Optional group:
AFFINI E INTEGR - (show)
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20401076 -
MICROBIAL BIOTECHNOLOGY
(objectives)
THE MAIN AIMS OF THE COURSE ARE:
A) DEVELOPMENT OF THE CAPABILITY TO ANALYZE INTERCONNECTED METABOLIC PROCESSES
B) ACQUISITION OF COMPETENCE IN USING EXPERIMENTAL METHODOLOGIES AND STRATEGIES FOR OBTAINING INDUSTRIAL MICRORGANISMS WITH SPECIFIC CHARACTERISTICS.
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20401081 -
ETHOLOGY AND ANIMAL BEHAVIOUR
(objectives)
PROVIDING STUDENTS WITH CONCEPTUAL BASIS FOR: (a) UNDERSTANDING BIOLOGICAL BASIS OF BEHAVIOR (b) UNDERSTANDING BEHAVIOR AS AN EMERGENT PROPERTY OF THE SYSTEM “ORGANISM” (c) AN EVOLUTIONARY APPROACH TO THE STUDY OF BEHAVIOR. PROMPTING STUDENTS’ CRITICAL THINKING BY MEANS OF APPROPRIATE READINGS AND DISCUSSIONS. THEREFORE STUDENTS WILL BE GIVEN TOOLS TO CORRECTLY EVALUATE A SCIENTIFIC HYPOTHESIS, CHOOSE APPROPRIATE TOOLS OF INVESTIGATION AND INTERPRET RESULTS.
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Derived from
20401081 ETOLOGIA in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 N0 CAROSI MONICA
( syllabus)
Cultural skills (Knowledge of:) The course offers the conceptual bases for (A) understanding the biological bases of behaviour (B) understanding behaviour as an emergent property of the organism (C) an evolutionary approach to the study of behaviour .
Methodological skills (Knowing how to perform:) acquire the critical thinking through readings and discussions, in order to correctly evaluate a research hypothesis, choose research tools and interpret results.
SYLLABUS
Ethology: historical outline. Classic and operant conditioning. The three Nobel awards, founders of modern ethology: K. Lorenz, K. Von Frisch, and N. Tinbergen. Sociobiology and behavioral ecology. The evolutionary approach to the study of behaviour. Levels of analysis in the study of behaviour: questions on “how” and “why”. The study of causation and ontogenesis (proximate causes), survival value and evolution (ultimate causes).
(1) Behavioural control. Exogenous factors and endogenous factors. Sensory filtering. Stimuli and signals. Fixed action patterns, evocative stimuli, innate triggering mechanism. Biorhythms. The biological clock. The hormonal state. The behavioural decision: the motivation. Spatial orientation. Compasses. The olfactory map.
(2) Ontogenesis of behaviour. Role of genes and the environment. Embryology and behaviour: pre-natal ontogeny. Embryonic development of motility, sensitivity and sensory-motor sequences. Neurogenesis. Embryo learning. Postnatal ontogenesis. Behavioural endocrinology. The interactive theory of development, the organisational-activational hypothesis: development organisation, sexualisation of the brain, neural activation. Pre and post-natal learning. Imprinting and hormonal control of imprinting. Non-associative, associative, and complex learning. Behavioural control: nervous system and hormonal system.
(3) The adaptive value of behaviour. The comparative approach to the study of behaviour. Signal evolution and communication. Communication: definitions, honest communication and deception. Ritualisation. Natural and artificial selection. Hybridisation between lines. Behavioural characters and strategies. Optimal strategies and evolutionarily stable strategies. Predatory and anti-predatory strategies: the arms race. Mimicry. Reproductive and social behaviour. Optimal strategies, fitness and reproductive success. Sexuality and innovation. Sexual selection: partner choice and competition. Sexual selection and sexual dimorphism. Conflict strategies between sexes. Differential reproductive success of females and males. Parental investment. Mating systems and social life. Sociality and group life: costs and benefits of socializing; the kin selection; altruism and evolution. Game theory.
( reference books)
RECOMMENDED TEXTBOOKS:
- Alcock, J. 2007. Etologia, un approccio evolutivo. Zanichelli
- Manning, A. e Stamp Dawkins, M. 2003. Il comportamento animale. Bollati Boringhieri.
- Krebs J.R. e Davies N.B. 2002. Ecologia e comportamento animale. Bollati Boringhieri
TEXTBOOKS FOR FURTHER READINGS:
- Bolhuis, J.J. & Giraldeau, l. 2005. The behavior of animals: mechanisms, function and evolution.
- Campan, R. & Scapini, F. 2004. Etologia. Zanichelli
- Nelson, N.J. 2002. An introduction to behavioral endocrinology. Sinauer Associates, Sunderland
- Andersson, M 1994. Sexual selection. Princeton University Press
- Mainardi, D. 1992. Dizionario di etologia. Einaudi
- Martin, P. & Bateson, P. 2003. La misurazione del comportamento. Una guida introduttiva. Liguori editore
All textbooks can be found in the library
Students are provided with a document that lists for each lesson topic which textbook and which chapters are most relevant for the study, and for each topic it lists recent scientific papers for further study. Students are also provided with PDFs of lessons and of scientific papers suggested.
The professor receives every day from 9.00 to 10.00 by appointment via email: monica.carosi@uniroma3.it
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20401221 -
MOLECULAR GENETIC AND CYTOGENETIC TECHNIQUES
(objectives)
PROVIDE THE STUDENT KNOWLEDGE THEORY AND PRACTICES THAT MAKE COMPETENT AND CAPABLE OF APPLIED TECHNOLOGIES OF CLASSIC CYTOGENETICS (VARIOUS TYPES OF BANDING) THAT MOST OF MODERN TECHNOLOGY (FISH, CGH) IN HIGHER ORGANISMS EUKARYOTES.
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20401221-2 -
MODULO 2
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TANZARELLA CATERINA
( syllabus)
THE COURSE IN TWO PARTS, A THEORY AND PRACTICE (IN ITALICS AND BOLD) STRONGLY ASSOCIATED WITH EACH OTHER.- THE FIRST STUDY ON CHROMOSOME, HAPLOID, DIPLOID, CELL CYCLE, MITOSIS, MEIOSIS AND THE BEGINNING OF CYTOGENETICS- STRUCTURAL ELEMENTS OF CHROMOSOME EUKARYOTIC DNA ORGANIZATION IN CHROMOSOMES, CHROMOSOME SCAFFOLD AND NUCLEAR MATRIX, EUCHROMATIN AND HETEROCHROMATIN. X-CHROMOSOME INACTIVATION COMPLEXITY 'GENOME EUKARYIOTIC- USE OF DATABASES AS A SUPPORT TO TRIAL IN GENETICS- SETTING UP PREPARATIONS METAPHASE- THE CENTROMERE, THE CENTROMERIC DNA FROM YEAST MAN, HUMAN SATELLITE DNA, CENTROMERE PROTEINS CONSTITUENT. CENTROMERE PROTEINS OPTIONAL- IMMUNOLOGICAL AND MOLECULAR TECHNIQUES TO HIGHLIGHT THE CENTROMERIC REGIONS- TELOMERE STRUCTURE: TELOMERIC SEQUENCE AND THE ROLE OF TELOMERIC PROTEIN, FUNCTION: MITOTIC CLOCK AND MAINTAINING THE STABILITY 'GENOMICS.- MOLECULAR TECHNIQUES TO HIGHLIGHT THE TELOMERES- FORENSIC GENETICS AND DETERMINATION OF PATERNITY '- STRUCTURAL CHROMOSOME ABERRATIONS AND NUMERICAL ORIGINATE 'de novo' (LEUKEMIA) OR TRANSMITTED BY HEREDITARY (GENETIC SYNDROMES)- BANDING TECHNIQUES MODERN AND TECHNIQUES TO PUT IN EVIDENCE AND CHROMOSOMES KARYOTYPES- TECHNIQUES IN MOLECULAR GENETIC DIAGNOSIS OF LEUKEMIA* TWO EXERCISES MAY BE CARRIED OUT AT THE HOSPITAL STRUCTURE OF GENERAL HOSPITAL OF TOR VERGATA
( reference books)
T.D.POLLARD, W.C.EARNSHAW: CELL BIOLOGY, SAUNDERS, 2002 CAPITOLO 12: CHROMOSOME ORGANIZATION CHAPTER 13: DNA PACKAGING IN CHROMATIN AND CHROMOSOMES SUMNER A.T.: CHROMOSOMES: ORGANIZATION AND FUNCTION, BLACKWELL, 2003 CHAPTER 7: CONSTITUTIVE HETEROCHROMATIN TURNER B. M. CHROMATIN AND GENE REGULATION, BLACKWELL SCIENCE, 2001 CHAPTER 12: MECHANISMS OF DOSAGE COMPENSATION, P. 249-261. CLEVELAND D.W., MAO, SULLIVAN: CENTROMERE AND KINETOCHORES: FROM EPIGENETICS TO MITOTIC CHECKPOINT SIGNALING, CELL, 112, 407- 421. (2003)WATRIN E. AND LEGAGNEUX V. INTRODUCTION TO CHROMOSOME DYNAMICS AT MITOSIS. BIOLOGY OF THE CELL 95 507-513 (2003)
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20401221-1 -
MODULO 1
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TANZARELLA CATERINA
( syllabus)
THE COURSE IN TWO PARTS, A THEORY AND PRACTICE (IN ITALICS AND BOLD) STRONGLY ASSOCIATED WITH EACH OTHER.- THE FIRST STUDY ON CHROMOSOME, HAPLOID, DIPLOID, CELL CYCLE, MITOSIS, MEIOSIS AND THE BEGINNING OF CYTOGENETICS- STRUCTURAL ELEMENTS OF CHROMOSOME EUKARYOTIC DNA ORGANIZATION IN CHROMOSOMES, CHROMOSOME SCAFFOLD AND NUCLEAR MATRIX, EUCHROMATIN AND HETEROCHROMATIN. X-CHROMOSOME INACTIVATION COMPLEXITY 'GENOME EUKARYIOTIC- USE OF DATABASES AS A SUPPORT TO TRIAL IN GENETICS- SETTING UP PREPARATIONS METAPHASE- THE CENTROMERE, THE CENTROMERIC DNA FROM YEAST MAN, HUMAN SATELLITE DNA, CENTROMERE PROTEINS CONSTITUENT. CENTROMERE PROTEINS OPTIONAL- IMMUNOLOGICAL AND MOLECULAR TECHNIQUES TO HIGHLIGHT THE CENTROMERIC REGIONS- TELOMERE STRUCTURE: TELOMERIC SEQUENCE AND THE ROLE OF TELOMERIC PROTEIN, FUNCTION: MITOTIC CLOCK AND MAINTAINING THE STABILITY 'GENOMICS.- MOLECULAR TECHNIQUES TO HIGHLIGHT THE TELOMERES- FORENSIC GENETICS AND DETERMINATION OF PATERNITY '- STRUCTURAL CHROMOSOME ABERRATIONS AND NUMERICAL ORIGINATE 'de novo' (LEUKEMIA) OR TRANSMITTED BY HEREDITARY (GENETIC SYNDROMES)- BANDING TECHNIQUES MODERN AND TECHNIQUES TO PUT IN EVIDENCE AND CHROMOSOMES KARYOTYPES- TECHNIQUES IN MOLECULAR GENETIC DIAGNOSIS OF LEUKEMIA* TWO EXERCISES MAY BE CARRIED OUT AT THE HOSPITAL STRUCTURE OF GENERAL HOSPITAL OF TOR VERGATA
( reference books)
T.D.POLLARD, W.C.EARNSHAW: CELL BIOLOGY, SAUNDERS, 2002 CAPITOLO 12: CHROMOSOME ORGANIZATION CHAPTER 13: DNA PACKAGING IN CHROMATIN AND CHROMOSOMES SUMNER A.T.: CHROMOSOMES: ORGANIZATION AND FUNCTION, BLACKWELL, 2003 CHAPTER 7: CONSTITUTIVE HETEROCHROMATIN TURNER B. M. CHROMATIN AND GENE REGULATION, BLACKWELL SCIENCE, 2001 CHAPTER 12: MECHANISMS OF DOSAGE COMPENSATION, P. 249-261. CLEVELAND D.W., MAO, SULLIVAN: CENTROMERE AND KINETOCHORES: FROM EPIGENETICS TO MITOTIC CHECKPOINT SIGNALING, CELL, 112, 407- 421. (2003)WATRIN E. AND LEGAGNEUX V. INTRODUCTION TO CHROMOSOME DYNAMICS AT MITOSIS. BIOLOGY OF THE CELL 95 507-513 (2003)
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20401283 -
HUMAN GENETICS
(objectives)
PROVIDE SKILLS TO STUDENTS ABOUT SOME THEORETICAL ASPECTS OF HUMAN GENETICS WITH PARTICULAR ATTENTION TO THE RELATIONSHIP GENE-DISEASE.
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20401283-2 -
MODULO 2
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SGURA ANTONELLA
( syllabus)
hands-on classes:cellula culture of human cells. Fixation and metaphase preparationFluorescent in situ hybridization (FISH) to label chromosome ends (telomeres) responsible of genomic stabilityIndirect immunofluorescence to label kinetochore proteins responsible of correct chromosome segregation and thus genomic stability
( reference books)
GENETICA UMANA, Ricky Lewis, PICCIN.Biologia molecolare della cellula, Bruce Alberts, Zanichelli.OFFICE HOURS AT THE END OF THE CLASS AND BY PRIOR APPOINTMENT
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20401283-1 -
MODULO 1
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SGURA ANTONELLA
( syllabus)
The principal aim of the course in human genetics has the objective to provide students with cytogenetic and modern human genetics knowledges. Modern human genetics is based on the new researches on the mechanisms involved in inherited genes, both for physiological and pathological processes.Chromatin structural organization. Chromatin epigenetic changes. Centromeres. Telomeres. Structural chromosome aberrations. Aneuploidy. Meiosis and development. Single-Gene Inheritance. Multifactorial Traits. Genetics of Behavior. Sex genetics.Gene Expression and Epigenetics. Gene Mutation. DNA repair syndromes. Uniparental disomy. Clinical genetics and cytogenetics. Costitutional chromosomal rearrangements .chromosomal rearrangements and mutations acquired. Genetic Technology.
