Course
|
Credits
|
Scientific Disciplinary Sector Code
|
Contact Hours
|
Exercise Hours
|
Laboratory Hours
|
Personal Study Hours
|
Type of Activity
|
Language
|
20410538 -
ORGANIC CHEMISTRY
(objectives)
The course aims to provide students with the knowledge necessary to deeply understand chemical structures, physical properties, preparations, and typical reactivity of organic compounds throughout the study of the most common functional groups. The inherent target is to highlight the role and the effect of Organic Chemistry in Natural Sciences and modern technology with particular attention to biological and naturalistic aspects as well as to problems concerning pollution and environmental sustainability. In this area, the acquired knowledge will play a crucial role in the study of the other disciplines envisaged in the CdS (Biochemistry, Physiology, Genetics). At the end of the course, the students should develop the skill and expertise to (1) recognise and comprehend the structural and physical properties of organic compounds, (2) autonomously understand and analyse the reactivity of the main classes of biomolecules, (3) use a suitable technical-scientific language in order to clearly explain and present the acquired concepts as well as to disseminate ideas, information, and explanations.
-
GASPERI TECLA
( syllabus)
Cultural skills (Knowledge of): The course aims to provide the student with the chemical basis of the structure, properties, and reactivity of organic molecules, as well as with the main notions for understanding the logic and principles that regulate the chemistry of natural complex systems. Methodological skills (How to carry out): At the end of the course, the student will be able to analyse and discuss the mechanism of the main reactions underlying Organic Chemistry, as well as to understand the importance of Organic Chemistry applied to the study of natural systems and to the development of biologically active molecules 1.Introduction to Organic Chemistry: Organic chemistry around us; Organic compounds; Functional groups; How molecules are written; Introduction to nomenclature. 2. Structure of molecules: The atomic structure. The Atomic Orbitals. Lewis's formulas; The chemical bond. The covalent bond. Three-dimensional structure and hybridization. Types of covalent bonds and Molecular Orbitals. The main elements and their links. The ionic bond. Electronegativity. Polarity of the bond and Resonance (I). Bond energy and length. 3. Stereochemistry: structural isomers. stereoisomerism; cis-trans stereoisomerism. 4. Acidity, Basicity and pKa: Solubility of organic compounds in water; pKa (definition and scale); Acidity and basicity of nitrogen compounds; Carbon acidity; Lewis acids and bases. 5. Reactivity in Organic Chemistry: Reactive species; method of breaking the chemical bond; resonance (II) and delocalization formulas; the main reactive species; electronic structure (delocalization) and stability of radicals, carbocations and carbanions; nucleophiles and electrophiles; reactions and mechanisms; catalysis; classification of reactions. 6. Nucleophilic Substitution. (SN1, SN2). Eliminations. 7. Nucleophilic Addition to Carbonyl: molecular orbitals explain the reactivity of the carbonyl; nucleophilic attack on aldehydes and ketones; hemiacetals, acetals, introduction to carbohydrates. Imines, Enamines 8. Nucleophilic Carbonyl Substitution: Carboxylic acids and derivatives; Property. Carboxylic acids (Fatty acids and soaps), Esters (Flavours, Waxes, Triglycerides, Phospholipids), Amides (Amino acids, Peptides, Proteins), Urea. Acyl halides, Anhydrides. Mechanism of Nucleophilic Acyl Substitution; Preparation of Acyl Halides, Esters and Amides. 9. Aromatic and heterocyclic compounds. Aromaticity. Benzene and arenes. Polycyclic aromatic hydrocarbons. Phenols: Acid Properties, Natural Polyphenols: Anthocyanins, Flavonoids, Gallic and Flavanolic Tannins. Aniline: Basic Properties 10. Heterocyclic compounds of biological and environmental importance. Pyridine, Pyrimidine, Purine. Tautomerie in hydroxy heterocycles. Nucleotides: Nitrogen bases, nucleosides and nucleotides, DNA / RNA, ATP / ADP / AMP, NAD and FAD.
