Degree Course: Biomedical Engineering Syllabus for A.Y. 2016/2017

Italian version

FIRST YEAR

First semester

Course	Credits	Scientific Disciplinary Sector Code	Contact Hours	Exercise Hours	Laboratory Hours	Personal Study Hours	Type of Activity	Language
20810021 - BIOPHYSICS AND HUMAN PHYSIOLOGY (objectives) First Module: Let the student know the essentials elements of the structure and function of cells and tissues, and of the main organs and body systems. Second module: let the student know the fundamentals of Biochemistry.
20810021-1 - BIOPHYSICS AND HUMAN PHYSIOLOGY (MODULE 1) (objectives) Let the student know the essentials elements of the structure and function of cells and tissues, and of the main organs and body systems. - ACCONCIA FILIPPO (syllabus) Molecular and Cell Biophysics. Amino acids, protein structure, hemoglobin, myoglobin, enzymes, enzyme catalysis, enzyme activation, enzyme inhibition, carbohydrates, glycolysis, Krebs cycle, oxidative phosphorylation, lactate biosynthesis, alcoholic fermentation, lipids, beta-oxidation, amino acid and protein catabolism, urea cycle. The cell compartimentation, The energy of living organisms. Tissues organization. Membrane dynamic structure, functions and dynamics of cell plasma membranes. Junctions, channels, receptors. Permeability, diffusion, osmosys, tonicity. Plasma membrane transport systems: facilitate, primary and secondary active transport. Endocytosis-exocytosis. Ion transport. Biophysics of Homeostatic Systems: central nervous system and autonomous nervous system. Electrical properties of the cell plasma membrane, genesis of the transplasma membrane potential, excitability, resting membrane potential, electrotonic and action potential. Propagation and transmission of electric signals. Synapses. Neuronal plasticity. Somatic and autonomous reflex arc. Sensory physiology. Hormones. Cell communication, general properties of the endocrine system, chemical structure and release of hormones. Hormone signal transduction. (reference books) MAIN TEXTBOOK: D.U. SILVERTHORN Human Physiology 2010 Pearson Education inc BOOKS FOR DEEPENING KNOWLEDGE: (AVAILABLE IN THE SCIENTIFIC LIBRARY) HILL R, WYSE G, ANDERSON M FISIOLOGIA ANIMALE 2006 ZANICHELLI; RANDALL D. ET AL., FISIOLOGIA ANIMALE ZANICHELLI; CASELLA C. E TAGLIETTI V. PRINCIPI DI FISIOLOGIA ED. LA GOLIARDICA PAVESE; BERNE R.M. E LEVY M.N. PRINCIPI DI FISIOLOGIA CASA EDITRICE AMBROSIANA.	6	BIO/09	48	-	-	-	Related or supplementary learning activities	ENG
20810021-2 - BIOPHYSICS AND HUMAN PHYSIOLOGY (MODULE 2) (objectives) Let the student know the fundamentals of Biochemistry - ACCONCIA FILIPPO (syllabus) Physiology of organs and systems: muscle system. Skeletal, smooth, cardiac muscle. Mechanic of the skeletal muscle contraction. Myogram. Refractory period. Tetanic contraction. Control of the muscle contraction. Fatigue. Cardiovascular system. Electrical properties of the heart, potentials of pacemaker cells and working myocardium, the heart as a pump. Intrinsic and extrinsic regulation of the heart cardiac output. Vascular system, flux, artery pressure and its regulation. The blood. Properties, globular resistance, blood distribution to tissues. Coagulation. Respiratory system. Respiratory mechanic, ventilation, exchange and transport of gases, ph regulation, regulation of ventilation. Basis of gastro-intestinal physiology. Renal system. Glomerular filtration, reassorbtion, secretion, excretion. Hormone regulation of the renal function. Digestive system. Motility, secretion, digestion, absorption of carbohydrates, lipids and proteins. (reference books) MAIN TEXTBOOK: D.U. SILVERTHORN Human Physiology 2010 Pearson Education inc BOOKS FOR DEEPENING KNOWLEDGE: (AVAILABLE IN THE SCIENTIFIC LIBRARY) HILL R, WYSE G, ANDERSON M FISIOLOGIA ANIMALE 2006 ZANICHELLI; RANDALL D. ET AL., FISIOLOGIA ANIMALE ZANICHELLI; CASELLA C. E TAGLIETTI V. PRINCIPI DI FISIOLOGIA ED. LA GOLIARDICA PAVESE; BERNE R.M. E LEVY M.N. PRINCIPI DI FISIOLOGIA CASA EDITRICE AMBROSIANA.	3	BIO/09	24	-	-	-	Related or supplementary learning activities	ENG