( reference books)
GENETICA UMANA, Ricky Lewis, PICCIN.Biologia molecolare della cellula, Bruce Alberts, Zanichelli.OFFICE HOURS AT THE END OF THE CLASS AND BY PRIOR APPOINTMENT
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COZZI RENATA
( syllabus)
Chromatin structural organization. Chromatin epigenetic changes. Centromeres. Telomeres. Structural chromosome aberrations. Aneuploidy. Meiosis and development. Single-Gene Inheritance. Multifactorial Traits. Genetics of Behavior. Gene Expression and Epigenetics. Gene Mutation. DNA repair syndromes. Uniparental disomy. Clinical genetics and cytogenetics. Costitutional chromosomal rearrangements .chromosomal rearrangements and mutations acquired. Genetic Technology.
( reference books)
GENETICA UMANA, Ricky Lewis, PICCIN.
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20402361 -
BIOCHIMICA E BIOLOGIA MOLECOLARE APPLICATA
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20401653 -
BIOCHEMISTRY AND MOLECULAR CLINICAL BIOLOGY
(objectives)
Main goals of the course are: i) to provide an overview of the activities of a clinical laboratory looking at the organizational context and current business; ii) to illustrate the various stages which are at the basis of main analytical methods, either molecular or biochemical, used in biomedical laboratories for modern diagnostic purposes; iii) to provide the key of Interpretation for the obtained results from a pathophysiological point of view. To promote a critical approach towards laboratori diagnosis.
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BARONI SILVIA
( syllabus)
• LABORATORY MEDICINE AND CLINICAL BIOCHEMISTRY
BIOCHEMICAL TESTS AND LABORATORY MANAGEMENT
PREANALYTICAL, ANALYTICAL AND BIOLOGICAL VARIABILITY
REFERENCE VALUES
• QUALITY CONTROL ASSURANCE
• ANALYTICAL METHODS
IMMUNOCHEMISTRY AND INTERFERENCES
• LABORATORY ANDCARDIOVASCULAR DISEASES
LIPIDS AND MARKERS OF CARDIAC DAMAGE
• LABORATORY AND DIABETES MELLITUS
• LABORATORY AND RENAL FUNCTION
URINALYSIS
• ACID-BASE BALANCE
• LABORATORY AND NEUROLOGICAL DISEASES
CEREBROSPINAL FLUID
• LABORATORY AND ONCOLOGY
• LABORATORY AND THYROID
• LABORATORY AND MALE INFERTILITY
• INTRODUCING CLINICAL MOLECULAR BIOLOGY
( reference books)
GIORGIO FEDERICI ET AL. MEDICINA DI LABORATORIO. MC GRAW-HILL. MILANO, 2008
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20401656 -
BIOGEOGRAPHY
(objectives)
AFTER THE COURSE, THE STUDENTS SHOULD BE ABLE TO: 1) DISCUSS THE HISTORICAL AND ECOLOGICAL FACTORS THAT AFFECTED THE GEOGRAPHICAL DISTRIBUTION OF ANIMALS AND PLANTS; 2) FORMULATE HYPOTHESES AND MODELS EXPLAINING THE SHAPE, SIZE AND POSITION OF THE GEOGRAPHIC RANGE OF A TAXON; 3) DISCUSS EVENTS OF RANGE EXPANSION OR CONTRACTION, DUE TO CLIMATIC CHANGES OR HABITAT TRANSFORMATION CAUSED BY HUMAN ACTIVITIES; 4) DESCRIBE THE FAUNA, FLORA AND VEGETATION OF EACH CONTINENT, IN RELATION TO PAST AND PRESENT GEOGRAPHICAL AND ECOLOGICAL FACTORS; 5) BUILD PREDICTIVE MODELS FOR BIODIVERSITY CONSERVATION AND MANAGEMENT, IN CONNECTION WITH CLIMATE CHANGES AND LANDSCAPE ALTERATION.
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Derived from
20401656 BIOGEOGRAFIA in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 N0 CARPANETO GIUSEPPE
( syllabus)
GENERAL BIOGEOGRAPHY (3 CFU). SCHOOLS AND METHODS FOR STUDYING THE GEOGRAPHICAL DISTRIBUTION OF THE ORGANISMS. RELATIONS AMONG BIOGEOGRAPHY, ECOLOGY, SYSTEMATICS AND EARTH SCIENCES. PALEOGEOGRAPHY AND THE THEORY OF CONTINENTAL DRIFT; PLEISTOCENE CHANGES IN CLIMATE AND COASTLINE SHAPE (GLACIAL/INTERGLACIAL AND PLUVIAL/INTERPLUVIAL PERIODS, MARINE REGRESSIONS AND TRANSGRESSIONS) WITH THEIR EFFECTS ON ANIMAL AND PLANT DISTRIBUTION. THE GEOGRAPHIC RANGE (DISPERSAL, COLONIZATION, BARRIERS, EXTINCTION). ISLAND BIOGEOGRAPHY AND FRAGMENTATION BIOLOGY. ENDEMIC AND RELIC SPECIES. VICARIANCE AND DISPERSAL. SIGNIFICANCE AND BORDERS OF THE BIOGEOGRAPHIC REGIONS, TRANSITIONAL ZONES AND BIOMES.
ANALYSIS OF BIOGEOGRAPHICAL REGIONS AND TRANSITIONAL ZONES (3 CFU): OLOARCTIC REGION (PALEARCTIC AND NEARCTIC SUBREGIONS), AFROTROPICAL REGION, INDOMALAYAN REGION, AUSTRALIAN REGION. GEOGRAPHICAL AND ECOLOGICAL TRAITS OF EACH BIOGEOGRAPHICAL REGION AND BASIC KNOWLEDGE ON FAUNA, FLORA AND VEGETATION. EXAMPLES OF SPECIES AND TAXONOMIC GROUPS ENDEMIC TO DIFFERENT BIOMES FOR EACH REGION, WITH HYPOTHESES ON THEIR ORIGIN. STUDY CASES: MADAGASCAR AND NEW ZEALAND.
( reference books)
ZUNINO M & ZULLINI A, 2004. BIOGEOGRAFIA (SECONDA EDIZIONE). CASA EDITRICE AMBROSIANA, MILANO (MAIN TEXT) + DOCUMENTI ELETTRONICI DISTRIBUITI DAL DOCENTE.
FOR A DEEPER INSIGHT:
LOMOLINO MV ET AL., 2010. BIOGEOGRAPHY (FOURTH EDITION), SINAUER ASSOCIATES
MORRONE JJ, 2009. EVOLUTIONARY BIOGEOGRAPHY: AN INTEGRATIVE APPROACH WITH CASE STUDIES. COLUMBIA UNIVERSITY PRESS.
The professor receives every day from 15:00 to 18:30 by appointment via email: giuseppe.carpaneto@uniroma3.it
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20401660 -
ANALYTICAL CHEMISTRY
(objectives)
Promote to the student a deep knowledge of the main methodologies of analytical chemistry, by both traditional and advanced methods with specific attention to experimental methods using specific apparatus. The intention is to give to the students the basic and advanced conceptual means to understand the meaning of the different analytical methodologies in order to predict and evaluate the results. The knowledge of the chemical principles and laws will allow to enhance the formation by experimental check by means of classical and complex analytical methods, as for instance IR, UV-VIS, fluorescence and X-ray photoelectron spectroscopies, as well as gas chromatography and HPLC together with mass spectrometry.
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20401668 -
ENVIRONMENTAL MICROBIOLOGY
(objectives)
THE MAIN AIMS OF THE COURSE ARE:
1) RECOGNIZE MAJOR GROUPS OF MICROORGANISMS AND UNDERSTAND FACTORS INFLUENCING THEIR ENVIRONMENTAL DISTRIBUTION AND INTERACTIONS WITH HIGHER ORGANISMS;
2) LEARN ABOUT ROLES PLAYED BY MICROBES IN SOIL FORMATION, MINERAL WEATHERING, CARBON AND NITROGEN CYCLING;
3) LEARN ABOUT CULTURE-BASED AND CULTURE-INDEPENDENT MICROBIOLOGICAL METHODS;
4) GAIN LITERACY IN CRITICAL READING AND ANALYSIS OF SCIENTIFIC LITERATURE IN THE FIELD OF ENVIRONMENTAL MICROBIOLOGY
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20401668-2 -
MODULO 2
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Derived from
20401668-2 MODULO 2 in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 N0 CASALINO MARIA ASSUNTA
( syllabus)
- DURING LESSONS, THE FOLLOWING TOPICS WILL BE COVERED
- DISTRIBUTION AND ACTIVITY OF MICROORGANISMS IN MARINE, FRESHWATER AND TERRESTRIAL ECOSYSTEMS – EXTREME ENVIRONMENTS
-THE ROLE OF BACTERIA IN CYCLING ORGANICS. THE MOST WELL-KNOWN AND IMPORTANT BIOGEOCHEMICAL CYCLES: CARBON, NITROGEN SULFUR AND IRON CYCLES
-INTERACTION INVOLVIG MICRORGANISMS: COMPETITION, COMMENSALISM, MUTUALISM, PARASITISM, PREDACTION
- SENSING AND ADAPTIVE RESPONSES OF BACTERIA TO CHANGES IN DIFFERENT ENVIRONMENTAL CONDITIONS (changes in temperature, nutrients, pH, concentrations of ions)
- COMMUNICATION IN BACTERIA THROUGH THE EXCHANGE OF CHEMICAL SIGNAL MOLECULES:
-APPLICATION OF MOLECULAR TECHNOLOGIES CURRENTLY AVAILABLE FOR THE STUDY OF THE COMPOSITION AND DIVERSITY OF MICROBIAL COMMUNITIES
( reference books)
TEACHING MATERIAL:
- SELECTED TOPICS WILL BE AVAILABLE ON BROCK BIOLOGY OF MICROORGANISMS TEXTBOOK BY MADIGAN, MARTINKO AND PARKER
- SPECIFIC RESEARCH PAPERS WILL BE PROVIDED DURING THE COURSE
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20401668-1 -
MODULO 1
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Derived from
20401668-1 MODULO 1 in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 N0 CASALINO MARIA ASSUNTA
( syllabus)
- DURING LESSONS, THE FOLLOWING TOPICS WILL BE COVERED
- DISTRIBUTION AND ACTIVITY OF MICROORGANISMS IN MARINE, FRESHWATER AND TERRESTRIAL ECOSYSTEMS – EXTREME ENVIRONMENTS
-THE ROLE OF BACTERIA IN CYCLING ORGANICS. THE MOST WELL-KNOWN AND IMPORTANT BIOGEOCHEMICAL CYCLES: CARBON, NITROGEN SULFUR AND IRON CYCLES
-INTERACTION INVOLVIG MICRORGANISMS: COMPETITION, COMMENSALISM, MUTUALISM, PARASITISM, PREDACTION
- SENSING AND ADAPTIVE RESPONSES OF BACTERIA TO CHANGES IN DIFFERENT ENVIRONMENTAL CONDITIONS (changes in temperature, nutrients, pH, concentrations of ions)
- COMMUNICATION IN BACTERIA THROUGH THE EXCHANGE OF CHEMICAL SIGNAL MOLECULES:
-APPLICATION OF MOLECULAR TECHNOLOGIES CURRENTLY AVAILABLE FOR THE STUDY OF THE COMPOSITION AND DIVERSITY OF MICROBIAL COMMUNITIES
( reference books)
TEACHING MATERIAL:
- SELECTED TOPICS WILL BE AVAILABLE ON BROCK BIOLOGY OF MICROORGANISMS TEXTBOOK BY MADIGAN, MARTINKO AND PARKER
- SPECIFIC RESEARCH PAPERS WILL BE PROVIDED DURING THE COURSE
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20401669 -
EXPERIMENTAL MODELS IN BIOLOGY
(objectives)
THE COURSE PROVIDES BASICS CONCERNING THE EXPERIMENTAL MODELS MOST COMMONLY USED IN BIOLOGICAL RESEARCH.
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20401671 -
GENERAL PATHOLOGY
(objectives)
AIMS OF THE COURSE:
• TO ACQUIRE THE BASIC KNOWLEDGE ON THE HUMAN DISEASE CAUSES AND THEIR PATHOGENIC MECHANISMS.
• TO INTERPRET THE PATHOGENETIC AND PHYSIOPATHOGENIC MECHANISMS OF THE HUMAN DISEASES.
• TO KNOW THE OPERATIONS TURNED TO THE ANALYSIS OF THE PATHOGENETIC AND PHYSIOPATHOGENIC MECHANISMS OF THE HUMAN DISEASES AND TO INTERPRET THEIR RESULTS.
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MAINIERO FABRIZIO
( syllabus)
GENERAL AETIOLOGY. CONCEPTS OF HEALTH, PATHOLOGICAL PROCESS AND DISEASE; AETIOLOGY, PATHOGENESIS, EVOLUTION, DISEASE COURSE, OUTCOME.