( reference books)
T.W. Graham Solomons; Craig B. Fryhle in “Organic Chemistry”, 10th Edition, Wiley. John McMurry in “Chimica Organica”, Piccin-Nuova Libreria Bruno Botta in “Chimica Organica” Edi-ermes
Lecture notes and bibliographical references will be provided
The teacher receives Tuesday from 17.00 to 19.00 by appointment via e-mail: tecla.gasperi@uniroma3.it
|
6
|
CHIM/06
|
40
|
-
|
10
|
-
|
Basic compulsory activities
|
ITA |
20410540 -
INTEGRATED COURSE OF BIOCHEMISTRY, MOLECULAR BIOLOGY AND MICROBIOLOGY
(objectives)
The module of General and Environmental Microbiology aims to provide the basic principles of the structure, function and evolution of microbial cells, with particular regard to bacteria. The knowledge and skills acquired in this module will represent a reference framework for understanding the role of microorganisms in natural and anthropic environments and for the study of the biotechnological applications of microorganisms for environmental protection and sustainability. The module aims at the acquisition of Cultural Competences, i.e. basic knowledge, on (i) the structural, functional and metabolic diversity present in the microbial world, (ii) the mechanisms responsible for the structure and the functioning of bacterial cells, (iii) the processes driving the evolution of bacterial species, (iv) the structure, diversity and life cycles of viruses, (v) the methods and approaches for the study of microbial communities, (vi) the role and effects of microorganisms in the environment. The module also aims at the acquisition of Methodological Competences, i.e. the understanding, through both theoretical lessons and practical activities, of the scientific bases and methodological approaches for the study of bacteria in natural environments and in the laboratory, and for the characterization of complex microbial populations by culture and molecular techniques. A further aim is also the acquisition of the ability to interpret microbiological data and analyse the scientific literature to obtain information on the structure and function of microorganisms, with the final goal to understand natural or artificial events involving microorganisms. The second module of the course: Elements of Biochemistry aims to provide the basic notions related to the structure and function of biological macromolecules, enzymatic catalysis and cell metabolism. These notions are necessary for the continuation of studies on the functioning of eukaryotic and prokaryotic organisms in the context of the Degree Course. The Educational Objectives are the acquisition of cultural skills, i.e. basic knowledge about the structure and function of biological macromolecules (nucleic acids, proteins, carbohydrates, lipids) and the mechanisms that regulate the synthesis and degradation of biological macromolecules. Furthermore, the module aims to provide basic knowledge on the mechanisms by which genetic information is conserved, transmitted and expressed properties. The Educational Objectives are also the acquisition of Methodological Competences, or the acquisition, through practical laboratory activity, of the scientific and methodological bases of the most important experimental techniques in the field of Biochemistry and Molecular Biology and the acquisition, through the elaboration and display of individual papers, of the ability to find in the scientific literature information on the structure and function of biological macromolecules capable of contextualizing, analyzing and critically interpreting natural or artificial events involving biological macromolecules.
|
|
-
ELEMENTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
(objectives)
The second module of the course: Elements of Biochemistry aims to provide the basic notions related to the structure and function of biological macromolecules, enzymatic catalysis and cell metabolism. These notions are necessary for the continuation of studies on the functioning of eukaryotic and prokaryotic organisms in the context of the Degree Course. The Educational Objectives are the acquisition of cultural skills, i.e. basic knowledge about the structure and function of biological macromolecules (nucleic acids, proteins, carbohydrates, lipids) and the mechanisms that regulate the synthesis and degradation of biological macromolecules. Furthermore, the module aims to provide basic knowledge on the mechanisms by which genetic information is conserved, transmitted and expressed properties. The Educational Objectives are also the acquisition of Methodological Competences, or the acquisition, through practical laboratory activity, of the scientific and methodological bases of the most important experimental techniques in the field of Biochemistry and Molecular Biology and the acquisition, through the elaboration and display of individual papers, of the ability to find in the scientific literature information on the structure and function of biological macromolecules capable of contextualizing, analyzing and critically interpreting natural or artificial events involving biological macromolecules.
-
DI MASI ALESSANDRA
( syllabus)
PROGRAM OF THE MODULE OF BIOCHEMISTRY - Prof. Alessandra di Masi Water: physical and chemical properties. Proteins: amino acids, peptide bond, primary structure, secondary structure, tertiary structure and quaternary structure, examples of structure-function relationships. Carbohydrates: monosaccharides, polysaccharides, glycoproteins. Lipids: classification of lipids, lipid bilayer. Enzymes and enzymatic catalysis: general properties of enzymes, the concept of active site and specificity, mechanisms of catalysis, Michaelis-Menten equation, enzymatic inhibition, control of enzymatic activity. Cellular bioenergetics: anabolism and catabolism, transfer of phosphoric groups and ATP, biological redox reactions. Outline of the metabolism of carbohydrates, lipids, and proteins.