20810011 - SIGNAL PROCESSING FOR BIOMEDICAL ENGINEERING (objectives) To acquire fundamental knowledges on digital operations to analyze discrete signals in biomedical environments. To link different operating blocks in one complex system for analysis and processing. To provide an overview of some typical application of biomedical signals for processing and transmission, by a short description of main operating concepts. - GIUNTA GAETANO (syllabus) Discrete signals and systems. Operations between sequences. Scale changes. Digital transforms. Filtering. Linear system analysis. Optimum filters. Digital estimators and performance. Prediction. Spectral estimators. Applications of telemedicine. Digital health systems. Laboratory of numerical examples by MatLab platform. (reference books) G. Giunta, Slides of Signal Processing for Biomedical Engineering, edition 2015. TAMAL BOSE, FRANCOIS MEYER, "DIGITAL SIGNAL AND IMAGE PROCESSING", DECEMBER 2003, WILEY PUBL. A.V. OPPENHEIM, R.W. SHAFER, J.R. BUCK, "DISCRETE-TIME SIGNAL PROCESSING", PRENTICE-HALL, UPPER SADDLE RIVER, NJ (USA), 1999. B. Fong, A.C.M. Fong, C.K. Li, Telemedicine Technologies, Wiley, 2011.	6	ING-INF/03	48	-	-	-	Related or supplementary learning activities	ENG
20810022 - FUNDAMENTALS OF BIOMEDICAL ENGINEERING (objectives) The aim is the development o f the specific competencies for the study of the biological systems from the bioengineering point of view. The presented approach deals with the chain biological system-model-measurement and is devoted to specific applications such as the diagnosis, the therapy, the rehabilitation, the ergonomics and the sport medicine. The aim is the acquisition of the competencies for the use of the biomedical instrumentation contained in a human movement laboratory. The students will be exposed to the main hardware and software tools needed to i) design measurement chains, ii) define the population under exam, iii) extract the information from the recorded data.
20810022-1 - FUNDAMENTALS OF BIOMEDICAL ENGINEERING (MODULE 1) (objectives) The aim is the development o f the specific competencies for the study of the biological systems from the bioengineering point of view. The presented approach deals with the chain biological system-model-measurement and is devoted to specific applications such as the diagnosis, the therapy, the rehabilitation, the ergonomics and the sport medicine. The aim is the acquisition of the competencies for the use of the biomedical instrumentation contained in a human movement laboratory. The students will be exposed to the main hardware and software tools needed to i) design measurement chains, ii) define the population under exam, iii) extract the information from the recorded data. - CONFORTO SILVIA (syllabus) Introduction to the Biomedical Engineering in general and to this course in particular. Acquisition of biomedical signals. The Movement Analysis Lab. Kinematics, Kinetics and Electrophysiology of human movement. Statistical analysis: descriptive statistics, inferential statistics. Design and realization of a 3 components force plate. Biolab3 iPED: an integrated wireless system to evaluate athlete performances during cycling (reference books) • BRONZINO - BIOMEDICAL ENGINEERING HANDBOOK, TAYLOR AND FRANCIS GROUP • ONLINE TUTORIALS ON moodle2 web platform	6	ING-INF/06	48	-	-	-	Core compulsory activities	ENG
20810023 - BIOMATERIALS (objectives) The course aims to provide students with the tools necessary to approach the study of elementary chemical processes and materials covered in this course, as well from a theoretical as from a practical point of view.
20810023-1 - BIOMATERIALS (MODULE 1) (objectives) The course aims to provide students with the tools necessary to approach the study of elementary chemical processes and materials covered in this course, as well from a theoretical as from a practical point of view. - ORSINI MONICA (syllabus) Biomaterials (I module) A.A. 2016/2017 1. Introduction History of biomaterials. Definition of biomaterials. Biocompatibility. Sterilization, prevention of infection. Classification of Biomaterials 2. Material properties Mechanical properties: Young's modulus; Stress–strain curves of different types of materials. Dynamic fatigue failure. Viscoelasticity. Hardness. Thermal Properties. 3. Organic Chemistry The Origins of Organic Chemistry. Principles of Atomic Structure. Bond Formation: The Octet Rule. Ionic and covalent Bonding. Electronegativity and Bond Polarity. Lewis Structures. Multiple Bonding. Resonance. Pi Bonding. Hybridization and geometry. Bond rotation. Structure and properties of Hydrocarbons: alkanes, alkenes, alkynes and aromatic hydrocarbons. Intermolecular Forces. Functional groups. Structure and properties of organic compounds: Halogenated compounds; Alcohols; Thiols; Ethers; Amines; Aldehydes; Ketones; Carboxylic acids. Brønsted–Lowry Acids and Bases. Condensation reaction of Acids with Alcohols: Esters. Condensation reaction of carboxylic acid and ammonia or an amine: Amides. Stereochemistry. 