ENVIRONMENTAL DISEASES. DISEASES CAUSED BY PHYSICAL AND CHEMICAL AGENTS
INFECTIOUS DISEASES. DISEASES CAUSED BY BIOLOGICAL AGENTS. BACTERIAL ESOTOXINS AND ENDOTOXINS. NEW MECHANISMS OF INFECTIOUS PATHOLOGY.
GENETIC DISEASES. DISEASES CAUSED BY GENETIC MUTATIONS. TRANSMISSIONS OF GENETIC DISEASES. TRANSMISSIONS OF MULTIFACTORIAL DISEASES. MAIN HUMAN DISEASES CAUSED BY KARYOTYPIC ANOMALIES.
PATHOLOGY OF THE CELL: MECHANISMS OF CELL DAMAGE AND ADAPTIVE CELL REACTIONS. MOLECULAR MECHANISMS OF CELL DAMAGE. HYPOXIC DAMAGE. OXIDATIVE STRESS: FREE RADICAL ORIGIN, LIPIDIC PEROXIDATION, PROTEIN AND DNA OXIDATION. ADAPTIVE CELL REACTIONS: HYPERTROPHY, HYPERPLASIA, ATROPHY. PHENOTYPIC CHANGES: METAPLASIA, DISPLASIA, ANAPLASIA. CELL DEGENERATION: HYDROPIC DEGENERATION; VACUOLAR DEGENERATION; EXCESSIVE DEPOSIT OF INTRACELLULAR MATERIAL, STEATOSIS. CELL DEATH: CELL NECROSIS AND APOPTOSIS. AGING.
INFLAMMATION. BASIC CONCEPTS: ACUTE AND CHRONIC INFLAMMATION; VASCULAR AND TISSUE INVOLVEMENT IN INFLAMMATION. RECEPTORS OF INNATE IMMUNITY AND INFLAMMATION. TRANSCRIPTIONAL PROGRAM IN INFLAMMATION. INFLAMMATORY CELLS. CHEMICAL MEDIATORS OF INFLAMMATION: CELLULAR AND HUMORAL ORIGIN. ACUTE INFLAMMATION: VASCULAR PHENOMENA, EXTRACELLULAR FLUIDS AND OEDEMA, DIFFERENT TYPES OF ACUTE INFLAMMATION. CHRONIC INFLAMMATION: GRANULOMA FORMATION. BODY GRANULOMAS. IMMUNOLOGICAL GRANULOMAS. SYSTEMIC EFFECTS OF INFLAMMATION AND THEIR REGULATION: ACUTE PHASE PROTEINS, RATE OF ERYTHROSEDIMENTATION, LEUKOCYTOSIS. PHYSIOPATHOLOGY OF TERMOREGULATION: FEVER. REGULATION OF INFLAMMATORY PROCESS.
REPAIR. PHASES OF TISSUE DAMAGE REPAIR. ANGIOGENESIS AND ANGIOGENETIC FACTORS. FIBROBLAST PROLIFERATION, EXTRACELLULAR MATRIX DEPOSITION AND INVOLVED FACTORS. REMODELLING. WOUND HEALING. HEALING OF FIRST AND SECOND INTENTION. PATHOLOGICAL ASPECTS OF WOUND HEALING: KELOIDS. REGENERATION: MODELS OF TISSUE REGENERATION. STEM CELLS.
ONCOLOGY: DEFINITIONS AND CLASSIFICATIONS. DEFINITIONS OF TUMORS AND PRE-CANCEROUS CONDITIONS. MORPHOLOGICAL AND BIOCHEMICAL CHARACTERISTICS OF NEOPLASTIC CELLS. HISTOGENETIC TUMOR CLASSIFICATIONS. CLINCIAL CRITERIA OF TUMOR CLASSIFICATIONS: GRADING AND STAGING. MOLECULAR AND GENETIC BASIS OF CANCER. PHYSIOPATHOLOGY OF CELL PROLIFERATION AND DIFFERENTIATION AND GROWTH FACTORS. PHYSICAL, CHEMICAL, VIRAL AND ORMONAL CANCEROGENESIS. IMMUNITY, INFLAMMATION AND TUMORS. ONCOGENES AND THEIR ACTIVATION. ONCOSUPPRESSOR GENES. GENOMIC INSTABILITY. HEREDITARY TUMORS. NEOPLASTIC PROCESS: INITIATION, PROMOTION AND PROGRESSION. MOLECULAR BASIS OF INVASIVENESS. METASTATIC SPREAD. FAVORING FACTORS FOR METASTATIC GROWTH.
PRIMARY METABOLIC DISEASES. BASIC CONCEPTS OF AMINOACID METABOLISM AND PHENYLKETONURIA, GLUCIDIC METABOLISM AND DIABETES, LIPIDIC METABOLISM AND DYSLIPIDEMIAS.
GENERAL PATHOPHYSIOLOGY: PATHOPHYSIOLOGY OF METABOLISM (AMINO ACIDS, PURINE AND PIRIMIDINICHE, LIPID AND DYSLIPIDEMIA).
GENERAL PHYSIOPATHOLOGY OF HAEMATOPOIEC ORGANS AND HAEMOSTASIS.
( reference books)
PATOLOGIA GENERALE, G.M. PONTIERI ET AL., VOL I, VOL II, PICCIN, 2010
PATOLOGIA GENERALE-PATOLOGIA D’ORGANO E MOLECOLARE, R. RUBIN ET AL, PICCIN, 2014
PATOLOGIA GENERALE CON ELEMENTI DI FISIOPATOLOGIA. ROBBINS, ED. EDRA 2013
FURTHER READING
LE BASI PATOLOGICHE DELLE MALATTIE, ROBBINS, VIII ED., VOL I, ELSEVIER, 2010
(IX EDIZIONE IN USCITA NEL 2015)
PATOLOGIA, STEVENS, J. LOWE, III ED., CASA ED. AMBROSIANA, 2010
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20401777 -
PUBLIC HEALTH
(objectives)
General objectives
At the end of the course the student will be able to design epidemiological studies to address public health problems and to identify activities to prevent chronic and infectious diseases.
Specific objectives
- to know the major mortality and morbidity indicators
- to identify the more appropriate epidemiological study to describe the burden of major diseases in the population and to assess the relation between diseases and possible risk factors associated to them
- to interpret epidemiological data
- to discuss the importance of the health education and health promotion
- to list and discuss problems related to water supply, sanitation and waste management
- to argue about necessary controls/monitoring to protect the environment and the community
- to design health promotion programmes
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MED/42
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20401782 -
MOLECULAR BIOTECHNOLOGY
(objectives)
THE AIM OF THE COURSE IS TO PROVIDE METHODOLOGIES AND TECHNOLOGIES KNOWLEDGE OF BASIC AND APPLIED ADVANCED RESEARCH IN MOLECULAR BIOTECHNOLOGIES.
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20401782-2 -
MODULO 2
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CERVELLI MANUELA
( syllabus)
1. BASIC TECHNOLOGIES OF GENE ANALYSIS; RESTRICTION ENZYMES; ELECTROPHORETIC ANALYSIS. 2. VECTORS; CLONING. 3. PCR; REAL TIME PCR; PCR APPLICATIONS. 4. GENETIC VARIABILITY APPLIED TO FORENSIC SCIENCE 5. GENE IDENTIFICATION; GENOMIC LIBRERIES AND cDNA LIBRERIES; YEAST TWO HYBRID SYSTEM 6. MUTAGENESIS. 7. RECOMBINANT PROTEIN PRODUCTION AND PURIFICATION. 8. FROM SANGER SEQUENCING TO NEXT-GENERATION SEQUENCING. 9. POST-GENOMICS ANALYSIS; TRANSCRIPTOMIC ANALYSIS; REPORTER GENES. 10. PROTEOMIC ANALYSIS. 11. PRODUCTION AND ANALYSIS OF TRANSGENIC PLANTS. 12. GENETIC MODIFICATION OF ANIMAL CELLS; TRANSGENIC ANIMALS CONSTRUCTION. 13. GENE TRAPPING; GENE TARGETING. 14. ANIMAL CLONING; GENE THERAPY. 15. THE CRISPR-CAS SYSTEM: EMERGING TECHNOLOGY AND APPLICATION AND APPLICATIONS.
( reference books)
Recommended textbooks:1. ANALISI DEI GENI E GENOMI, REECE, EDISES.2. DNA RICOMBINANTE, J.D.WATSON, A.A. CAUDY, R.M. MYERS E J.A. WITKOWSKI, ZANICHELLI.Lecture slides will be provided.The professor receives every day from 10.00 to 11.00 by appointment via e-mail: manuela.cervelli@uniroma3.it
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20401782-1 -
MODULO 1
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CERVELLI MANUELA
( syllabus)
1. BASIC TECHNOLOGIES OF GENE ANALYSIS; RESTRICTION ENZYMES; ELECTROPHORETIC ANALYSIS. 2. VECTORS; CLONING. 3. PCR; REAL TIME PCR; PCR APPLICATIONS. 4. GENETIC VARIABILITY APPLIED TO FORENSIC SCIENCE 5. GENE IDENTIFICATION; GENOMIC LIBRERIES AND cDNA LIBRERIES; YEAST TWO HYBRID SYSTEM 6. MUTAGENESIS. 7. RECOMBINANT PROTEIN PRODUCTION AND PURIFICATION. 8. FROM SANGER SEQUENCING TO NEXT-GENERATION SEQUENCING. 9. POST-GENOMICS ANALYSIS; TRANSCRIPTOMIC ANALYSIS; REPORTER GENES. 10. PROTEOMIC ANALYSIS. 11. PRODUCTION AND ANALYSIS OF TRANSGENIC PLANTS. 12. GENETIC MODIFICATION OF ANIMAL CELLS; TRANSGENIC ANIMALS CONSTRUCTION. 13. GENE TRAPPING; GENE TARGETING. 14. ANIMAL CLONING; GENE THERAPY. 15. THE CRISPR-CAS SYSTEM: EMERGING TECHNOLOGY AND APPLICATION AND APPLICATIONS.
( reference books)
Recommended textbooks:1. ANALISI DEI GENI E GENOMI, REECE, EDISES.2. DNA RICOMBINANTE, J.D.WATSON, A.A. CAUDY, R.M. MYERS E J.A. WITKOWSKI, ZANICHELLI.Lecture slides will be providedThe professor receives every day from 10.00 to 11.00 by appointment via e-mail: manuela.cervelli@uniroma3.it
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20401786 -
GENERAL ENTOMOLOGY
(objectives)
THE MAIN FORMATIVE TARGETS ARE: 1) THE ACQUISITION OF A BASIC KNOWLEDGE ON MORPHOLOGY, ANATOMY, PHYSIOLOGY AND EVOLUTION OF THE MAIN INSECT GROUPS. 2) THE ACQUISITION OF BOTH THEORETICAL AND PRACTICAL KNOWLEDGE ON SYSTEMATICS AND CLASSIFICATION OF THE HEXAPODA. 3) THE CONSTRUCTION OF A SOLID CULTURAL BACKGROUND FOR AN ADVANCED DISCUSSION ON CAUSES AND EFFECTS OF THE AMAZING EVOLUTIONARY SUCCESS AND DIVERSITY OF INSECTS AND ON THEIR IMPORTANCE IN BASIC AND APPLIED STUDIES. 4) THE ACQUISITION OF THE TOOLS FOR THE INSECT TAXONOMIC IDENTIFICATION, EXPECIALLY FOR THOSE ORDERS AND FAMILIES PRESENT IN THE ITALIAN FAUNA. 5) TO STIMULATE THE CURIOSITY AND THE ABILITY OF CRITICALLY OBSERVE THE NATURE. 6) THE SELF-EVALUATION BY THE STUDENT OF THE COMPETENCE WHITIN THE ANIMAL BIOLOGY, AND IN PARTICULAR IN THE ENTOMOLOGY.
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20401786-2 -
MODULO 2
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Derived from
20401786 ENTOMOLOGIA in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 (docente da definire)
( syllabus)
PART 1) BASIC AND APPLIED ENTOMOLOGY. ARTHROPOD PHYLOGENY. ORIGIN, CAUSES AND SIGNIFICANCE OF THE INSECT SUCCESS AND DIVERSITY. INTEGUMENT; STRUCTURE OF THE INTEGUMENT AND CUTICLE; COLORS. BODY REGIONS; SCLERITES; SEGMENTS, APPENDICES AND WINGS. MUSCULATURE AND ENDOSCHELETON; ADAPTATION TO THE MOVEMENT IN AERIAL AND ACQUATIC ENVIROMENTS. RESPIRATORY APPARATUS AND RESPIRATION; RESPIRATION IN WATER. EXCRETION. CEPHALIC APPENDAGES AND MOUTHPARTS; ANATOMY AND PHYSIOLOGY OF THE DIGESTIVE SYSTEM; FEEDING STRATEGIES. CIRCULATORY SYSTEM AND BLOOD. REPRODUCTION: STRUCTURE AND FUNCTIONAL MORPHOLOGY OF SEGMENTS AND GENITAL TRAITS; REPRODUCTIVE BEHAVIORS; EGGS; SPERMS. EMBRYONIC AND POSTEMBRYONIC DEVELOPMENT. ENDOCRINE SYSTEM: HORMONS AND ENDOCRIN ORGANS. HEXOCRIN GLANDS. NERVOUS SYSTEM AND SENSE ORGANS. SIMPLE AND COMPOUND EYES. PRODUCTION OF LIGHT AND SOUNDS. CRIPTISM AND MIMICRY. PHEROMONS AND COURTSHIP; PARENTAL CARES; INSECT SOCIETIES. PREDATION; PARASITISM; SYMBIOSIS. ORIENTATION; MIGRATIONS; DISPERSION. INSECT BIOGEOGRAPHY. INSECT CONSERVATION.PART 2) INSECT PHYLOGENY. CLASSIFICATION: DIAGNOSTIC CHARACTERS AT ORDER AND MAIN FAMILY LEVEL (ESPECIALLY TO THOSE PRESENT IN ITALY). METHODS OF STUDY, COLLECTION, PREPARATION AND PRESERVATION.THE SECOND PART OF THE COURSE INCLUDES, DURING THE LESSONS PERIOD, FOUR LABORATORY PRACTICES (EACH OF CA. TWO HOURS) AND TWO DAILY FIELD PRACTICE (ONE IN THE MIDDLE AND ONE AT THE END OF THE COURSE). LAB PRACTICAL ACTIVITIES CONCERN THE EXAMINATION OF SLIDES AND PRESERVED SPECIMENS BELONGING TO THE MAIN ORDERS AND FAMILIES; SOME ANATOMICAL DISSECTIONS WILL BE ALSO PERFORMED. THE FIELD EXPERIENCE IS AIMED TO SHOW SPECIES DIVERSITY AND ECOLOGICAL ASSEMBLAGES OF BOTH TERRESTRIAL AND WATER INSECTS, SHOWING THE MOST COMMON METHODS OF SAMPLING.
