukaryotic and prokaryotic organisms in the context of the Degree Course. The Educational Objectives are the acquisition of cultural skills, i.e. basic knowledge about the structure and function of biological macromolecules (nucleic acids, proteins, carbohydrates, lipids) and the mechanisms that regulate the synthesis and degradation of biological macromolecules. Furthermore, the module aims to provide basic knowledge on the mechanisms by which genetic information is conserved, transmitted and expressed properties. The Educational Objectives are also the acquisition of Methodological Competences, or the acquisition, through practical laboratory activity, of the scientific and methodological bases of the most important experimental techniques in the field of Biochemistry and Molecular Biology and the acquisition, through the elaboration and display of individual papers, of the ability to find in the scientific literature information on the structure and function of biological macromolecules capable of contextualizing, analyzing and critically interpreting natural or artificial events involving biological macromolecules.
|
|
-
ELEMENTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(objectives)
The second module of the course: Elements of Biochemistry aims to provide the basic notions related to the structure and function of biological macromolecules, enzymatic catalysis and cell metabolism. These notions are necessary for the continuation of studies on the functioning of eukaryotic and prokaryotic organisms in the context of the Degree Course. The Educational Objectives are the acquisition of cultural skills, i.e. basic knowledge about the structure and function of biological macromolecules (nucleic acids, proteins, carbohydrates, lipids) and the mechanisms that regulate the synthesis and degradation of biological macromolecules. Furthermore, the module aims to provide basic knowledge on the mechanisms by which genetic information is conserved, transmitted and expressed properties. The Educational Objectives are also the acquisition of Methodological Competences, or the acquisition, through practical laboratory activity, of the scientific and methodological bases of the most important experimental techniques in the field of Biochemistry and Molecular Biology and the acquisition, through the elaboration and display of individual papers, of the ability to find in the scientific literature information on the structure and function of biological macromolecules capable of contextualizing, analyzing and critically interpreting natural or artificial events involving biological macromolecules.
-
DI MASI ALESSANDRA
( syllabus)
PROGRAM OF THE MODULE OF BIOCHEMISTRY - Prof. Alessandra di Masi Water: physical and chemical properties. Proteins: amino acids, peptide bond, primary structure, secondary structure, tertiary structure and quaternary structure, examples of structure-function relationships. Carbohydrates: monosaccharides, polysaccharides, glycoproteins. Lipids: classification of lipids, lipid bilayer. Enzymes and enzymatic catalysis: general properties of enzymes, the concept of active site and specificity, mechanisms of catalysis, Michaelis-Menten equation, enzymatic inhibition, control of enzymatic activity. Cellular bioenergetics: anabolism and catabolism, transfer of phosphoric groups and ATP, biological redox reactions. Outline of the metabolism of carbohydrates, lipids, and proteins.
( reference books)
TEXTS ADOPTED IN THE MODULE OF "ELEMENTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY - D.L. Nelson and M.M. Cox, “Introduction to Lehninger's Biochemistry”, Ed Zanichelli - D. Voet, J.D. Voet, C.W. Pratt, “Principles of Biochemistry”, Ed Zanichelli. - M. K. Campbell, S. O. Farrell, O. M. McDougal "Biochimica", Ed. Edises
Lessons will be also provided.
Prof. Alessandra di Masi receives by appointment on Mondays from 9 to 10 am. Please fix an appointment by email (alessandra.dimasi@uniroma3.it).
-
GALLO VALENTINA
( syllabus)
The Course aims to provide students with basic knowledge relating to biochemistry and cellular metabolism. Carbohydrates, Lipids, Amino acids, proteins: structure of proteins and examples of structure-function relationships. Enzymes and enzymatic catalysis: Definition of active site and substrate specificity; the Michaelis-Menten equation, enzyme inhibition. Introduction to aerobic and anaerobic metabolism. Metabolism of carbohydrates, lipids and nitrogen compounds. Energy production in mitochondria.