4. Polymers Definition. Classification of polymers. Characteristics and properties of polymeric materials: Degree of Polymerization; Molecular Weight; Degree of Polydispersity; Reticulation degree; Glass transition temperature; Melting temperature. Condensation polymers: Polyamides; Polyesters; Polyurethanes. Disadvantages of condensation polymers. Addition Polymers: Polyvinyl Chloride (PVC); polymethacrylate (PMA); Polymethyl methacrylate (PMMA); Hydrogels; Teflon (TFPE). Stereochemistry of polymers. The physical state of the polymers: Crystalline Polymers, Semi-Crystalline Polymers, Amorphous Polymers. Fibers. Elastomers: Natural Rubber, Synthetic rubbers, Silicones. Behavior of polymers as a function of temperature: thermoplastic polymers, thermosetting polymers. Thermoplastic polymers with high resistance: Polyacetals, Polysulfones, Polycarbonates. Biodegradable polymers. 5. Metallic biomaterials Structure, Properties and Applications. Types and Composition of Stainless Steels. Cobalt-based alloys: CoCrMo and CoNiCrMo alloy. Ti and Ti-based alloys (Ti6Al4V). Shape–memory alloys: Ni–Ti alloy. Corrosion of metallic implants. 6. Ceramic biomaterials Physical Properties. Sintering. Use of ceramic materials. Bioinert ceramics: alumina, zirconia and pyrolytic carbon. Bioactive ceramics: hydroxyapatite (HA), bioglasses or glass-ceramics. bioresorbable ceramics: tricalcium phosphate (TCP). 7. Hip prostheses Characteristics of hip prostheses and biomaterials used. Cementless and Cemented hip prostheses. Stress-shielding. Bone cement. 8. Heart Valve Implants The Functions of the Heart and natural Heart valves. Valvular heart disease. Mechanical valves: Caged ball valve, Monoleaflet mechanical valve, Bileaflet mechanical valve. Bioprosthetic valves: Porcine bioprosthetic valves, Pericardial bioprosthetic valves, Stentless Bioprostheses, Percutaneous Bioprostheses. Selecting the Optimal Prosthesis in the Individual Patient. 9. Vascular Prostheses Arterial disease: stenosis and aneurysm. Ideal characteristics of a graft. Implants of biological origin and implants of synthetic origin. Materials used in synthetic Implants. Porosity/permeability and Compliance of synthetic vascular prostheses. 10. Ophthalmic implants Contact lenses and intraocular lenses. General Properties of Materials of Relevance to Contact Lenses. Hard contact lenses. Soft contact lenses. Biomimetic lenses. Materials used for intraocular lenses. 11. Tissue response to implants Cellular Response to Implants: Ceramics, metals and polymers. Systemic Effects by Implants. Blood Compatibility. (reference books) "Biomaterials An introducion” Joon Park and R.S. Lakes Third Edition (Springer) “Biomaterials” Véronique Migonney (Wiley)	6	CHIM/07	48	-	-	-	Related or supplementary learning activities	ENG
20810023-2 - BIOMATERIALS (MODULE 2) (objectives) The course aims to provide students with the tools necessary to approach the study of elementary chemical processes and materials covered in this course, as well from a theoretical as from a practical point of view. - ORSINI MONICA (syllabus) Biomaterials (II module) A.A. 2016/2017 1. Surface modification of biomaterials Covalent coatings: Plasma treatment, Chemical vapor deposition (CVD), Physical vapor deposition (PVD), Radiation grafting/photografting, Self-assembled monolayer (SAM), Chemical grafting, Biological modification (biomolecule immobilization). Noncovalent coatings: Solution coatings, Langmuir-Blodgett films, Surface-modifying additives. Surface modification methods with no overcoat: Ion bean implantation, Plasma treatment, Conversion coatings. Patterning. 2. FT-IR Spectroscopy Working Principle of IR Spectroscopy. Instrumentation. FT-IR Techniques: Transmission, Internal Reflection Spectroscopy -Attenuated Total Reflection (ATR), External Reflection Spectroscopy- Specular Reflection. Interpretation of IR Spectra. 3. Electron Microscopy: SEM and TEM Introduction to Microscopy. Resolution. Electron-Matter Interactions. Working Principle of Scanning Electron Microscope SEM and characteristics. Working Principle of Transmission Electron Microscopy TEM and characteristics. 4. XPS X-Ray Photoelectron Spectroscopy Working Principle of XPS X-Ray Photoelectron Spectroscopy and applications. 5. Tissue engineering Basic principles and applications of Tissue engineering. (reference books) "Biomaterials An introducion” Joon Park and R.S. Lakes Third Edition (Springer) “Biomaterials” Véronique Migonney (Wiley)	3	CHIM/07	24	-	-	-	Related or supplementary learning activities	ENG