( reference books)
TEXTS ADOPTED IN THE MODULE OF "ELEMENTS OF BIOCHEMISTRY AND MOLECULAR BIOLOGY - D.L. Nelson and M.M. Cox, “Introduction to Lehninger's Biochemistry”, Ed Zanichelli - D. Voet, J.D. Voet, C.W. Pratt, “Principles of Biochemistry”, Ed Zanichelli.
Lessons will be also provided.
Prof. Alessandra di Masi receives by appointment on Mondays from 9 to 10 am. Please fix an appointment by email (alessandra.dimasi@uniroma3.it).
-
ANTONINI GIOVANNI
( syllabus)
The Course aims to provide students with basic knowledge relating to biochemistry and cellular metabolism. Carbohydrates, Lipids, Amino acids, proteins: structure of proteins and examples of structure-function relationships. Enzymes and enzymatic catalysis: Definition of active site and substrate specificity; the Michaelis-Menten equation, enzyme inhibition. Introduction to aerobic and anaerobic metabolism. Metabolism of carbohydrates, lipids and nitrogen compounds. Energy production in mitochondria. The Course also aims to provide basic knowledge of molecular biology. Purine and pyrimidine nucleotides; structure of biological macromolecules: DNA and RNA; structure of eukaryotic chromosomes; Replication, Transcription; Translation; Recombinant DNA and Genetically modified organisms.
( reference books)
Nelson, Cox Introduzione alla biochimica di Lehninger - Zanichelli Stefani-Taddei, Chimica, Biochimica e Biologia Applicata- Zanichelli Chimica e Biochimica, a cura di Samaja e Paroni - Piccin Elementi di Biologia e Genetica, a cura di Raven et al. - Piccin
Lecture notes and calculation exercises will be provided
Professors receive every day by appointment by e-mail: alessandra.dimasi@uniroma3.it or giovanni.antonini@uniroma3.it
|
3
|
BIO/10
|
16
|
6
|
4
|
-
|
Core compulsory activities
|
3
|
BIO/11
|
16
|
6
|
4
|
-
|
Core compulsory activities
|
|
ITA |
-
GENERAL AND ENVIRONMENTAL MICROBIOLOGY
(objectives)
The module of General and Environmental Microbiology aims to provide the basic principles of the structure, function and evolution of microbial cells, with particular regard to bacteria. The knowledge and skills acquired in this module will represent a reference framework for understanding the role of microorganisms in natural and anthropic environments and for the study of the biotechnological applications of microorganisms for environmental protection and sustainability. The module aims at the acquisition of Cultural Competences, i.e. basic knowledge, on (i) the structural, functional and metabolic diversity present in the microbial world, (ii) the mechanisms responsible for the structure and the functioning of bacterial cells, (iii) the processes driving the evolution of bacterial species, (iv) the structure, diversity and life cycles of viruses, (v) the methods and approaches for the study of microbial communities, (vi) the role and effects of microorganisms in the environment. The module also aims at the acquisition of Methodological Competences, i.e. the understanding, through both theoretical lessons and practical activities, of the scientific bases and methodological approaches for the study of bacteria in natural environments and in the laboratory, and for the characterization of complex microbial populations by culture and molecular techniques. A further aim is also the acquisition of the ability to interpret microbiological data and analyse the scientific literature to obtain information on the structure and function of microorganisms, with the final goal to understand natural or artificial events involving microorganisms.
-
IMPERI FRANCESCO
( syllabus)
Introduction to and history of Microbiology Functional diversity and distribution of microorganisms, main discoveries in the microbiology field, examples of biotechnological applications of microorganisms.
Structure and functions of bacterial cells Structure of the prokaryotic cell. Cell division: binary fission. Cytoplasm, cytoplasmic inclusions and sub-cellular organelles. Cytoplasmic membrane and cell wall in Bacteria and Archaea. Protein secretion and cell wall biogenesis. Surface appendages: flagella and pili. Bacterial motility. Cell differentiation in bacteria and sporulation. Microbial biofilms. Bacterial metabolism: chemoorganotrophs, chemolithotrophs and phototrophs. Bacterial cultures and methods for bacterial cell count. Antibiotics: activity, mechanisms of action, evolution of resistance. Transcriptional and post-transcriptional regulation of gene expression in bacteria.
Elements of bacterial genetics Structure of the bacterial chromosome. Operons. Genome and pangenome. Mobile genetic elements: plasmids and transposable elements. Horizontal gene transfer (HGT): transformation, conjugation, transduction. Role of mutations and HGT in microbial evolution.
Principles of virology Structure of viruses and infection strategies. Diversity and replication of viral genomes. Examples of viral gene regulation. Diffusion and role of virus in the environment.