( reference books)
P.J. GULLAN & P.S. CRANSTON “LINEAMENTI DI ENTOMOLOGIA” ZANICHELLI orR.G. DAVIES “LINEAMENTI DI ENTOMOLOGIA” ZANICHELLI OTHER TEXTBOOKS (THE CHOICE HAS TO BE DISCUSSED WITH THE PROFESSOR):G. GRANDI “ISTITUZIONI DI ENTOMOLOGIA GENERALE” EDIZIONI CALDERINIV.B. WIGGLESWORTH “LA VITA DEGLI INSETTI” GARZANTI R.F. CHAPMAN “THE INSECTS: STRUCTURE AND FUNCTION” HODDER & STOUGHTON, LONDON C. GILLOT “ENTOMOLOGY” PLENUM PRESS, NEW YORK O.W. RICHARDS & R.G. DAVIES “IMM’S GENERAL TEXTBOOK OF ENTOMOLOGY” CHAPMAN & HALL, LONDON VOL. I AND IIGENERAL INSECT GUIDES (STUDENT CHOICE) ARE RECOMMENDED FOR BOTH LAB AND FIELD ACTIVITIES AS WELL AS FOR THE STUDY OF THE SYSTEMATIC PART OF THE COURSE.
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MODULO 1
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Derived from
20401786 ENTOMOLOGIA in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 (docente da definire)
( syllabus)
1) Introduction: aim of the course; entomology in the history of Zoology and more generally in the history of science; role of entomology in modern biological disciplines; basic and applied entomology; relationships of insects with man and the environment.2) Generalities on Arthropods; phylogenesis problems of Arthropods; insects in the evolution of terrestrial Arthropods; general information on the Atelocerata, and in particular on the Hexapods; outline of paleontology of insects; insect origin; significance of the evolutionary success of insects.3) Insects as land animals; exoskeleton; structure of the integument and cuticle; chemical and physical colors. External anatomy: regions of the body; sclerites; primary and secondary segmentation; appendices and wings.4) Movement: musculature and endoskeleton; the race; the jump; origin and mechanics of flight; adaptations to aquatic life and importance of surface forces, swimming; the excavation; raptorial and phoretic limbs.5) Breathing; breathing in the aquatic environment; water reabsorption; excretion; adaptations to temperature changes.6) Nutrition: cephalic appendages and mouthparts; anatomy and physiology of the digestive system; food strategies.7) Circulatory system.8) Reproduction: structure and functional morphology of the segments and genital appendages; reproductive systems and reproductive behaviors; parthenogenesis; pedogenesis; polyembryony; meaning of heterogony; eggs; sperm.9) Embryonic and postembryonic development: growth and metamorphosis; types of larvae and types of metamorphosis; diapause; physiology; endocrine glands.10) Communication in insects. Nervous system: components and functioning. Endocrine system: hormones and endocrine organs. Exocrine glands. Perception of the environment. Compound eyes. Vision. Ocelli. Mechanoreceptors. Coloration. Light production. Mechanical communication: production of sound and vibrations of the substrate. Chemical communication: pheromones and secretions of interspecific significance.11) Intraspecific relationships; parental care; society; interspecific relationships; predation; parasitism.12) Orientation; migrations; dispersion.13) Aspects of applied entomology: medical entomology, agricultural entomology, entomology in environmental assessment, insect conservation, urban entomology, veterinary entomology, entomology applied to conservation of cultural heritage.
( reference books)
P.J. Gullan & P.S. Cranston “Lineamenti di Entomologia” Zanichelli R.G. Davies “Lineamenti di Entomologia” Zanichelli G. Grimaldi “Evolution of the Insects”R.F. Chapman “The Insects: structure and function” Hodder & Stoughton, London C. Gillot “Entomology” Plenum Press, New York O.W. Richards & R.G. Davies “Imm’s general textbook of entomology” Chapman & Hall, London Vol. I e II M. Chinery “Guida agli insetti d’Europa” Muzzio Office Hours: every day of the week by appointment by email (andrea.digiulio@uniroma3.it)
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20401787 -
ETHNOBOTANY AND ETHNOZOOLOGY
(objectives)
ANALYSIS OF ECOLOGICAL AND CULTURAL RELATIONS BETWEEN HUMANS AND LIVING BEINGS, THROUGH AN HISTORICAL AND GEOGRAPHIC SURVEY AT DIFFERENT LEVELS OF CIVILIZATION. PERSPECTIVES OF THE RECOVERY OF POPULAR TRADITIONS.
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20401788 -
STRATEGIC ENVIRONMENTAL ASSESSMENT
(objectives)
TO PROVIDE THE BASICS IN TERMS OF TECHNICAL, LEGAL, SCIENTIFIC AND CULTURAL ISSUES ON ENVIRONMENTAL ASSESSMENT TOOLS, WITH PARTICULAR REFERENCE TO THE ENVIRONMENTAL IMPACT ASSESSMENT, THE STRATEGIC ENVIRONMENTAL ASSESSMENT, THE ASSESSMENT OF IMPACTS, THE INDICATORS FOR THE MONITORING AND REPORTING OF ENVIRONMENTAL . THE KNOWLEDGE ACQUIRED BY THE STUDENTS, INTEGRATED WITH THE CONTENT OF OTHER COURSES WITHIN THE DEGREE COURSE (TECHNICAL CARTOGRAPHIC AND GIS, STATISTICS, APPLIED ECOLOGY, MANAGEMENT OF ECOSYSTEMS, BIODIVERSITY, ETC..) CONTRIBUTES TO DEVELOP PROFESSIONAL FIGURES IN ENVIRONMENTAL MONITORING.
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20401821 -
IMMUNOLOGY
(objectives)
TO DEEPLY UNDERSTAND CELLULAR AND MOLECULAR MECHANISMS OF IMMUNE RESPONSE AND THEIR ROLE IN HEALTH AND DISEASE.
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DI ROSA FRANCESCA
( syllabus)
LYMPHOID ORGANS: BONE MARROW, THYMUS, LYMPH NODES AND LYMPHATIC SYSTEM, SPLEEN, MUCOSE ASSOCIATED LYMPHOID SYSTEM.
B LYMPHOCYTE DEVELOPMENT: SELECTION AND MATURATION OF B CELLS. IMMUNOGLOBULIN STRUCTURE AND IMMUNOGLOBULIN GENE REARRANGEMENT.
T LYMPHOCYTE DEVELOPMENT: SELECTION AND MATURATION OF T CELLS. TCR STRUCTURE AND TCR GENE REARRANGEMENT.
ANTIGEN PRESENTING CELLS AND INNATE IMMUNITY RECEPTORS.
MHC: GENES AND PROTEINS. ANTIGEN PROCESSING.
INDUCTION OF PRIMARY RESPONSE: DENDRITIC CELL ACTIVATION, INDUCTION OF ANTIGEN-SPECIFIC RESPONSE OF T AND B LYMPHOCYTES.
CYTOKINES: GENERAL CHARACTERISTICS CYTOKINES REGULATING INNATE IMMUNITY, CYTOKINES REGULATING ANTIGEN-SPECIFIC IMMUNITY. IL-1 SUPERFAMILY, INFLAMMOSOME; TNF SUPERFAMILY.
CHEMOKINES: GENERAL CHARACTERISTICS, INFLAMMATORY AND HOMEOSTATIC CHEMOKINES.
IMMUNITY AGAINST INFECTIONS. IMMUNOLOGICAL MEMORY AND VACCINES.
TOLERANCE AND AUTOIMMUNITY: CENTRAL AND PERIPHERAL TOLERANCE, BREKING OF TOLERANCE, AUTOIMMUNITY AND DISEASES.
ALLERGIES: CAUSES AND TYPES OF HYPERSENSIBILITY DISEASES.
PRIMARY AND SECONDARY IMMUNODEFICIENCIES: GENERAL CHARACTERISTICS, CLASSIFICATION, GENE THERAPY EXAMPLES. MAIN CONCEPTS ON ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS).
TUMORS AND IMMUNITY: TUMORAL ANTIGENS, IMMUNE RESPONSE TO TUMORS, IMMUNOTHERAPY AND VACCINATION AGAINST TUMORS.
TRANSPLANTATION: ANTI-GRAFT IMMUNE RESPONSE, EFFECTOR MECHANISMS, BIOTECHNOLOGICAL TOOLS FOR INTERVENTION.
( reference books)
K. MURPHY. , IMMUNOBIOLOGIA DI JANEWAY , 8° EDIZIONE, PICCIN, 2012.
A.K. ABBAS, A. H. LICHTMAN, S. PILLAI , IMMUNOLOGIA CELLULARE E MOLECOLARE , 7° EDIZIONE, ELSEVIER MASSON, 2012.
TAK. W. MAK, M. SAUNDERS, FONDAMENTI DI IMMUNOLOGIA, ZANICHELLI, 2012
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20401875 -
METHODS AND TECHNIQUES OF EDUCATION AND PROMOTION OF NATURALISTIC AND ENVIRONMENTAL ISSUES
(objectives)
Students’ grow in knowledge, skills and abilities in order to become a professional in the fields of education and naturalistic and environmental dissemination.
Making students aware of the professions related to dissemination and education in the field of nature and environment as potential job opportunities for specialists of management and protection of ecosystems.
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20401990 -
CELLULAR BIOCHEMISTRY
(objectives)
The aim of the course is to introduce students to the “inorganic biofactors”, starting from their biochemical role to the analysis of their impact on human health. In the second part of the course we will focus on the “omics”, which represents a broad discipline of science (from trascriptomics to metabolomics) intended for analyzing system biology and for characterizing the biochemical events associated to transcripts, proteins and metabolites variations in fluids, organs and tissues.
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DI MASI ALESSANDRA
( syllabus)
HEME-PROTEINS. HEME METABOLISM AND RELATED DISEASES. HEME BIOSYNTHESIS AND RELATED DISEASES. IRON METABOLISM AND RELATED DISEASES. INORGANIC BIOFACTORS: OXYGEN, CARBON MONOXIDE, NITROGEN MONOXIDE, HYDROGEN SULFIDE. BIOCHEMICAL AND CELLULAR ROLES OF THE INORGANIC BIOFACTORS. ROLE IOF THE INORGANIC BIOFACTORS IN HUMANN DISEASES ONSET. THE THERAPEUTIC USE OF THE INORGANIC BIOFACTORS. REACTIVE OXYGEN AND NITROGEN SPECIES. MITOCHONDRIAL DISEASES. THE ENERGETIC MATTER OF CANCER CELLS. THE METABOLIC REQUIREMENTS OF CANCER CELLS: THE WARBURG EFFECT.
( reference books)
SCIENTIFIC PAPERS SUPPLIED BY THE TEACHER.
Support texts:
Siliprandi & Tettamanti "Biochimica Medica - strutturale, metabolica e funzionale" Ed. Piccin
- Chiurchiù & Maccarrone "I radicali liberi e la loro rilevanza in biomedicina: dai meccanismi molecolari alle prospettive terapeutiche" Ed Piccin
RECEPTION TIME: Monday 10 am
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POLTICELLI FABIO
( syllabus)
DEFINIZIONE DI “INORGANIC BIOFACTORS”. I PRINCIPALI “INORGANIC BIOFACTORS”: L’OSSIGENO MOLECOLARE, IL MONOSSIDO DI CARBONIO, IL MONOSSIDO D’AZOTO, L’ACIDO SOLFIDRICO, LE SPECIE REATTIVE DELL’OSSIGENO E DELL’AZOTO. ANALISI DEL LORO RUOLO BIOCHIMICO E CELLULARE. RUOLO NELLA SALUTE DELL’UOMO.
LE “OMICS” COME STRUMENTI PER LO STUDIO DELLA BIOLOGIA DEI SISTEMI E PER LA CARATTERIZZAZIONE DEGLI EVENTI BIOCHIMICI ASSOCIATI ALLO STATO DI SALUTE O DI MALATTIA. LA TRASCRITTOMICA, LA PROTEOMICA, LA METABOLOMICA E L’INTERATTOMICA: METODI SPERIMENTALI E POTENZIALITÀ APPLICATIVE IN DIVERSI SISTEMI BIOLOGICI (MICROORGANISMI, LINEE CELLULARI, MODELLI ANIMALI). LE “OMICS” COME METODO DI STUDIO DI PATOLOGIE UMANE: “INTERPLAY” DI FATTORI GENETICI, FARMACOLOGICI E PATOLOGICI NEL MANTENIMENTO DELL’OMEOSTASI CELLULARE.