Second semester

Course	Credits	Scientific Disciplinary Sector Code	Contact Hours	Exercise Hours	Laboratory Hours	Personal Study Hours	Type of Activity	Language
20810022 - FUNDAMENTALS OF BIOMEDICAL ENGINEERING (objectives) The aim is the development o f the specific competencies for the study of the biological systems from the bioengineering point of view. The presented approach deals with the chain biological system-model-measurement and is devoted to specific applications such as the diagnosis, the therapy, the rehabilitation, the ergonomics and the sport medicine. The aim is the acquisition of the competencies for the use of the biomedical instrumentation contained in a human movement laboratory. The students will be exposed to the main hardware and software tools needed to i) design measurement chains, ii) define the population under exam, iii) extract the information from the recorded data.
20810022-2 - FUNDAMENTALS OF BIOMEDICAL ENGINEERING (MODULE 2) (objectives) The aim is the development o f the specific competencies for the study of the biological systems from the bioengineering point of view. The presented approach deals with the chain biological system-model-measurement and is devoted to specific applications such as the diagnosis, the therapy, the rehabilitation, the ergonomics and the sport medicine. The aim is the acquisition of the competencies for the use of the biomedical instrumentation contained in a human movement laboratory. The students will be exposed to the main hardware and software tools needed to i) design measurement chains, ii) define the population under exam, iii) extract the information from the recorded data. - BIBBO DANIELE (syllabus) The course aims to prepare students to the activities of a typical laboratory experimental research, on both design and practical aspects, in which the typical methods of biomedical engineering are applied, with particular reference to the arguments presented in the first module of the course. During teaching hours, the applicative concepts necessary to carry out laboratory work will be provided, with particular reference to the following topics: • The electronics equipment of an experimental laboratory. • Systems and sensor for the acquisitions and measure of biomedical data and signals: sensors for human movement analysis and for electrophysiological signals, signal conditioning and acquisition systems. • Experimental protocols for the acquisition of data: from the sensor to the digitization and storage on a computer. • The organization of the acquisition phase of biomedical data and signals. • The virtual instrumentation for the management of the experimental data: fundamentals of Labview. • The data collection, the biomedical signal elaboration and the statistical analysis. (reference books) • BRONZINO - BIOMEDICAL ENGINEERING HANDBOOK, TAYLOR AND FRANCIS GROUP • ONLINE TUTORIALS ON moodle2 web platform	6	ING-INF/06	48	-	-	-	Core compulsory activities	ENG
20810012 - BIOMEDICAL DATA PROCESSING (objectives) The aim is the acquisition of the competencies for the processing and the classification of the biomedical signals. The students will be trained to understand the connections among the different techniques of signal processing. Special attention will be devoted to the extension of the signal processing competencies to the biomedical field. - CONFORTO SILVIA (syllabus) Introduction to the course. Biomedical signals: Electroencephalography (EEG), Electromyography (EMG), Electrocardiography (ECG). Basic Elements of Signal Processing: representation in the Fourier domain, filtering, artifacts and noise rejection. Spectral estimation: non-parametric and parametric techniques. Time-frequency analysis: Short Time Fourier Transform and Spectrogram, Wavelet and Scalogram. Matlab Labs. (reference books) L. Sornmo, P. Laguna. Bioelectrical signal processing in cardiac and neurological applications. Elsevier Academic Press. 2005. Materials on-line (notes, exercises, solutions. Download from Moodle).	9	ING-INF/06	72	-	-	-	Core compulsory activities	ENG