Principles of bacterial taxonomy and environmental microbiology The concept of bacterial species. Main prokaryotic groups. Bacterial identification: culture- and molecular-based approaches. Molecular clocks and phylogenetic analysis. Characterization of complex microbial communities. Metagenomic analysis and unculturable bacteria. Microbial activities in environmental processes. Interaction of microorganisms with plants, animals and other microorganisms. Role of microorganisms in biogeochemical cycling.
( reference books)
Title: Brock. Biology of microorganisms. Authors: Michael T. Madigan - John M. Martinko - David A. Stahl - Kelly S. Bender - Daniel H. Buckley. Editor: Pearson.
|
6
|
BIO/19
|
40
|
-
|
10
|
-
|
Core compulsory activities
|
ITA |
20410537 -
INTEGRATED COURSE OF MINERALOGY AND PETROGRAPHY
(objectives)
The first didactic unit (mineralogy and georesources) aims to provide the student with a basic knowledge of geological mineralogy, an introduction to the exploitation of mineral resources with the connected environmental sustainability issues, and the use of geological materials in science, art and technology. The second didactic unit (petrography) aims to provide knowledge of the behavior and properties of metamorphic and sedimentary igneous rocks in the evolution of planet Earth. The expected learning outcomes are the students’ ability to recognize and contextualize rocks and minerals in the territory, to have perception of their meaning in terms of genesis and geological evolution, and to understand their human use in the context of respect for the environment.
|
|
-
PETROGRAPHY
(objectives)
The second didactic unit (petrography) aims to provide knowledge of the behavior and properties of metamorphic and sedimentary igneous rocks in the evolution of planet Earth. The expected learning outcomes are the students’ ability to recognize and contextualize rocks and minerals in the territory, to have perception of their meaning in terms of genesis and geological evolution, and to understand their human use in the context of respect for the environment.
-
VONA ALESSANDRO
( syllabus)
PART I – THE GEOLOGICAL CONTEXT Lesson I – Composition and Structure of the Earth Lesson II – Plate Tectonics and the Rock Cycle
PART II – IGNEOUS ROCKS Lesson III – The Nature of Magma Lesson IV – Occurrence and Classification of Igneous Rocks Lesson V – Magma Generation, Ascent, and Differentiation Lesson VI – Rock Melting and Magma Crystallization Lesson VII – Volcanism
PART III – SEDIMENTARY ROCKS Lesson VIII – Sediment Formation, Transport, and Lithification Lesson IX – Classification of Sedimentary Rocks
PART IV – METAMORPHIC ROCKS Lesson X – The Metamorphic Process and Metamorphic Rocks
PART V – ROCK IDENTIFICATION IN THIN SECTION (LABORATORY OF OPTICAL PETROGRAPHY)
( reference books)
MINERALOGIA E PETROGRAFIA – C. Klein, A.R. Philpotts (Zanichelli) MATERIALE DIDATTICO (Testi, Grafici ed Esercizi) DISTRIBUITO DAL DOCENTE
|
3
|
GEO/07
|
20
|
-
|
5
|
-
|
Basic compulsory activities
|
3
|
GEO/07
|
20
|
-
|
5
|
-
|
Core compulsory activities
|
|
ITA |
20410539 -
ANIMAL BIODIVERSITY ZOOLOGY AND PROTECTION
(objectives)
This course aims to provide basic knowledge about animals and their relationships with the other organisms and the environment using an evolutionary and adaptive approach. Cultural and educational objectives of this course is the acquisition of basic knowledge on: zoological classification and systematics; structural and functional organization of animals; methods of reproduction; development; behavior; phylogeny; distribution. Other objectives are also the acquisition of methodological skills, such as the recognition of the main animal taxa, monitoring techniques, comparative analysis of macro and microscopic anatomy and the preparation of samples to be observed with optical microscopes. The expected learning outcomes concern in-depth knowledge of animal biodiversity, in order to develop an awareness of their fundamental ecological role and the need of monitoring and protection for the sake of the survival of all ecosystems
|
2
|
BIO/05
|
16
|
-
|
-
|
-
|
Basic compulsory activities
|
5
|
BIO/05
|
32
|
-
|
10
|
-
|
Core compulsory activities
|
2
|
BIO/05
|
8
|
-
|
10
|
-
|
Attività formative affini ed integrative
|
|
ITA |
Optional group:
Insegnamenti a scelta - (show)
|
|
|
|
|
|
|
|
|
|