( reference books)
ARTICOLI SCIENTIFICI, SUPPORTI INFORMATICI E CARTACEI FORNITI DAL DOCENTE..
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20401992 -
MICROBIAL BIOTECHNOLOGY LABORATORY
(objectives)
THE MAIN AIMS OF THE COURSE ARE:
A) ACQUISITION OF APPROPRIATE METODOLOGIES AND LANGUAGES FOR THE ISOLATION, OBSERVATION AND DESCRIPTION OF INDUSTRIAL MICROORGANISMS
B) ACQUISITION OF THE BASIC KNOWLEDGE FOR THE DRAFTING AND EXECUTION OF AN EXPERIMENTAL PROTOCOL
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20401992-2 -
MODULO 2
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RAMPIONI GIORDANO
( syllabus)
The course aims at providing to the student:- adequate knowledge and understanding on advanced methodologies in microbial biotechnology, appropriate methodologies and communication skills for the isolation, observation, description and engineering of industrial microorganisms;- adequate applied knowledge for drafting and executing experimental protocols, and for retrieving and critically reviewing relevant scientific literature from on-line databases (making judgements).ProgrammeDuring the laboratory practices and the corresponding theoretic lessons, the following topics will be covered:- isolation of microorganisms of industrial relevance from the environment, preparation of growth media and cultivation techniques;- transposon–based mutagenesis (generation and screening of mutant libraries);- genetic transfer processes (conjugation and transformation);- use of whole-cell bacterial biosensors for gauging specific molecules produced by other microorganisms.The following topics will be covered in additional theoretic lessons: - development of innovative therapeutic strategies based on biotechnological processes;- development of biosensors and reporter systems for the identification of new drugs;- application of synthetic biology to microbial biotechnology;- properties of the regulatory networks and their application to biotechnological processes.
( reference books)
Selected topics will be available on suggested Microbiology and Microbial Biotechnology books, as indicated in the following reference list. Specific research papers and experimental protocols will be provided during theoretic lessons on advanced research topics and laboratory practices. Innovative teaching will be promoted by cloud-sharing of power-point presentations illustrating the main topics of the course. Moreover, students will be encouraged to make use of web-based resources and databases to autonomously increase their knowledge on specific advanced topics.Students will be received every Monday, from 3:00 to 4:00 pm. Students can be received at the best of their convenience if an appointment has been fixed at the end of the lessons or by email.
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LEONI LIVIA
( syllabus)
The course aims at providing to the student:- adequate knowledge and understanding on advanced methodologies in microbial biotechnology, appropriate methodologies and communication skills for the isolation, observation, description and engineering of industrial microorganisms;- adequate applied knowledge for drafting and executing experimental protocols, and for retrieving and critically reviewing relevant scientific literature from on-line databases (making judgements).During the laboratory practices and the corresponding theoretic lessons, the following topics will be covered:- isolation of microorganisms of industrial relevance from the environment, preparation of growth media and cultivation techniques;- transposon–based mutagenesis (generation and screening of mutant libraries);- genetic transfer processes (conjugation and transformation);- use of whole-cell bacterial biosensors for gauging specific molecules produced by other microorganisms.The following topics will be covered in additional theoretic lessons: - development of innovative therapeutic strategies based on biotechnological processes;- development of biosensors and reporter systems for the identification of new drugs;- application of synthetic biology to microbial biotechnology;- properties of the regulatory networks and their application to biotechnological processes.
( reference books)
Selected topics will be available on suggested Microbiology and Microbial Biotechnology books, as indicated in the following reference list. Specific research papers and experimental protocols will be provided during theoretic lessons on advanced research topics and laboratory practices. Innovative teaching will be promoted by cloud-sharing of power-point presentations illustrating the main topics of the course. Moreover, students will be encouraged to make use of web-based resources and databases to autonomously increase their knowledge on specific advanced topics.Students will be received every Monday, from 3:00 to 4:00 pm. Students can be received at the best of their convenience if an appointment has been fixed at the end of the lessons or by email.
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20401992-1 -
MODULO 1
-
RAMPIONI GIORDANO
( syllabus)
The course aims at providing to the student:- adequate knowledge and understanding on advanced methodologies in microbial biotechnology, appropriate methodologies and communication skills for the isolation, observation, description and engineering of industrial microorganisms;- adequate applied knowledge for drafting and executing experimental protocols, and for retrieving and critically reviewing relevant scientific literature from on-line databases (making judgements).ProgrammeDuring the laboratory practices and the corresponding theoretic lessons, the following topics will be covered:- isolation of microorganisms of industrial relevance from the environment, preparation of growth media and cultivation techniques;- transposon–based mutagenesis (generation and screening of mutant libraries);- genetic transfer processes (conjugation and transformation);- use of whole-cell bacterial biosensors for gauging specific molecules produced by other microorganisms.The following topics will be covered in additional theoretic lessons: - development of innovative therapeutic strategies based on biotechnological processes;- development of biosensors and reporter systems for the identification of new drugs;- application of synthetic biology to microbial biotechnology;- properties of the regulatory networks and their application to biotechnological processes.
( reference books)
Selected topics will be available on suggested Microbiology and Microbial Biotechnology books, as indicated in the following reference list. Specific research papers and experimental protocols will be provided during theoretic lessons on advanced research topics and laboratory practices. Innovative teaching will be promoted by cloud-sharing of power-point presentations illustrating the main topics of the course. Moreover, students will be encouraged to make use of web-based resources and databases to autonomously increase their knowledge on specific advanced topics.Students will be received every Monday, from 3:00 to 4:00 pm. Students can be received at the best of their convenience if an appointment has been fixed at the end of the lessons or by email.
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LEONI LIVIA
( syllabus)
Programma (ENG)The course aims at providing to the student:- adequate knowledge and understanding on advanced methodologies in microbial biotechnology, appropriate methodologies and communication skills for the isolation, observation, description and engineering of industrial microorganisms;- adequate applied knowledge for drafting and executing experimental protocols, and for retrieving and critically reviewing relevant scientific literature from on-line databases (making judgements).ProgrammeDuring the laboratory practices and the corresponding theoretic lessons, the following topics will be covered:- isolation of microorganisms of industrial relevance from the environment, preparation of growth media and cultivation techniques;- transposon–based mutagenesis (generation and screening of mutant libraries);- genetic transfer processes (conjugation and transformation);- use of whole-cell bacterial biosensors for gauging specific molecules produced by other microorganisms.The following topics will be covered in additional theoretic lessons: - development of innovative therapeutic strategies based on biotechnological processes;- development of biosensors and reporter systems for the identification of new drugs;- application of synthetic biology to microbial biotechnology;- properties of the regulatory networks and their application to biotechnological processes.
( reference books)
Selected topics will be available on suggested Microbiology and Microbial Biotechnology books, as indicated in the following reference list. Specific research papers and experimental protocols will be provided during theoretic lessons on advanced research topics and laboratory practices. Innovative teaching will be promoted by cloud-sharing of power-point presentations illustrating the main topics of the course. Moreover, students will be encouraged to make use of web-based resources and databases to autonomously increase their knowledge on specific advanced topics. Students can be received at the best of their convenience if an appointment has been fixed at the end of the lessons or by email.
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20402204 -
BIO-ORGANIC CHEMISTRY
(objectives)
The course will address the chemical transformations shared by organic chemistry and biological systems. Indeed, although the functional group elaborations are formally the same, the followed reaction pathways result to be quite different with respect to the experimental conditions of both organic syntheses and biological processes. In such a context, the enzymatic action modes in living systems will be compared with the key role performed by temperature, pressure, pH, catalysts and solvents. Keeping this in mind, a few of the most well-known chemical reaction mechanisms will be studied, underlining, step by step, the main similarities and distinctions with the analogous biological transformations
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GASPERI TECLA
( syllabus)
Cultural skills: the course aims to provide students with the chemical basis of the structure, the properties, and the reactivity of biological molecules, as well as the main notions for understanding the logic that regulates bio-organic chemistry processes.
Methodological skills: at the end of the course, the student will be able to analyze and discuss the catalytic mechanism of the most important classes of enzymes, as well as to understand the importance of the organic chemistry applied to the study of biological systems, to biocatalysis, and to the development of biologically active molecules.
Introduction to Bio-organic Chemistry (A short overview about the most common functional groups involved in biological processes, highlighting their main features).
Organic chemistry mechanisms to explain key steps in pivotal biological pathways:
• Electrophilic Addition Reactions:
regioselective epoxidation of alkenes; the action of squalene epoxidase in squalene/lanosterol transformation.
• Nucleophilic Substitution Reactions
bimolecular Nucleophilic Substitution Reaction (SN2): the S-adenosylmethionine (SAM) role in the methyltransferase-catalyzed reactions;
carbocation chemistry in the nucleophilic substitution reaction (SN1): the IPP isomerase.
• Elimination reactions:
β-elimination reaction and the enolase role in the synthesis of the phosphoenol pyruvate (PEP).
• Nucleophilic Carbonyl Addition Reactions
imine and enamine formation; how Schiff bases act in the PLP-dependent enzymatic catalysis;
acetals and sucrose synthase;
Michael additions and the histidine ammonia-lyase function.
• Isomerization and epimerization:
keto-enol tautomerism and ribose-5-phosphate isomerase catalysis;
Inversion and retention of the stereochemical configuration: the glucosidase mechanism.
• Carbonyl condensation reactions:
aldol condensation promoted by aldolases (classes I and II)
Claisen condensation and the acetyl synthase function in the fatty acids synthesis.
• Acyl Nucleophilic Substitutions:
the hydrolysis of esters and the mechanism of Human Pancreatic Lipase;
esterification reactions and the synthesis of triacylglycerols by means of acyl-CoA synthetase and acyltransferase;
amide bond formation; asparagine synthetase vs glutamine synthetase;
the hydrolysis of amides and the chymotrypsin action mode.
• Oxidations and reductions
metal hydride and the reduction of the ketone carbonyl group in acetoacetyl ACP due to the β-keto thioester reductase;
Baeyer-Villinger oxidation and the hydroxyacetophenone monooxygenase;
ozonolysis reactions and the dioxygenase enzyme activity.
• Carboxylation reactions:
Grignard reactions in CO2 atmosphere; mechanisms of both the pyruvate carboxylase and Ribulose-1,5-bisphosphate carboxylase oxygenase (RuBiscO);
the decarboxylation reaction in both malonic and acetoacetic synthesis; the key role of thiamine pyrophosphate (TPP) in the 1-deoxy-D-xylulose 5-phosphate synthase catalysis.
• Noteworthy examples: pyruvate dehydrogenase complex, the kynurenine catalysis and the tryptophan metabolism; anomalous features in in histidine metabolism.
( reference books)
Textbook: John McMurry, Tadhg Begley in “Chimica Bio-Organica”, Zanichelli Ed. spa
Others: T.W. Graham Solomons; Craig B. Fryhle in “Organic Chemistry”, 10th Edition, Wiley.
John McMurry in “Chimica Organica”, Piccin-Nuova Libreria
Papers from the current literature
Notes from the teacher
The teacher receives Tuesday from 17.00 to 19.00 by appointment via e-mail: tecla.gasperi@uniroma3.it
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22402256 -
EVOLUTIONARY PARASITOLOGY
(objectives)
Offering the students a new perspective in the study of parasitology, by means of an ecological- evolutionary and comparative approach. The intimate and intricate nature of the association between host and parasite, has traditionally been studied by giving emphasis on its pathogeniticy for non human animal and human hosts. In contrast, this course offers the student the opportunity to deepen topics such as adaptive strategies of parasitic life-style, the impact of parasitism on the community structure or else the role of a parasite in the trophic energy transfer in the community. Emphasis will be given to the host as key element in the parasite environment and, as such, its important role as a selective pressure. The student will be provided with a dynamic course made of lectures, workshops and tutorials on taxa parasites
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22402256-1 -
MODULO 1
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Derived from
22402256 PARASSITOLOGIA EVOLUZIONISTICA in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 (docente da definire)
( syllabus)
• Symbiotic interactions (phoresy, commensalism, exploitation, mutualism). Parasitism: definitions. Exploitation and trophic interactions: distinct adaptive strategies (predator/prey, parasitoid/prey, micropredators, parasite/host). Kinds of parasites: endo- and ecto-parasites, micro- and macro-parasites, obligate and facultative parasites, hyperparasites. Kinds of hosts: definitive and intermediate hosts, vectors, paratenic (transport) hosts, reservoire hosts. Mechanisms of invasion, evasion, and survival, transmission strategies. Protozoa and main Metazoan parasites: Platyhelminthes, Nematoda, Acanthocephala, Pentastomida, Arthropoda; pararitism in other metazoan groups.• Evolutionary parasitology. Origins of parasitism and transition to parasitism from a free-living ancestral life-style; resistance against the host's defense mechanisms and evolution of host specificity; complex life-cycles shaped by historical events and selective pressures; hosts as part of parasite environment and as a source of selective pressure. Host manipulation by parasites (e.g. behavioral alterations in parasitized hosts). Development of resistance, tolerance and life-history parameters in host species. Host-parasite coevolution: an evolutionary arms race and the “Red-queen” hypothesis. • Evolutionary ecology of parasites. How complex life cycles have influenced the ecology of parasites. Evolutionary ecology of parasites at different hierarchical levels: individual, population, and community ecology. Parasitism and community structure in natural ecosystems. Parasites as ubiquitous components of ecosystems. Parasite’s influence on survival and reproduction of individual hosts, on the dynamics of host populations, and on the structure of entire communities. (A) parasites alter the flow of energy through a food web by converting host tissue into parasite tissue and (B) parasite-increased trophic transmission alters predator-prey dynamics by making infected prey easier to capture.• Cladogenesis of parasitic taxa and co-speciation of parasite and host species. Phylogeny and ecology of host and parasite: how phylogeny may provide insights into the evolution of host and parasite associations, and how ecological data may provide insights into phylogenetic relationships. Causes of diversity in parasite life-history traits: role of selective pressure from hosts and physical environments, and role of phylogenetic constraints• The biogeography of the host-parasite interaction.