20810013 - NEURAL ENGINEERING (objectives) To gain specific knowledge in theories, methods and technologies for understanding and analysing the functionality of the human nervous system. In particular, the course gives practical examples of applications in the field of assistive technologies in disability, like brain computer interfaces and neuroprosthetics. - DE MARCHIS CRISTIANO (syllabus) NEURAL ENGINEERING AA 2016-2017 BASICS OF NEURAL ENGINEERING - INTRODUCTION TO NEURAL ENGINEERING, DEFINITIONS, FIELDS OF APPLICATION, PAST AND PRESENT TECHNOLOGIES. - FOCUS OF THE COURSE: RECORDING FROM THE NERVOUS SYSTEM, STIMULATING THE NERVOUS SYSTEM, EXTRACTING FEATURES, DEFINING MODELS ----------------------------------------------------------------------------------------------------------------------------------------- PART 1 - FROM ANATOMY TO FUNCTION: NEURON MODELS - BASICS OF ANATOMY OF THE NERVOUS SYSTEM, BASICS OF ACTIVITY OF THE NERVOUS SYSTEM, NEURAL CELL STRUCTURE, NEURAL CELL FUNCTIONING, RESTING POTENTIAL, ACTION POTENTIAL GENERATION AND PROPAGATION - PASSIVE NEURON MODELS - ACTIVE NEURON MODELS: IF, H-H, FH-N ----------------------------------------------------------------------------------------------------------------------------------------- PART 2 - INTERFACING AND RECORDING DATA FROM THE NERVOUS SYSTEM - OBTAINING INFORMATION FROM THE NERVOUS SYSTEM: BIOELECTRODES, TECHNOLOGICAL SOLUTIONS FOR TRANSFORMING ION CURRENTS INTO ELECTRONIC CURRENTS - NEURAL RECORDING: MICROELECTRODES - BIOPOTENTIALS: BASICS OF ELECTROMYOGRAPHY - BIOPOTENTIALS: BASICS OF ELECTROENCEPHALOGRAPHY ----------------------------------------------------------------------------------------------------------------------------------------- PART 3 – EXTRACTING INFORMATION FROM THE NERVOUS SYSTEM - SPIKE DETECTION - SPIKE SORTING - ACTIVITY 1: SPIKE DETECTION AND SORTING FROM NEURAL SIGNALS - ACTIVITY 2: NEURAL SYSTEM - MODEL IDENTIFICATION - Muscle Synergies ----------------------------------------------------------------------------------------------------------------------------------------- PART 4: STIMULATING THE NERVOUS SYSTEM - STIMULATING THE NERVOUS SYSTEM: DIFFERENT SOLUTIONS FOR ARTIFICALLY ACTIVATING THE NEURAL CELLS – BASICS OF TMS, TACS, TDCS, DBS, NMES. - NMES-FES. TECHNOLOGICAL ASPECTS, NEUROPHYSIOLOGICAL PRINCIPLES, APPLICATIONS. - ACTIVITY 3: EMG ANALYSIS IN RESPONSE TO ELECTRICAL STIMULATION. M wave and H reflex ----------------------------------------------------------------------------------------------------------------------------------------- (reference books) Horch, K. W., & Dhillon, G. S. (Eds.). (2004). Neuroprosthetics: theory and practice (Vol. 2). World Scientific. He, B. (Ed.). (2007). Neural engineering. Springer Science & Business Media.	6	ING-INF/06	48	-	-	-	Core compulsory activities	ENG
20810014 - ADVANCES IN BIOMEDICAL ENGINEERING (objectives) To acquire in-depth skills on a selection of relevant topics in the field of practice and research in bioengineering. To be able to design and conduct experimental and methodological activities in the areas of application and research in the biomedical sector. - Penhaker Marek (syllabus) Problem-based learning to introduce students to the recent advances in biomedical engineering, with a specific emphasis on the design of biomedical devices and systems in the diagnostic area. Students are exposed to the theory associated with the acquisition and recording of biomedical signals through dedicated circuits; use of multimeters, oscilloscopes, spectrum analyzers; sensing and transduction; filtering, conditioning, and amplification stages; A/D conversion, digitalization; post-recording processing. Lab activities in small groups to use virtual design and computational tools to design, propose and validate feasible solutions to real-world biomedical engineering problems of clinical and diagnostic relevance. The introduction covers the principles of formation, recording and basic processing of biological signals. The remaining sections describe diagnostic devices and methods of measurement used by them. (reference books) Handouts and textbooks made available on the moodle platform "Medical Electronic devices” by Marek Penhaker and Martin Imramovsky, available online on the moodle platform	6	ING-INF/06	48	-	-	-	Core compulsory activities	ENG

