Università Roma Tre

The Course aims to provide the student with advanced knowledge and skills in molecular biology of neurodevelopment, with particular reference to the central nervous system of vertebrates.

The aim of the first module is to provide the student with general knowledge about the cellular processes that lead, in the course of early and late embryogenesis, to the formation of the central nervous system from the neural tube. Advanced concepts on morphogenetic processes ensuring the achievement of the general cytoarchitecture of telecephalon, diencephalon, mesencephalon, metencephalon, myelencephalon and spinal cord will be provided. In particular, the student will acquire knowledge and skills on neuronal migration processes (under normal and pathological conditions) that lead to the layering of the cerebral cortex, spinal cord, and cerebellum. Advanced knowledge and expertise will also be provided on the cellular processes underlying adult neurogenesis and neurodegeneration, focusing on the role of apoptosis and autophagy. The student, through an interactive teaching will acquire skills in the study of pathological conditions, such as the most common neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Huntington's chorea).

The aim of the second module is to provide the student with general knowledge regarding the gene expression underlying the differentiation and morphogenesis of the nervous tissue. These molecular mechanisms will be addressed in different study models. It will be highlighted how neurogenesis and plasticity have profound functional implications in the nervous system throughout the life of the individual. The student, by means an interactive teaching, will acquire skills on new biomolecular technologies to study the development and functionality of the nervous system under physiological and pathological conditions.