Università Roma Tre

Properties and Overview of Immune Responses: innate and adaptive immunity, types of adaptive immune responses, cardinal features of adaptive immune responses, cellular components of the adaptive immune system, cytokines, soluble inflammatory mediators; The innate immune response; The adaptive immune response. Cells and Tissues of the Immune System: Phagocytes, Mast Cells, Basophils, Eosinophils, Antigen-Presenting Cells, Lymphocytes; Basic notions of anatomy and functions of lymphoid tissue. Leukocyte Circulation and Migration into Tissues: Adhesion molecules on leukocytes and endothelial cells involved in leukocyte recruitment; Chemokines and chemokine receptors; Migration of neutrophils and monocytes to sites of infection or tissue injury.
Innate immunity and inflammation: Recognition of microbes and damaged self by the innate immune system; Cellular components of the innate immune system; Soluble recognition and effector molecules of innate immunity; the inflammatory response, The complement system and the pathological effects of its activation.
Antibodies and Antigens: Antibody structure, synthesis, assembly, and expression of ig molecules, structure-function relationships in antibody molecules; Features of biologic antigens, structural and chemical basis of antigen binding; Monoclonal antibodies and their use for diagnostic and therapeutic purposes. Major Histocompatibility Complex Molecules and Antigen Presentation to T Lymphocytes: Properties of antigens recognized by t lymphocytes; The major histocompatibility complex (MHC), processing of protein antigens.
Lymphocyte Development and Antigen Receptor Gene Rearrangement: B and T lymphocytes development; Rearrangement of antigen receptor genes in B and T lymphocytes, Germline organization of Ig and TCR genes, V(D)J Recombination. Activation of T Lymphocytes: Signals for T lymphocyte activation, functional responses of T lymphocytes. Differentiation and Functions Cell-mediated immunity: Subsets of CD4+ effector T cells, effector functions of CD8+ cytotoxic T lymphocytes; Functions of other T cell subsets. B Cell Activation and Antibody Production: Antigen recognition and antigen-induced B cell activation, helper T cell–dependent antibody responses to protein antigens, antibody responses to T-independent antigens.
Effector Mechanisms of Humoral Immunity: Neutralization of microbes and microbial toxins; antibody-mediated opsonization and phagocytosis, antibody-dependent cell-mediated cytotoxicity, antibody-mediated clearance of helminths; Specialized immunity at epithelial barriers and in immune privileged tissues.
Immunologic Tolerance and Autoimmunity: T lymphocyte tolerance, B lymphocyte tolerance; Mechanisms of autoimmunity, genetic basis of autoimmunity, role of infections in autoimmunity. Immunity to Microbes: Overview of immune responses to microbes: immunity to extracellular bacteria, immunity to intracellular bacteria, immunity to fungi, viruses and parasites; Adverse reactions: septic shock, tissue and organ damage mediated by antibodies or immune complexes, organ damage by cell-mediated immunity.
Immune responses to tumors, evasion of immune responses by tumors, immunotherapy for tumors.
Hypersensitivity Disorders: Mechanisms and classification of hypersensitivity reactions, diseases caused by antibodies, Immediate hypersensitivitycaused by IgE; diseases caused by T lymphocytes; selected immunologic diseases: pathogenesis and therapeutic strategies: allergy, anaphylaxis, angioedema, transfusion reaction, fetal erythroblastosis, rheumatic fever, Graves' disease, serum sickness, poststreptococcal glomerulonephritis. Congenital and Acquired Immunodeficiencies.

Abbas Abul K.; Lichtman Andrew H.; Pillai Shiv.: Immunologia cellulare e molecolare. Edizione 2015 Edra-Masson ISBN 10: 8821439623 ISBN 13: 9788821439629

Abbas Abul K.; Lichtman Andrew H.; Pillai Shiv.: Le basi dell'immunologia. Fisiopatologia del sistema immunitario. Edizione 2015 Edra-Masson ISBN: 8821438562 / ISBN-13: 9788821438561