SECOND YEAR

First semester

Course	Credits	Scientific Disciplinary Sector Code	Contact Hours	Exercise Hours	Laboratory Hours	Personal Study Hours	Type of Activity	Language
20810015 - BIOMECHANICS (objectives) Knowing how to identify the biomechanical model of the human body and be able to determine the most appropriate geometric and inertial parameters. Know the conceptual and mathematical tools useful for representing human motion in virtual reality and to describe joint kinematics. Being able to estimate the joint moments and forces acting on the hard and soft passive tissues transmitted by the muscles during movement. Being able to describe a motor act using the language of the mechanical work and energy. Know basic mechanical properties of soft and hard biological tissues. Understanding the biomechanics of human joints and spine. Know the biomechanics of physical activities of daily living such as walking, climb and descent of stairs, getting up and sitting etc.. Know the basic biomechanical principles to describe and evaluate sports paradigmatic gestures (jumping, throwing, hitting). Being familiar with the tools that allow the measurement of human movement and external forces. Be familiar with the laboratory of movement analysis and experimental protocols. Knowing how to assess risks for the locomotor apparatus in sport and at work. Acquiring the ability to design an experimental procedure, based on the use of these instruments and protocols, for clinical purposes or with reference to sport and ergonomics. Web site http://elearning.dismus.it/ - CAMOMILLA VALENTINA (syllabus) Knowing how to identify the biomechanical model of the human body and be able to determine the most appropriate geometric and inertial parameters. Know the conceptual and mathematical tools useful for representing human motion in virtual reality and to describe joint kinematics. Being able to estimate the joint moments and forces acting on the hard and soft passive tissues transmitted by the muscles during movement. Being able to describe a motor act using the language of the mechanical work and energy. Understanding the biomechanics of human joints and spine. Know the biomechanics of physical activities of daily living such as walking, climb and descent of stairs, getting up and sitting etc.. Know the basic biomechanical principles to describe and evaluate sports paradigmatic gestures (jumping, throwing, hitting). Being familiar with the tools that allow the measurement of human movement and external forces. Be familiar with the laboratory of movement analysis and experimental protocols. Knowing how to assess risks for the locomotor apparatus in sport and at work. Acquiring the ability to design an experimental procedure, based on the use of these instruments and protocols, for clinical purposes or with reference to sport and ergonomics. (reference books) Materiale fornito dal docente; Kinematics of Human Motion e Kinetics of Human Motion di Vladimir M. Zatziorsky, 1998, Human Kinetics, Champaign, Illinois, USA.; Kinematic Analysis of Human Movement, Cheze Laurence, John Wiley & Sons 2014; Gait Analysis: Normal and Pathological Function Perry Jacquelin and Burnfield Judith, SLACK; 2010; An introduction to biomechanics of sport and exercise James Watkins, Churchill Livingstone, 2007.	9	ING-INF/06	72	-	-	-	Core compulsory activities	ENG
20810016 - CLINICAL ENGINEERING (objectives) The present subject deals with methods for safety and performance quality evaluation of devices for therapy and diagnosis. Moreover, the organization and management of a clinical engineering service will be examined in the perspective of the maintenance of biomedical devices, within the italian health system. - SCIUTO SALVATORE ANDREA (syllabus) INTRODUCTION TO THE COURSE. REVIEW OF METROLOGY. MAIN PHYSICAL QUANTITIES IN BIOMEDICAL EQUIPMENT AND MEASUREMENT SYSTEMS. AN OVERVIEW OF MEASUREMENTS FOR DIAGNOSTICS. FUNDAMENTALS OF CELL BIOLOGY. CHARACTERISATION AND TESTING OF MEDICAL INSTRUMENTS FOR DIAGNOSIS AND THERAPY. EQUIPMENT