( reference books)
Reference Texts and Atlas- Parasitism: The Ecology and Evolution of Intimate Interactions, Claude Combes, 2004, University of Chicago Press (ISBN: 9780226114460)- Evolutionary Evolutionary Ecology of Parasites, (Second Edition), Robert Poulin, 2006, Princeton University Press (ISBN: 9780691120850)- Parasitism: The Diversity and Ecology of Animal Parasites, Albert O. Bush, Jacqueline C. Fernández, Gerald W. Esch, J. Richard Seed, 2001, Cambridge University Press (ISBN-13: 978-0521664479)- Atlante di parassitologia, Frank Werner; Lieder Johannes, 2002, Franco Muzzio Editore (collana Scienze naturali), 3° edizione (ISBN: 978887413029)- Manuale di parassitologia veterinaria, Genchi Marco; Traldi Giorgio; Genchi Claudio, 2010, Editore CEA (ISBN-10: 8808183483)
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22402256-2 -
MODULO 2
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Derived from
22402256 PARASSITOLOGIA EVOLUZIONISTICA in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 (docente da definire)
( syllabus)
• Symbiotic interactions (phoresy, commensalism, exploitation, mutualism). Parasitism: definitions. Exploitation and trophic interactions: distinct adaptive strategies (predator/prey, parasitoid/prey, micropredators, parasite/host). Kinds of parasites: endo- and ecto-parasites, micro- and macro-parasites, obligate and facultative parasites, hyperparasites. Kinds of hosts: definitive and intermediate hosts, vectors, paratenic (transport) hosts, reservoire hosts. Mechanisms of invasion, evasion, and survival, transmission strategies. Protozoa and main Metazoan parasites: Platyhelminthes, Nematoda, Acanthocephala, Pentastomida, Arthropoda; pararitism in other metazoan groups.• Evolutionary parasitology. Origins of parasitism and transition to parasitism from a free-living ancestral life-style; resistance against the host's defense mechanisms and evolution of host specificity; complex life-cycles shaped by historical events and selective pressures; hosts as part of parasite environment and as a source of selective pressure. Host manipulation by parasites (e.g. behavioral alterations in parasitized hosts). Development of resistance, tolerance and life-history parameters in host species. Host-parasite coevolution: an evolutionary arms race and the “Red-queen” hypothesis. • Evolutionary ecology of parasites. How complex life cycles have influenced the ecology of parasites. Evolutionary ecology of parasites at different hierarchical levels: individual, population, and community ecology. Parasitism and community structure in natural ecosystems. Parasites as ubiquitous components of ecosystems. Parasite’s influence on survival and reproduction of individual hosts, on the dynamics of host populations, and on the structure of entire communities. (A) parasites alter the flow of energy through a food web by converting host tissue into parasite tissue and (B) parasite-increased trophic transmission alters predator-prey dynamics by making infected prey easier to capture.• Cladogenesis of parasitic taxa and co-speciation of parasite and host species. Phylogeny and ecology of host and parasite: how phylogeny may provide insights into the evolution of host and parasite associations, and how ecological data may provide insights into phylogenetic relationships. Causes of diversity in parasite life-history traits: role of selective pressure from hosts and physical environments, and role of phylogenetic constraints• The biogeography of the host-parasite interaction.
( reference books)
Reference Texts and Atlas- Parasitism: The Ecology and Evolution of Intimate Interactions, Claude Combes, 2004, University of Chicago Press (ISBN: 9780226114460)- Evolutionary Evolutionary Ecology of Parasites, (Second Edition), Robert Poulin, 2006, Princeton University Press (ISBN: 9780691120850)- Parasitism: The Diversity and Ecology of Animal Parasites, Albert O. Bush, Jacqueline C. Fernández, Gerald W. Esch, J. Richard Seed, 2001, Cambridge University Press (ISBN-13: 978-0521664479)- Atlante di parassitologia, Frank Werner; Lieder Johannes, 2002, Franco Muzzio Editore (collana Scienze naturali), 3° edizione (ISBN: 978887413029)- Manuale di parassitologia veterinaria, Genchi Marco; Traldi Giorgio; Genchi Claudio, 2010, Editore CEA (ISBN-10: 8808183483)
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22402257 -
GENERAL AND APPLIED ANIMAL VIROLOGY
(objectives)
OBJECTIVS: TO ACQUIRE A SOLID FOUNDATION IN ANIMAL VIROLOGY AND THEIR APPLICATION.
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22402257-2 -
MODULO 2
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AFFABRIS ELISABETTA
( syllabus)
Module 2. It will be introduced applied virology and specific examples will be provided (i.e., vaccine development, viral vectors and oncolytic viruses). Students will be able to apply the acquired knowledge to understand in-depth texts and experimental data related to the discipline.
( reference books)
WHERE TO STUDY:Adopted text book:- Leonard Norkin – Virology: Molecular Biology and Pathogenesis - ASM (American Society for Microbiology) Press+- Fields virology, Vth edition, 2007- D.M.Knipe and P.M.Howley editors-in-chief -Lippincot Williams & Wilkins publishers, cap.16 Viral vectors and their applications (to study adenoviral, adeno-associated, retroviral and lentiviral vectors + oncolitic adenoviruses)- Stéphanie Durand and Andrea Cimarelli - The Inside Out of Lentiviral Vectors - Viruses 2011, 3, 132-159.It is available a CD with supplementary materials at the box office of “segreteria didattica biologia“
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22402257-1 -
MODULO 1
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AFFABRIS ELISABETTA
( syllabus)
Module 1:The course describes and compares the replication cycles of different animal viruses that infect vertebrate hosts to gain insight into: origin of viruses, structure, evolution, virus-cell interactions, host defense mechanisms and strategies of viral immunoevasion, methods of detection, identification and titration, antiviral drugs and profilaxis of viral infections. In particular, it will be described viruses of the following viral families: picornaviridae, ortomixoviridae, paramixoviridae, rabdoviridae, retroviridae, hepadnaviridae, flaviviridae, parvoviridae, poliomaviridae, papillomaviridae, adenoviridae, herpesviridae, poxviridae. Students will be able to apply the acquired knowledge to understand in-depth texts and experimental data related to the discipline.
( reference books)
WHERE TO STUDY:Adopted text book:- Leonard Norkin – Virology: Molecular Biology and Pathogenesis - ASM (American Society for Microbiology) Press+- Fields virology, Vth edition, 2007- D.M.Knipe and P.M.Howley editors-in-chief -Lippincot Williams & Wilkins publishers, cap.16 Viral vectors and their applications (to study adenoviral, adeno-associated, retroviral and lentiviral vectors + oncolitic adenoviruses)- Stéphanie Durand and Andrea Cimarelli - The Inside Out of Lentiviral Vectors - Viruses 2011, 3, 132-159.It is available a CD with supplementary materials at the box office of “segreteria didattica biologia“
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BIO/19
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20402024 -
BIOCHEMICAL PHYSICS
(objectives)
THE COURSE AIMS TO PROVIDE THE STUDENT WITH BASIC KNOWLEDGE ON THERMODYNAMICS AND KINETICS OF BIOLOGICAL PROCESSES, PARTICULARLY IN RELATIONSHIP WITH THE EXPERIMENTAL ACTIVITY IN THE LABORATORY.
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ANTONINI GIOVANNI
( syllabus)
Cultural competences (Knowledge of :) The Course aims to provide students with basic knowledge relating to thermodynamics and the kinetics of biological processes, particularly in relation to experimental activities in the laboratory.
Methodological skills (Know How to:) acquire and use experimental data relating to: to the study of interactions between proteins and ligands, enzyme kinetics and kinetic of binding
Program:
1) Study of the interaction between receptors and ligands: methods at equilibrium and transient kinetics:
a) At equilibrium (thermodynamic parameters: Kd: dissociation constant at equilibrium, cooperativity, number of binding sites)
b) Rapid kinetics (kinetic parameters: k: velocity constants)
2) Study of enzymatic activity: steady state kinetics
a) In Steady State (when [ES] is almost constant during experimental observation)
b) In the presence of inhibitors
3) Time-resolved optical spectroscopy and complex kinetics
( reference books)
Recommended textbooks:
M. C. Bonaccorsi di Patti et al. Metodologie Biochimiche - Casa Editrice Ambrosiana
Ninfa/Ballou Metodologie di base per la Biochimica e la Biotecnologia - ed. Zanichelli
Reed et al. Metodologie di Base per le Scienze Biomolecolari- ed. Zanichelli
P. Silvestroni, Fondamenti di chimica - Casa Editrice Ambrosiana
D.M. Etter Introduction to MATLAB 7– Pearson Education, Inc.
Software to use
EXCEL (Office) or CALC (Open Office) * (for linear methods)
MATLAB (Mathworks) or OCTAVE (GNU Octave) * (for spectral analysis and non-linear methods)
GEPASI (P. Mendes et al.) * Or COPASI (Copasi dev. Group) * (for complex reactions)
(*) indicates free software
Lecture notes and calculation exercises will be provided
The professor receives every day from
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BIO/11
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20402025 -
Bioindication and Environmental Monitoring
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Derived from
20402025 BIOINDICAZIONE E MONITORAGGIO AMBIENTALE in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 (docente da definire)
( syllabus)
Bioindication: basic concepts. Main ecological characteristics of a bioindicator. Two ways of bioindicate: react and accumulate. The homeostasis of the bioindicators. Times and ecological relevance of the bioindicator responses to environmental changes. Meaning of stress and stressor.
Bioindication at different levels of biological organization. Integrity and functionality of the ecosystem. Check of the plant and animal communities status and evaluation of the environmental quality. Two types of ecosystem approach: the theories of the Top-down and Buttom-Up.
Bioindication and environmental monitoring. Bioindication in aquatic, terrestrial and aerial environmental. Main examples of application of the bioindication procedures. Assessment of the environmental quality through ecological and biotic indices. Experimental and standard techniques for the biomonitoring. The Bioindication in Italy. Main European and national directives. National and international institutional bodies for the environmental monitoring.
( reference books)
Pdfs of the lessons performed during the course and the book: Bioindicatori ambientali, 1998, edited by F. Sartori, Graphic Arts Juri Iodice, Sannazzaro (PV).
The teacher receives Mon, Wed, Fri from 9.00 to 10.00 by appointment via email: simona.ceschin@uniroma3.it
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BIO/02
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20402506 -
MOLECULAR BASIS OF PLANT-ENVIRONMENT INTERACTION
(objectives)
TO INCREASE KNOWLEDGE CONCERNING FUNDAMENTAL PROCESSES UNDERLYING PLANT ACCLIMATION TO DIFFERENT ENVIRONMENTAL STRESSES, USEFUL IN DEVELOPING NEW STRATEGIES FOR IMPROVING CROP PRODUCTIVITY UNDER CHANGING ENVIRONMENTAL CONDITIONS IN THE CONTEXT OF SUSTAINABLE AGRICULTURE. BASIC KNOWLEDGE WILL BE PROVIDED ON PLANT EMPLOYMENT IN PHARMACOLOGICAL, NUTRACEUTICAL AND ENVIRONMENTAL FIELD.
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20402508 -
NATURAL PRODUCTS AND ENVIRONMENTAL CHEMISTRY
(objectives)
THE COURSE AIMS AT GIVING:
1) A GENERAL KNOWLEDGE OF THE BIOSYNTHETIC PATHWAYS OF SECONDARY METABOLISM;
2) INFORMATION ABOUT THE MAIN NATURAL PRODUCTS DERIVED FROM MICROORGANISM, PLANTS AND ANIMALS AND THEIR ROLE IN NATURAL ENVIRONMENT;
3) KNOWLEDGE ON THE STRUCTURE/BIOLOGICAL ACTIVITY RELATIONSHIP OF THE MAIN SECONDARY METABOLITES USED IN PHARMACEUTICAL AND HEALTHCARE INDUSTRY.
4) ATTAINMENT OF THE BASIC EDUCATIONAL BACKGROUND NECESSARY TO UNDERSTAND THE CHEMICAL EQUILIBRIA THAT REGULATE THE ORIGINS, THE TRANSPORT, THE TRANSFORMATIONS AND THE EFFECTS OF THE ENVIRONMENTAL CHEMICAL SPECIES, EITHER OF NATURAL OR HUMAN ORIGIN.
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Derived from
20402508 CHIMICA DELLE SOSTANZE NATURALI E DELL'AMBIENTE in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 N0 TOFANI DANIELA
( syllabus)
INTRODUCTION TO NATURAL PRODUCTS CHEMISTRY. MAIN FEATURES OF SECONDARY METABOLISM.
ACETATE PATHWAY. PROSTAGLANDINS, AROMATIC POLYKETIDES, ANTHRAQUINONES, CANNABINOIDS, AFLATOXINS.
SHIKIMATE PATHWAY. SHIKIMIC ACID BIOSYNTHESIS. CINNAMIC ACIDS. LIGNINES. PHENYLPROPANOIDS. BENZOIC ACIDS. COUMARINS. FLAVONOIDS. TANNINS. ISOFLAVONES. TERPENOID QUINONES.
