Università Roma Tre

General principles
Areas of study and specialization in toxicology; Classification of toxic agents; Definition of unwanted effects induced by a xenobiotic; Significance of local and systemic toxicity; Interaction between multiple xenobiotics and toxic responses; Selectivity of the toxic effect; Exposure characteristics (dose, duration, frequency); dose-effect relationship; therapeutic index; safety margin; NOAEL, LOAEL, DL50; Toxicological studies; Mechanisms of interference of xenobiotics with physiological processes; Concepts and mechanisms underlying the processes of absorption, biotransformation, distribution and excretion of a xenobiotic; Risk and Toxicity: meaning and consequences; Evaluation and extrapolation of experimental toxicological data to humans.
Organ and system toxicology
Liver, renal, cardiovascular, skin and CNS toxicity.
Developmental toxicology
Principles of developmental toxicology. Critical periods of susceptibility and risk assessment. Pathogenetic mechanisms of developmental toxicity. Toxicokinetics in pregnancy. Toxicity to the mother and effects on embryo-foetal development (ethanol, methylmercury, lead, etc.).
Food toxicology
Bacterial toxins; mycotoxins; pesticides; additives; animal and plant toxins. Quality control issues (contamination, adulteration, adulteration)
Substances of abuse
Toxicity, abuse, dependence, withdrawal from: stimulants, depressants, psychedelic-hallucinogens. Smart drugs
Toxic effects of pesticides, metals, solvents
Clinical toxicology
General antidotism. Poisonings from: acids, alkalis, carbon monoxide, sulfur dioxide, nitrogen oxides, ozone, paracetamol, amphetamines, anticholinergics, cyanide, digitalis, ethanol, hydrocarbons, insecticides (chlorinated, organophosphorus and carbamate, botanical), herbicides, polychlorinated biphenyls, iron, mercury, opiates, phenothiazines, salicylates, hypnotics and sedatives, tricyclic antidepressants. Toxicity of over-the-counter products.
Farmacovigilanza

Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition
Power-point files of the lessons will be provided

To get an appointment with the Professor, email to: viviana.trezza@uniroma3.it