FOR OPERATING ROOM AND INTENSIVE CARE. PRINCIPLES AND TECHNIQUES OF BLOOD PRESSURE MEASUREMENT. MEDICAL INFUSION PUMPS. MEASUREMENTS FOR MECHANICAL VENTILATION CHARACTERIZATION AND TESTING. RESPIRATORY MECHANICS AND DIAGNOSTIC INSTRUMENTS. BASICS OF ANESTHESIA DELIVERY SYSTEMS. PULMONARY VENTILATORS. ULTRASONIC AND ELECTROSURGICAL DEVICES. SYSTEMS FOR EXTRACORPOREAL CIRCULATION. AN OVERVIEW ON DIAGNOSTIC IMAGING SYSTEMS IN HOSPITALS AND QUALITY ASSURANCE PROGRAMS. AN OVERVIEW ON SYSTEMS AND INSTALLATIONS IN HOSPITALS. TEST METHODS FOR BIOMEDICAL EQUIPMENT AND INSTALLATIONS, AUDITS FOR QUALITY ASSURANCE. MANAGEMENT AND MAINTENANCE CRITERIA OF THE MEDICAL EQUIPMENT. GENERAL CRITERIA FOR THE ORGANIZATION OF A CLINICAL ENGINEERING DEPARTMENT. (reference books) • NOTES AND PRESENTATIONS FROM THE COURSE. • FRANCESCO PAOLO BRANCA “FONDAMENTI DI INGEGNERIA CLINICA - VOL. 1”, SPRINGER-VERLAG ITALIA 2000. • FRANCESCO PAOLO BRANCA “FONDAMENTI DI INGEGNERIA CLINICA - VOL. 2”, SPRINGER-VERLAG ITALIA 2008. • J.G. WEBSTER “MEDICAL INSTRUMENTATION:APPLICATION AND DESIGN”, ED. WILEY AND SONS. • RINALDO VALLASCAS “FONDAMENTI DI MISURE MECCANICHE E TERMICHE. GRANDEZZE STATICHE E SISTEMI” HOEPLI 2008. • RINALDO VALLASCAS, FEDERICO PATANE' “MISURE MECCANICHE E TERMICHE” - GRANDEZZE TEMPO-VARIANTI, HOEPLI 2007. • PAOLO CAPPA “SENSORI E TRASDUTTORI PER MISURE MECCANICHE E TERMICHE” BORGIA EDITORE.	9	ING-IND/12	72	-	-	-	Related or supplementary learning activities	ENG
20810017 - MEDICAL DEVICES AND SYSTEMS (objectives) The course aims at: • presenting a comprehensive framework of the technologies commonly used in healtcare, with specific reference to imaging systems, used for diagnostic purposes and for treatment, and • giving the fundamentals for the management of data for the diagnosis and for the assessment of treatments. - SCHMID MAURIZIO (syllabus) Medical dvices and systems: common operating principles and specs Diagnostic medical devices - Medical imaging X-Ray Imaging: operating principles and theory (x-ray production, x-ray detection); equipment, specs, technical considerations; patient dose; quality parameters; angiography CT Imaging: operating principles and theory; image reconstruction; instrumentation, specs, technical considerations; quality parameters; contrast agents; current technology trends US Imaging: operating principles and theory, instrumentation, procedures, specs, technical considerations; Doppler US MR Imaging: MR theoryu and operating principles; image reconstruction; instruments, specs, technical considerations; pulse sequences; functional MRI (fMRI); current technology trends Therapeutics medical devices - Minimally invasive surgery Systems for angioplasty (balloon, stent): operating principles; procedures; equipment, specs, technical considerations Therapeutics medical devices - Open surgery procedures and Functional substitution Heart valve replacement: artificial heart valves, biological heart valves; operating principles; procedures; instrumentation; specifications. (reference books) - Slides, handouts, exercises, available online on Roma Tre Moodle platform. - Readings from: Medical devices and human engineering (Biomedical Engineering Handbook - Volume III) Biomedical Signals, Imaging, and Informatics (Biomedical Engineering Handbook - Volume IV)	9	ING-INF/06	72	-	-	-	Core compulsory activities	ENG
20810018 - BIOELECTROMAGNETICS (objectives) To learn the foundations of bioelectromagnetics finalized to the analysis of the electromagnetic interactions among the biological systems and the electromagnetic field. To model absorption and scattering phenomena in living systems in order to protect the natural environment against the elecromagnetic pollution. - TOSCANO ALESSANDRO (syllabus) Evaluation of the electromagnetic field induced in biological tissues. Electromagnetic properties of biological tissues. Electromagnetic dosimetry. European safety standards. (reference books) Normativa CEI 211-6 e 211-7	9	ING-INF/02	72	-	-	-	Related or supplementary learning activities	ENG