MEVALONATE PATHWAY. MEVALONIC ACID BIOGENESIS. BIOSYNTHESIS OF DIFFERENT CLASSES OF TERPENES. IRIDOIDS. GIBBERELLINS. HORMONES. ANIMAL AND HUMAN STEROIDS. PHYTOSTEROLS.
ALKALOIDS: DEFINITION AND NOMENCLATURE. BIOSYNTHESIS AND BIOLOGICAL ACTIVITY OF THE MAIN CLASSES OF NATURAL ALKALOIDS: COCAINE, NICOTINE, CURARE, MORPHINE, LOGANIN, LYSERGIC ACID, CONIINE.
CARBOHYDRATES: GENERALITIES. CYANOGENIC GLYCOSIDES. STREPTOMYCINS.
PEPTIDIC SECONDARY METABOLITES. INTERFERONS. OPIOID PEPTIDES. PEPTIDE TOXINS: RICIN AND BOTULIN. PENICILLINS.
INTRODUCTION TO ENVIRONMENTAL CHEMISTRY. THE SPHERES IN WHICH THE EARTH IS DIVIDED.
THE ATMOSPHERE: OZONE LAYER FORMATION AND DEPLETION; CFCS AND HALONS. OXIDANT AND POLLUTANTS SPECIES. THE GREENHOUSE EFFECT. THE KYOTO’S PROTOCOL.
THE HYDROSPHERE: PHYSICAL AND CHEMICAL PROPERTIES OF WATER AND WATER BODIES. TIC, TOC, TC. EASY TO OXIDIZE ORGANIC POLLUTANTS (COD, BOD5) AND PERSISTENT ORGANIC POLLUTANTS (POP). SHORT AND LONG TERM TOXICITY (LD50 AND LOD50). NOEL AND ADI.
BIOACCUMULATION AND BIO-MAGNIFICATION. METABOLISM OF A FEW PESTICIDES.
( reference books)
P.M. DEWICK : MEDICINAL NATURAL PRODUCTS. A BIOSYNTHETIC APPROACH. THIRD EDITION. WILEY..
C. BAIRD, M. CANN “ENVIRONMENTAL CHEMISTRY”, FIFTH EDITION.
SLIDES OF THE LESSONS AND ADDITIONAL MATERIAL (PW PROTECTED) ARE AVAILABLE ON LINE AT THE ADDRESS: HTTP://HOST.UNIROMA3.IT/CENTRI/CISDIC/INDEX.HTM
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20402509 -
ECOLOGY AND MANAGEMENT OF COASTAL ECOSYSTEMS
(objectives)
MAJOR GOALS OF THIS COURSE ARE: TO ACQUIRE AN APPROPRIATE KNOWLEDGE OF THE BIODIVERSITY AND OF GENERAL PRINCIPLES OF THE ECOLOGY OF COASTAL ECOSYSTEMS AND THEIR RELATIONSHIP WITH OTHER ECOLOGICAL BRANCHES. OTHER GOAL OF THIS COURSE IS THE GROWTH OF A THOROUGH INTEREST TO ECOLOGICAL PROBLEMS DISCUSSING THE RELATIONSHIP BETWEEN MAN AND NATURE FOCUSING IN THE COASTAL ENVIRONMENT. THE COURSE IS ALSO INTENDED TO DEVELOP BASIC INSIGHTS FOR THE ACQUISITION, ORGANIZATION AND INTERPRETATION OF ECOLOGICAL DATA RECORDED IN COASTAL ECOSYSTEMS.
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20402509-1 -
MODULO 1
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3
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BIO/03
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20402509-2 -
MODULO 2
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1
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BIO/03
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10
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20402509-3 -
MODULO 3
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2
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BIO/05
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16
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20402511 -
LABORATORY OF ELECTRON AND ION BEAM MICROSCOPY APPLIED TO BIOLOGICAL SYSTEMS
(objectives)
THE COURSE AIMS TO PROVIDE THE STUDENT WITH BASIC KNOWLEDGE AND TECHNICAL SKILLS IN ORDER TO APPROACH THE STUDY OF BIOLOGICAL SPECIMENS BY ULTRASTRUCTURAL MORFOLOGICAL METHODOLOGIES.
MAIN OBJECTIVES INCLUDE LEARNING AND APPLYING:1) BASIC PRINCIPLES OF ELECTRON MICROSCOPY; 2) METHODOLOGIES OF SAMPLE PREPARATION (PROKARYOTES AND EUKARYOTES) FOR ULTRASTRUCTURAL ANALYSIS; 3) USAGE OF DEVICES FOR ULTRASTRUCTURAL INVESTIGATION (SCNANING, TRANSMISSION AND FOCUSING ION BEAM MICROSCOPY); 3) SOFTWARE FOR MICROSCOPIC IMAGE CAPTURING AND PROCESSING 4) QUALITATIVE INTERPRETATION AND QUANTITATIVE ANALYSIS OF ULTRASTRUCTURAL DATA.
THE STUDENT WILL BE ABLE TO AUTONOMOUSLY CHOOSE AND ADJUST EXPERIMENTAL PROTOCOLS, SUITED TO DIFFERENT SAMPLE TYPES AND TO THE OBJECTIVE OF THE STUDY. KNOWLEDGE ACQUIRED DURING THE COURSE WILL ALLOW THE STUDENT TO CRITICALLY ANALYZE MORPHOLOGICAL RESULTS IN A FUNCTIONAL CONTEXT.
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20402511-1 -
MODULO 1
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3
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BIO/05
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20402511-2 -
MODULO 2
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3
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BIO/06
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24
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20402512 -
METHODS AND TECHNIQUES IN VEGETATION ECOLOGY
(objectives)
MAJOR GOALS OF THIS COURSE ARE THE ACQUISITION OF KNOWLEDGE ON THE MAIN METHODS AND TECHNIQUES FOR THE STUDY OF VEGETATION:
- ACQUIRE THE MASTERY OF THE STUDY METHODS OF VEGETATION;
- INCREASE THE ABILITY TO INTERPRETING THE NATURAL AND ARTIFICIAL PHENOMENA WITH SPECIAL ATTENTION TO THE MECHANISMS OF TRANSFORMATION OF PLANT LANDSCAPES;
- DEVELOP THE CAPACITY TO APPLICATION OF MOST APPROPRIATE METHODS FOR MONITORING OF THE PLANT COMMUNITIES FOR CONSERVATION AND MANAGEMENT PURPOSES;
- INCREASE THE POSSIBILITIES OF INTERPRETATION OF EXPERIMENTAL DATA AND UNDERSTANDING OF SCIENTIFIC ARTICLES IN THE FIELDS OF PLANT ECOLOGY, GEOBOTANY AND APPLIED ECOLOGY.
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20402512-1 -
MODULO 1
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Derived from
20402512 METODI E TECNICHE IN ECOLOGIA DELLA VEGETAZIONE in BIODIVERSITA' E GESTIONE DEGLI ECOSISTEMI (DM 270) LM-6 (docente da definire)
( syllabus)
DEFINITION AND PROPERTIES OF PLANT COMMUNITIES. DISCRETE AND CONCRETE COMMUNITIES. ZONES AND BANDS OF VEGETATION. ZONALITY, AZONALITY AND EXTRAZONALITY. VEGETATION DYNAMICS AND POTENTIAL NATURAL VEGETATION. GROWTH FORMS AND PLANT TRAITS. ANALYSES OF THE FUNCTIONAL DIVERSITY AND GRIME’S STRATEGIES (C-S-R). DIVERSITY ANALYSES: GENERAL CONCEPT, ALGORITHMS CALCULATION, RAREFACTION CURVE, ABUNDANCE/DOMINANCE RANK, RE’NY CURVES. SAMPLING METHODS OF THE PLANT COMMUNITIES (RANDOM AND SYSTEMATIC SAMPLING). SIZE AND DISTRIBUTION OF SAMPLES. ABUNDANCE MEASURES. ORIGIN AND DEVELOPMENT OF THE PHYTOSOCIOLOGY (SYN- AND GEOSYNPHYTOSOCIOLOGY). GENERAL CONCEPT OF THE VEGETATION MAPPING. VEGETATION AND HABITAT INTERPRETATION (EUNIS AND ALL. I OF THE 92/43/CEE DIRECTIVE). HABITATS MONITORING, EUROPEAN AND NATIONAL RED LISTS OF HABITAT. MULTITEMPORAL ANALYSIS, ANTHROPIC IMPACT AND EFFECT OF VEGETATION.
( reference books)
BRECKLE S.W., 2002. Walter’s Vegetation of the Earth.Springer. VAN DER MAAREL E. (Ed.), 2005. Vegetation Ecology. Blackwell Publishing.
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3
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BIO/03
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24
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ITA |
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20402512-2 -
MODULO 2
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1
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BIO/03
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-
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-
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10
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ITA |
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20402512-3 -
MODULO 3
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2
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BIO/03
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16
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-
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ITA |
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20402518 -
TOXICOLOGY
(objectives)
THE COURSE AIMS TO PROVIDE PRECISE INFORMATION ON THE TOXICODYNAMIC AND TOXICOKINETIC MECHANISMS THAT ARE BEHIND THE TOXIC EFFECTS PRODUCED BY DIFFERENT NATURAL AND SYNTHESISED XENOBIOTICS, AND ON THE PROCESS OF EVALUATION OF TOXICOLOGICAL RISKS.
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TREZZA VIVIANA
( syllabus)
GENERAL PRINCIPLES. AIMS AND FIELDS OF TOXICOLOGY. CLASSIFICATION OF TOXIC AGENTS. MECHANISMS OF MOLECULAR AND CELL TOXICITY. RISK EVALUATION. TOXICOKINETICS: ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF TOXIC AGENTS. ADVERSE DRUG REACTIONS, DRUG INTERACTIONS AND PRINCIPLES OF PHARMACOVIGILANCE. ANTIDOTES AND THEIR CLASSIFICATION. EXPERIMENTAL EVALUATION OF TOXIC EFFECTS IN IN VITRO AND IN VIVO MODELS AND DATA EXTRAPOLATION. SYSTEM AND ORGAN TOXICOLOGY. DEVELOPMENTAL AND FEEDING TOXICOLOGY. CLASSES OF TOXIC COMPOUNDS: METALS, PHYTODRUGS, NATURAL TOXINS. PSYCHOACTIVE AND DOPING DRUGS.
( reference books)
CASARETT & DOULL'S “ESSENTIALS OF TOXICOLOGY”, SECOND EDITION, MCGRAW HILL
Power-point files of the lessons will be provided
To get an appointment with the Professor, email to: viviana.trezza@uniroma3.it
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6
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BIO/14
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48
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20402519 -
APPLIED CELLULAR NEUROBIOLOGY
(objectives)
THE AIMS OF THIS COURSE ARE: TO GAIN KNOWLEDGE OF THE SPECIALIZED CELLULAR ARCHITECTURE OF GLIA AND NEURONS; TO DEEPEN THE KNOWLEDGE OF CELLULAR AND MOLECULAR MECHANISMS INVOLVED IN CELL COMMUNICATION, SPECIAL EMPHASIS WILL BE GIVEN TO NITRIC OXIDE-REGULATED PATHWAYS. IN THIS COURSE STUDENTS CAN USE STATE OF THE ART EQUIPMENT AND LEARN CURRENT TECHNIQUES EMPLOYED IN CELL BIOLOGY RESEARCH LABS. MOREOVER STUDENTS ARE ALLOWED TO CRITICALLY DISCUSS THE SCIENTIFIC LITERATURE IN THE FIELD OF CELL BIOLOGY.
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20402519-1 -
MODULO 1
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4
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BIO/06
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32
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ITA |
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20402519-2 -
MODULO 2
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2
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BIO/06
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-
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-
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20
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ITA |
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20402520 -
PLANT BIOTECHNOLOGY FOR THE GENETIC IMPROVEMENT OF FOOD CROPS
(objectives)
THIS COURSE WILL PROVIDE STUDENTS WITH AN IN-DEPTH KNOWLEDGE OF PLANT TRANSFORMATION TECHNIQUES AND PLANT BIOTECHNOLOGY APPLICATIONS WITHIN AGRICULTURE AND PRODUCTION OF NEW MOLECULES. THIS COURSE WILL ALSO GIVE EDUCATION ON EMERGING TECHNOLOGIES, SUCH AS TRANSCRIPTOMICS, PROTEOMICS, METABOLOMICS, AND WILL DESCRIBE THEIR IMPORTANCE IN PLANT BIOTECHNOLOGY RESEARCH. ANOTHER IMPORTANT AIM OF THE COURSE IS TO PREPARE STUDENTS TO CONDUCT LABORATORY WORK AND RESEARCH IN THE SECTORS OF PLANT BIOTECHNOLOGY AND FOOD INDUSTRY, AS WELL AS TO CRITICALLY ANALYZE THE SCIENTIFIC INFORMATION
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20402520-1 -
MODULO 1
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TAVLADORAKI PARASKEVI
( syllabus)
THREE ARE THE MAIN ARGUMENTS OF THE COURSE: GENE TRANSFER TECHNIQUES; APPLICATIONS OF PLANT BIOTECHNOLOGY; ANALYSIS OF RISKS AND BENEFITS OF PLANT GENETIC MANIPULATION.IN DETAIL, DURING THE COURSE THE FOLLOWING ARGUMENTS ARE DISCUSSED:TECHNIQUES FOR GENE TRANSFER INTO THE NUCLEAR AND CHLOROPLASTIC GENOME; TECHNIQUES FOR IN VITRO CULTURE OF PLANT CELLS; USE OF SELECTABLE GENE MARKERS AND REPORTER GENES; STRATEGIES TO REMOVE SELECTABLE GENE MARKERS FROM TRANSGENIC PLANTS; INDUCIBLE EXPRESSION OF TRANSGENES IN PLANTS; TRANSIENT EXPRESSION OF GENES IN PLANTS; GENE SILENCING IN PLANTS; ‘GENE TARGETING’ IN PLANTS; GENOME EDITINGIN IN PLANTS; PLANTS WITH IMPROVED NUTRITIONAL VALUE; PRODUCTION OF ANTIBODIES AND VACCINES IN TRANSGENIC PLANTS; BIOTECHNOLOGICAL STRATEGIES TO OBTAIN PLANTS RESISTANT TO HERBICIDES, PATHOGENS AND ENVIRONMENTAL STRESSES; PLANTS WITH INCREASED PHOTOSYNTHETIC RATE; BIOSAFETY AND BIOETHICAL ISSUES RELATED TO PLANT BIOTECHNOLOGY; EMERGING TECHNOLOGIES AND PLANT BIOTECHNOLOGY.