The Course also aims to provide basic knowledge of molecular biology. Purine and pyrimidine nucleotides; structure of biological macromolecules; structure of eukaryotic chromosomes; Replication, Transcription; Translation; Recombinant DNA and Genetically modified organisms.
( reference books)
Nelson, Cox Introduzione alla biochimica di Lehninger - Zanichelli
Stefani-Taddei, Chimica, Biochimica e Biologia Applicata- Zanichelli
Chimica e Biochimica, a cura di Samaja e Paroni - Piccin
Elementi di Biologia e Genetica, a cura di Raven et al. - Piccin
Lecture notes and calculation exercises will be provided.
|
3
|
BIO/10
|
24
|
-
|
-
|
-
|
Core compulsory activities
|
3
|
BIO/11
|
24
|
-
|
-
|
-
|
Core compulsory activities
|
|
ITA |
20410536 -
CELL BIOLOGY AND GENETIC ELEMENTS
(objectives)
The course aims to provide basic knowledge on the morpho-functional organization of animal cells and tissues, with particular attention to mammals. In addition, the students will be provided with the theoretical and practical skills for understanding the fundamental mechanisms of both Mendelian and non-Mendelian inheritance of characters and of environmental mutagenesis. The course also aims to provide students with basic knowledge relating to the development and anatomy of vertebrates from an evolutionary point of view. The basic information for understanding the differentiation and morphogenesis processes will be provided. The students will acquire basic knowledge on animal cells and tissues, on formal genetics and environmental mutagenesis for understanding chromosomal aberrations and, finally, on the general principles of animal development, from gametogenesis to organ formation. The students will also acquire the theoretical and practical skills necessary for the recognition at the macro- and microscopic level of anatomical and embryonic structures of vertebrates.
-
COLASANTI MARCO
( syllabus)
The course is divided into 3 modules: (1) Cytology and Histology. Stem cells, differentiation and cell death; plasma membrane and membrane transport; DNA, nucleus, cell cycle, mitosis and meiosis; cellular organelles, proteins, cytoplasmic pathway, secretory pathway, vesicular trafficking; mitochondria and energy; cytoskeleton; cellular junctions; epithelial tissue; nerve tissue; muscle tissue; connective tissue; bone tissue; Blood; immunity. (2) Elements of Genetics. Basic elements of genetics: organization of chromatin, hetero and euchromatin, the gene, the allele. The chromosome: structure and function. Homologous chromosomes, sister chromatids. Cell division: mitosis and meiosis. Defects of cell division and its consequences. Mendel and the concept of gene. Mendel's laws, numerical exercises. Extension of Mendelian genetics (incomplete dominance, codominance, multiple alleles, pleiotropy, epistasis). The chromosomal basis of inheritance, X-linked characters, crossing over and linkage maps, two-point cross, three-point cross, numerical exercises. Basic concepts of population genetics, numerical exercises. The molecular basis of heredity, semi-conservative DNA replication. Numerical and structural chromosomal aberrations. (3) Developmental Biology and Comparative Anatomy. (Developmental Biology). From a single cell to a multicellular organism: differentiation and morphogenesis. Sexual reproduction. Gametogenesis. Structural differences between the egg and the sperm. Fertilization: recognition of gametes at a distance and by contact. General information on the various stages of development: segmentation, gastrulation, organogenesis. Protostomes and deuterostomes. Early stages of development of echinoderms, cephalochordates, amphibians, birds, and mammals. Neurulation and the formation of encephalic vesicles. The mesoderm and the fate of the regions into which it is divided. The extraembryonic annexes: amnios, chorion, allantoid and yolk sac. The placenta. (Comparative Anatomy). Origin of vertebrates. The first agnates and the appearance of gnathostomes. Diversity and evolutionary success of aquatic vertebrates read based on their anatomy and reproductive biology. Origin of tetrapods and conquest of the emerged lands. Chondroichthyes, osteichthyes, amphibians, reptiles, birds and mammals. Comparative anatomy of the organic systems of vertebrates: integumentary, respiratory, digestive and circulatory and uro-genital systems.