Second semester

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Optional group: AD A SCELTA - (show)

20810019 - BIOPHOTONICS (objectives) The Course provides the fundamentals of biophotonics, and biophotonic systems, devices and instruments. Their design, fabrication and applications are considered, evidencing the cutting-edge between biology and photonics. The course content covers: electronic and Raman spectroscopy, lasers and their applications in medicine, imaging systems for bio-medical diagnostics, confocal and multiphoton microscopy, nanoscopy for cell imaging, molecular imaging based on optical methods, optical coherence tomography and flow-cytometry. - CINCOTTI GABRIELLA (syllabus) • Fundamentals of light and matter Light propagation in vacuum and through dielectric media, interference, diffraction, coherence. Polarization of light, optical activity and birefringence. Light sources and photons. Schrödinger equation in the box and in the Hydrogen atom. Quantized states in atoms and molecules. Electronic and vibrational states of a molecule. Stereoisomers. • Basics of biology Cellular structure and types; chemical building blocks; cellular processes: replication, biosynthesis and energy production; protein classification and function; organization of cells into tissues. • Light-matter interactions Interactions between light and a molecule; Einstein’s model of absorption and emission; interaction of light with a bulk matter; fate of excited states; electronic absorption spectroscopy; electronic luminescence spectroscopy; Raman spectroscopy; spectroscopy utilizing optical activity of chiral media; fluorescence correlation spectroscopy. • Lasers principles of lasers, classifications; biophotonic applications; radiometry; nonlinear optics; multiphoton absorption; time-resolved approaches; laser safety. • Bioimaging Overview of optical imaging; transmission microscopy; simple and compound microscope; numerical aperture and resolution; phase contrast microscopy; fluorescence microscopy; scanning microscopy; confocal microscopy; optical coherence tomography; spectral and time-resolved imaging; localized spectroscopy; fluorescence resonance energy transfer (FRET) imaging; fluorescence lifetime imaging microscopy (FLIM); coherent anti-stokes raman scattering (CARS). • Flow cytometry Components of a flow cytometer; optical response; fluorochromes for flow cytometry; data manipulation and presentation; immunophenotyping; DNA analysis. (reference books) P. N. Prasad - Introduction to Biophotonics	9	ING-INF/06	72	-	-	-	Elective activities	ENG
20810020 - ADVANCED CHARACTERIZATION OF BIOMATERIALS (objectives) The objective is to expose students of the Laurea Magistrale to an application/experimental-driven experience. This objective is achieved by means of a series of dedicated lectures and experimental activities performed in the Multifunctional Materials Laboratory. These activities are focused on the theoretical and experimental study of some manufacturing processes and characterization techniques of advanced biomaterials. - LANZARA GIULIA (syllabus) Key concepts of mechanics of materials are first presented. These concepts are then used to discuss the behavior of natural and artificial biological materials and their applications. Synthesis, production and characterization of advanced active and passive materials - including intelligent materials - are discussed. A wide variety of characterization techniques will be presented starting from a morphological assessment up to the functional response. The characterization, synthesis/production techniques will be presented with a theoretical and an experimental approach through dedicated laboratory activities. The experimental activities are dedicated to specific techniques for the synthesis of artificial biomaterials as well as to produce and characterize new materials. An important part of the course is dedicated to the implementation of an experimental or numerical short thesis that will target specific applications in the biomedical field. (reference books) Lectures will be distributed during the course	9	ING-IND/22	72	-	-	-	Elective activities	ENG

20802015 - TRAINING

Per stages e tirocini presso imprese, enti pubblici o privati, ordini professionali (art.10, comma 5, lettera e)

ENG

20802113 - ART. 10, COMMA 5, LETTERA D

Other activities

ENG

20802091 - FINAL EXAM

300

Final examination and foreign language test

ENG