( reference books)
-Recommended textbooks:1. BIOCHEMISTRY AND MOLECULAR BIOLOGY OF PLANTS (2000) BUCHANAN B.B, GRUISSEM W., JONES R.L., AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MARYLAND.2. BIOLOGIA CELLULARE E BIOTECNOLOGIE VEGETALI (2011) COZZOLINO S., DI SANSEBASTIANO G.P., FORNI C., GENRE A., LANFRANCO L., MICCHELI A., PASQUA G., TRAINOTTI L., VALLETTA A.3. HANDBOOK OF PLANT BIOYECHNOLOGY (2004) CHRISTOU P., KLEE H., HOBOKEN, (N.J.), WILEY.4. PLANT BIOTECHNOLOGY AND TRANSGENIC PLANTS (2002) OKSMAN-CALDENTEY K.-M., BARZ W.H., NEW YORK, DEKER.-Scientific articles published in international journals (pdf files will be provided).-Lecture notes will be provided.
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4,5
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BIO/04
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36
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Related or supplementary learning activities
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ITA |
20402520-2 -
MODULO 2
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TAVLADORAKI PARASKEVI
( syllabus)
LABORATORY ACTIVITY: TRANSFORMATION OF ARABIDOPSIS PLANTS; ANALYSIS OF TRANSGENIC PLANTS BY PCR, RT-PCR, WESTERN BLOT AND ENZYME ACTIVITY ASSAYS; ANALYSIS OF REPORTER GENES IN TRANSGENIC PLANTS; ANALYSIS OF FOOD MATERIAL FOR THE PRESENCE OF GENETICALLY MODIFIED MATERIAL.
( reference books)
-Recommended textbooks:1. BIOCHEMISTRY AND MOLECULAR BIOLOGY OF PLANTS (2000) BUCHANAN B.B, GRUISSEM W., JONES R.L., AMERICAN SOCIETY OF PLANT PHYSIOLOGISTS, ROCKVILLE, MARYLAND.2. BIOLOGIA CELLULARE E BIOTECNOLOGIE VEGETALI (2011) COZZOLINO S., DI SANSEBASTIANO G.P., FORNI C., GENRE A., LANFRANCO L., MICCHELI A., PASQUA G., TRAINOTTI L., VALLETTA A.3. HANDBOOK OF PLANT BIOYECHNOLOGY (2004) CHRISTOU P., KLEE H., HOBOKEN, (N.J.), WILEY.4. PLANT BIOTECHNOLOGY AND TRANSGENIC PLANTS (2002) OKSMAN-CALDENTEY K.-M., BARZ W.H., NEW YORK, DEKER.-Scientific articles published in international journals (pdf files will be provided).-Lecture notes will be provided.
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1,5
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BIO/04
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-
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15
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20402521 -
MOLECULAR ENDOCRINOLOGY
(objectives)
ENDOCRINOLOGY IS USUALLY TAUGHT AT THE END OF STANDARD PHYSIOLOGY COURSES, BECAUSE THE ENDOCRINE SYSTEM REGULATES ALL THE OTHER ORGAN SYSTEMS. IN THIS RESPECT, LEARNING ABOUT ENDOCRINE SYSTEM HAS THE ADDED CHALLENGE OF INTEGRATING STUDENT KNOWLEDGE OF HORMONES AND THEIR ACTIONS WITH THE GENERAL FUNCTION OF A SPECIFIC ORGAN SYSTEM. THE MAIN OBJECTIVES OF THIS COURSE ARE TO ALLOW THE STUDENT TO GAIN A FOUNDATION OF KNOWLEDGE ABOUT THE ENDOCRINE SYSTEM AND INTEGRATIVE PHYSIOLOGY, TO BECOME REFINED IN THE CRITICAL ANALYSIS OF SCIENTIFIC PAPERS RELATED TO ENDOCRINE PHYSIOLOGY, TO DEVELOP PROBLEM SOLVING AND PUBLIC SPEAKING TECHNIQUES.
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20402522 -
DEVELOPMENTAL NEUROBIOLOGY
(objectives)
THE MAIN GOAL IS TO PROVIDE ADVANCED KNOWLEDGE IN DEVELOPMENTAL BIOLOGY, WITH SPECIAL REFERENCE TO THE NERVOUS SYSTEM. THE CELLULAR AND MOLECULAR MECHANISMS UNDERLYING NERVOUS TISSUE DIFFERENTIATION AND MORPHOGENESIS WILL BE ADDRESSED IN DIFFERENT IN VIVO MODELS. LIFE-LONG FUNCTIONAL IMPLICATIONS OF NEUROGENESIS AND PLASTICITY WILL BE EMPHASIZED. THE STUDENT WILL BE ABLE TO: 1) DESCRIBE DEVELOPMENTAL PROCESSES OF INVERTEBRATE AND VERTEBRATE NERVOUS SYSTEM; 2) RECOGNISE MOLECULAR PATHWAYS DIRECTING STEM CELLS TOWARDS NEURONAL/GLIAL CELL DIFFERENTIATION; 3) CORRELATE ONTOGENETIC ABNORMALITIES WITH SPECIFIC NEUROLOGICAL DISTURBANCES, INCLUDING INFANTILE DISEASES AND AGE-RELATED NEURODEGENERATION.
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20402522-1 -
MODULO 1
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MORENO SANDRA
( syllabus)
Main goal of the course is to provide advanced knowledge in developmental biology, with special reference to vertebrate nervous system. The cellular and molecular mechanisms underlying nervous tissue differentiation and morphogenesis will be addressed in different in vivo and in vitro models. Life-long functional implications of neurogenesis and plasticity will be emphasized. Upon completion of the course, the student will acquire: 1) Knowledge of neurodevelopmental processes of vertebrate nervous system; 2) Knowledge of the principal molecular pathways of neurogenesis; 3) Ability to correlate ontogenetic abnormalities with specific neurological disturbances, including infantile diseases and age-related neurodegeneration;4) Competence in recognizing mammalian neurodevelopmental stages, by observation of synthetic models or histological slides;5) Competence in utilizing morphological techniques (immunohistochemistry, immunofluorescence, electron microscopy), to characterize mammalian brain at different stages.Program of lectures and lab sessionsOverview of developmental processes of pluricellular organisms. Germ cell layers. Ectodermal derivation of neural tissue in invertebrates e vertebrates. Specification of neuroectoderm and neurulation process in vertebrates. Primary neurulation: cellular e molecular mechanisms of neural plate, folds, furrow, and tube formation. Secondary neurulation. Neural tube defects in mammals: genetic and environmental causes of anencephaly and spina bifida. Morphogenesis and differentiation of the encephalon and spinal cord. Role of cell death in the morphogenesis of the central nervous system: apoptotic and autophagic pathways. Neural crest: specification and regionalization. Cell migration and differentiation of cephalic, cardiac, trunk, vagal e sacral neural crest. Multipotency e plasticity of neural crest cells. Layering of cortical structures in the cerebrum and cerebellum. Congenital diseseases associated with defects to neuronal migration: the case of peroxisomal disorders. Neural stem cells: neuronal and glial differentiation. Adult neurogenesis in mammals: the subventricular and subgranular zones. The concept of stem cell niche. Regulatory pathways of the neurogenic niche. Neurogenesis and neurodegeneration in the senescent brain. Age-related neurodegenerative diseases: common and specific features. Protein aggregates, role of apoptotic and autophagic pathways, and stem cell-based therapies against neurodegeneration.
( reference books)
GILBERT: "DEVELOPMENTAL BIOLOGY", SINAUER ASSOCIATES, INC.SANES ET AL.: "DEVELOPMENT OF THE NERVOUS SYSTEM", ELSEVIER INC.
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5
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BIO/06
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40
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Related or supplementary learning activities
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ITA |
20402522-2 -
MODULO 2
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MORENO SANDRA
( syllabus)
Main goal of the course is to provide advanced knowledge in developmental biology, with special reference to vertebrate nervous system. The cellular and molecular mechanisms underlying nervous tissue differentiation and morphogenesis will be addressed in different in vivo and in vitro models. Life-long functional implications of neurogenesis and plasticity will be emphasized. Upon completion of the course, the student will acquire: 1) Knowledge of neurodevelopmental processes of vertebrate nervous system; 2) Knowledge of the principal molecular pathways of neurogenesis; 3) Ability to correlate ontogenetic abnormalities with specific neurological disturbances, including infantile diseases and age-related neurodegeneration;4) Competence in recognizing mammalian neurodevelopmental stages, by observation of synthetic models or histological slides;5) Competence in utilizing morphological techniques (immunohistochemistry, immunofluorescence, electron microscopy), to characterize mammalian brain at different stages.Program of lectures and lab sessionsOverview of developmental processes of pluricellular organisms. Germ cell layers. Ectodermal derivation of neural tissue in invertebrates e vertebrates. Specification of neuroectoderm and neurulation process in vertebrates. Primary neurulation: cellular e molecular mechanisms of neural plate, folds, furrow, and tube formation. Secondary neurulation. Neural tube defects in mammals: genetic and environmental causes of anencephaly and spina bifida. Morphogenesis and differentiation of the encephalon and spinal cord. Role of cell death in the morphogenesis of the central nervous system: apoptotic and autophagic pathways. Neural crest: specification and regionalization. Cell migration and differentiation of cephalic, cardiac, trunk, vagal e sacral neural crest. Multipotency e plasticity of neural crest cells. Layering of cortical structures in the cerebrum and cerebellum. Congenital diseseases associated with defects to neuronal migration: the case of peroxisomal disorders. Neural stem cells: neuronal and glial differentiation. Adult neurogenesis in mammals: the subventricular and subgranular zones. The concept of stem cell niche. Regulatory pathways of the neurogenic niche. Neurogenesis and neurodegeneration in the senescent brain. Age-related neurodegenerative diseases: common and specific features. Protein aggregates, role of apoptotic and autophagic pathways, and stem cell-based therapies against neurodegeneration.
( reference books)
GILBERT: "DEVELOPMENTAL BIOLOGY", SINAUER ASSOCIATES, INC.SANES ET AL.: "DEVELOPMENT OF THE NERVOUS SYSTEM", ELSEVIER INC.
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1
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BIO/06
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-
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-
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10
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Related or supplementary learning activities
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ITA |
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20402523 -
MOLECULAR AND CELLULAR PHYSIOLOGY
(objectives)
ON THE BASIS OF THE MOST RECENT SCIENTIFIC LITERATURE, THE COURSE IS AIMED TO ALLOW THE STUDENTS TO UNDERSTAND SOME ASPECTS OF THE REGULATION OF CELLULAR FUNCTIONS
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20402523-1 -
MODULO 1
-
ACCONCIA FILIPPO
( syllabus)
MECHANISMS OF CELL FUNCTION REGULATION: PHOSPHORYLATION- AND UBIQUITINATION-BASED INTRACELLULAR SIGNALLING; TYROSIN-KINASES AND NUCLEAR RECEPTORS AS MODULATORS OF CELLULAR FUNCTIONS (2,5 CFU).REGULATION OF THE MOLECULAR MECHANISMS OF ENDOCYTOSIS, CELL CYCLE, GENE TRANSCRIPTION, CELL MOTILITY AND CELL MIGRATION (2,5 CFU).REGULATION OF SOME ASPECTS OF THE LIPID AND SUGAR METABOLISM WITH PARTICOLAR FOCUS ON SOME SPECIFIC REGULATORY ENZYMES (AMPK, CHOLESTEROL SENSORS) (1 CFU).
( reference books)
NO REFERENCE BOOK. MATERIAL IS SUPPLIED DURING LECTURES BY THE PROFESSOR.
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5
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BIO/09
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40
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-
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Related or supplementary learning activities
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ITA |
20402523-2 -
MODULO 2
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ACCONCIA FILIPPO
( syllabus)
MECHANISMS OF CELL FUNCTION REGULATION: PHOSPHORYLATION- AND UBIQUITINATION-BASED INTRACELLULAR SIGNALLING; TYROSIN-KINASES AND NUCLEAR RECEPTORS AS MODULATORS OF CELLULAR FUNCTIONS (2,5 CFU).REGULATION OF THE MOLECULAR MECHANISMS OF ENDOCYTOSIS, CELL CYCLE, GENE TRANSCRIPTION, CELL MOTILITY AND CELL MIGRATION (2,5 CFU).REGULATION OF SOME ASPECTS OF THE LIPID AND SUGAR METABOLISM WITH PARTICOLAR FOCUS ON SOME SPECIFIC REGULATORY ENZYMES (AMPK, CHOLESTEROL SENSORS) (1 CFU).
( reference books)
NO REFERENCE BOOK. MATERIAL IS SUPPLIED DURING LECTURES BY THE PROFESSOR.
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1
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BIO/09
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-
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-
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10
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Related or supplementary learning activities
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ITA |
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Università Roma Tre