( reference books)
1) Cytology and Histology: Miscellaneous authors. Biologia - Cellula e Tessuti, Colombo&Olmo eds, edi-ermes. / E. Ginelli, M. Malcovati - Molecole, Cellule e Organismi, EdiSES 2) Elements of Genetics: Campbell. Biologia e genetica, Urry, Cain, Wasserman, Minorsky and Orr. Pearson 3) Developmental Biology: Menegola et al. "Manuale di Biologia dello Sviluppo Animale", EdiSES 4) Comparative anatomy: Stingo "Anatomia Comparata", Edi-Ermes
-
CIANFANELLI VALENTINA
( syllabus)
The course is divided into 3 modules: (1) Cellular biology – Prof. Marco Colasanti Stem cells, differentiation and cell death; plasma membrane and membrane transport; DNA, nucleus, cell cycle, mitosis and meiosis; cellular organelles, proteins, cytoplasmic pathway, secretory pathway, vesicular trafficking; mitochondria and energy; cytoskeleton; cellular junctions; elements of histology. (2) Elements of Genetics – Prof. Antonella Sgura/Dr. Francesco Berardinelli Basic elements of genetics: organization of chromatin, hetero and euchromatin, the gene, the allele. The chromosome: structure and function. Homologous chromosomes, sister chromatids. Cell division: mitosis and meiosis. Defects of cell division and its consequences. Mendel and the concept of gene. Mendel's laws, numerical exercises. The chromosomal basis of inheritance, X-linked characters, numerical exercises(3) Developmental Biology/Comparative Anatomy – Dr. Valentina Cianfanelli General principles of developmental biology and comparative anatomy. Classification, General characters and phylogenetic relationships among the main taxa of vertebrates. From a single cell to a multicellular organism: differentiation and morphogenesis. Sexual reproduction. Gametes. Fecundation: recognition of gametes at a distance and by contact. General information on the various stages of development: segmentation, gastrulation, organogenesis. Protostomes and deuterostomes. Comparing the stages of development in echinoderms, amphibians, birds, and mammals. Germ layers. Neurulation. Organogenesis. Comparative anatomy of the organic systems of vertebrates. Eco-Devo: environment and developmental biology.
( reference books)
1) Cytology and Histology: (1) Miscellaneous authors. Biologia - Cellula e Tessuti, Colombo&Olmo eds, edi-ermes; (2) Molecole, Cellule e Organismi - Coordination by: E. Ginelli, M. Malcovati. EdiSES
2) Elements of Genetics: Campbell. Biologia e genetica, Urry, Cain, Wasserman, Minorsky and Orr. Pearson
3) Developmental Biology: Menegola et al. "Manuale di Biologia dello Sviluppo Animale", EdiSES
4) Comparative anatomy: Giavini, Menegola, “Manuale di Anatomia Comparata”, EdiSES
-
SGURA ANTONELLA
( syllabus)
plasma membrane and membrane transport; DNA, nucleus, cell cycle, mitosis and meiosis; cellular organelles, proteins, cytoplasmic pathway, secretory pathway, vesicular trafficking; mitochondria and energy; cytoskeleton; cellular junctions; epithelial tissue; nerve tissue; muscle tissue; connective tissue; bone tissue; Blood; immunity. (2) Elements of Genetics. Basic elements of genetics: organization of chromatin, hetero and euchromatin, the gene, the allele. The chromosome: structure and function. Homologous chromosomes, sister chromatids. Cell division: mitosis and meiosis. Defects of cell division and its consequences. Mendel and the concept of gene. Mendel's laws, numerical exercises. Extension of Mendelian genetics (incomplete dominance, codominance, multiple alleles, pleiotropy, epistasis). The chromosomal basis of inheritance, X-linked characters, crossing over and linkage maps, two-point cross, three-point cross, numerical exercises. Basic concepts of population genetics, numerical exercises. The molecular basis of heredity, semi-conservative DNA replication. Numerical and structural chromosomal aberrations. (3) Developmental Biology and Comparative Anatomy. (Developmental Biology). From a single cell to a multicellular organism: differentiation and morphogenesis. Sexual reproduction. Gametogenesis. Structural differences between the egg and the sperm. Fertilization: recognition of gametes at a distance and by contact. General information on the various stages of development: segmentation, gastrulation, organogenesis. Protostomes and deuterostomes. Early stages of development of echinoderms, cephalochordates, amphibians, birds, and mammals. Neurulation and the formation of encephalic vesicles. The mesoderm and the fate of the regions into which it is divided. The extraembryonic annexes: amnios, chorion, allantoid and yolk sac. The placenta. (Comparative Anatomy). Origin of vertebrates. The first agnates and the appearance of gnathostomes. Diversity and evolutionary success of aquatic vertebrates read based on their anatomy and reproductive biology. Origin of tetrapods and conquest of the emerged lands. Chondroichthyes, osteichthyes, amphibians, reptiles, birds and mammals. Comparative anatomy of the organic systems of vertebrates: integumentary, respiratory, digestive and circulatory and uro-genital systems.
( reference books)
1) Cytology and Histology: Miscellaneous authors. Biologia - Cellula e Tessuti, Colombo&Olmo eds, edi-ermes. 2) Elements of Genetics: Campbell. Biologia e genetica, Urry, Cain, Wasserman, Minorsky and Orr. Pearson 3) Developmental Biology: Menegola et al. "Manuale di Biologia dello Sviluppo Animale", EdiSES 4) Comparative anatomy: Stingo "Anatomia Comparata", Edi-Ermes
-
BERARDINELLI FRANCESCO
( syllabus)
Inglese The course is divided into 3 modules: (1) Cellular biology– Prof. Marco Colasanti Stem cells, differentiation and cell death; plasma membrane and membrane transport; DNA, nucleus, cell cycle, mitosis and meiosis; cellular organelles, proteins, cytoplasmic pathway, secretory pathway, vesicular trafficking; mitochondria and energy; cytoskeleton; cellular junctions; elements of histology. (2) Elements of Genetics – Prof. Antonella Sgura/Dr. Francesco Berardinelli Basic elements of genetics: organization of chromatin, hetero and euchromatin, the gene, the allele. The chromosome: structure and function. Homologous chromosomes, sister chromatids. Cell division: mitosis and meiosis. Defects of cell division and its consequences. Mendel and the concept of gene. Mendel's laws, numerical exercises.The chromosomal basis of inheritance, X-linked characters, numerical exercises. (3) Developmental Biology/Comparative Anatomy – Dr. Valentina Cianfanelli General principles of developmental biology and comparative anatomy. Classification, General characters and phylogenetic relationships among the main taxa of vertebrates. From a single cell to a multicellular organism: differentiation and morphogenesis. Sexual reproduction. Gametes. Fecundation: recognition of gametes at a distance and by contact. General information on the various stages of development: segmentation, gastrulation, organogenesis. Protostomes and deuterostomes. Comparing the stages of development in echinoderms, amphibians, birds, and mammals. Germ layers. Neurulation. Organogenesis. Comparative anatomy of the organic systems of vertebrates. Eco-Devo: environment and developmental biology.
( reference books)
1) Cytology and Histology: (1) Miscellaneous authors. Biologia - Cellula e Tessuti, Colombo&Olmo eds, edi-ermes; (2) Molecole, Cellule e Organismi - Coordination by: E. Ginelli, M. Malcovati. EdiSES 2) Elements of Genetics: Campbell. Biologia e genetica, Urry, Cain, Wasserman, Minorsky and Orr. Pearson 3) Developmental Biology: Menegola et al. "Manuale di Biologia dello Sviluppo Animale", EdiSES 4) Comparative anatomy: Giavini, Menegola, “Manuale di Anatomia Comparata”, EdiSES
|
|
ITA |