Università Roma Tre

BASIC THERMODYNAMICS CONCEPTS, FREE ENERGY, ENTHALPY, ENTROPY. AMINO ACIDS PROPERTIES: STRUCTURE, HYDROPHOBICITY, INTERACTIONS. PROTEIN STRUCTURE: PRIMARY STRUCTURE, SECONDARY STRUCTURE SUPERSECONDARY STRUCTURES (BETA-ALPHA-BETA, BETA BARREL, JELLY ROLL, T-KNOT, WW DOMAIN STRUCTURAL MOTIFS). PROTEINS STABILITY: COVALENT INTERACTIONS, NON COVALENT INTERACTIONS. STRUCTURE-FUNCTION RELATIONSHIPS: ION TRANSPORT (BACTERIORHODOPSINS, RHODOPSINS, POTASSIUM CHANNEL, AQUAPORINS), REDOX REACTIONS (SUPEROXIDE DISMUTASE, AMINO OXIDASES, PHOTOSISTEMS). MOLECULAR RECOGNITION: THEORETICAL PRINCIPLES (ELECTROSTATIC INTERACTIONS, HYDROPHOBIC INTERACTIONS, ENTROPIC CONTRIBUTIONS), PROTEIN TOXINS, PROTEASES, DNA-BINDING PROTEINS. PROTEIN ENGINEERING: METHODS AND STRATEGIES, STRUCTURE AND FUNCTION ENGINEERING. DETERMINATION OF PROTEIN STRUCTURE: NMR, X-RAY DIFFRACTION. BIOINFORMATICS AND COMPUTATIONAL CHEMISTRY: DATABASES, PROTEIN SEQUENCE ANALYSIS, MOLECULAR MODELLING, MOLECULAR DYNAMICS, ELECTROSTATICS.

BRANDEN C. & TOOZE J. INTRODUCTION TO PROTEIN STRUCTURE. GARLAND PUBLISHING, SECOND EDITION. PETSKO G.A. & RINGE D. PROTEIN STRUCTURE AND FUNCTION. NEW SCIENCE PRESS. WILLIAMSON M. HOW PROTEINS WORK. GARLAND PUBLISHING.

BASIC THERMODYNAMICS CONCEPTS, FREE ENERGY, ENTHALPY, ENTROPY. AMINO ACIDS PROPERTIES: STRUCTURE, HYDROPHOBICITY, INTERACTIONS. PROTEIN STRUCTURE: PRIMARY STRUCTURE, SECONDARY STRUCTURE SUPERSECONDARY STRUCTURES (BETA-ALPHA-BETA, BETA BARREL, JELLY ROLL, T-KNOT, WW DOMAIN STRUCTURAL MOTIFS). PROTEINS STABILITY: COVALENT INTERACTIONS, NON COVALENT INTERACTIONS. STRUCTURE-FUNCTION RELATIONSHIPS: ION TRANSPORT (BACTERIORHODOPSINS, RHODOPSINS, POTASSIUM CHANNEL, AQUAPORINS), REDOX REACTIONS (SUPEROXIDE DISMUTASE, AMINO OXIDASES, PHOTOSISTEMS). MOLECULAR RECOGNITION: THEORETICAL PRINCIPLES (ELECTROSTATIC INTERACTIONS, HYDROPHOBIC INTERACTIONS, ENTROPIC CONTRIBUTIONS), PROTEIN TOXINS, PROTEASES, DNA-BINDING PROTEINS. PROTEIN ENGINEERING: METHODS AND STRATEGIES, STRUCTURE AND FUNCTION ENGINEERING. DETERMINATION OF PROTEIN STRUCTURE: NMR, X-RAY DIFFRACTION. BIOINFORMATICS AND COMPUTATIONAL CHEMISTRY: DATABASES, PROTEIN SEQUENCE ANALYSIS, MOLECULAR MODELLING, MOLECULAR DYNAMICS, ELECTROSTATICS.

BRANDEN C. & TOOZE J. INTRODUCTION TO PROTEIN STRUCTURE. GARLAND PUBLISHING, SECOND EDITION. PETSKO G.A. & RINGE D. PROTEIN STRUCTURE AND FUNCTION. NEW SCIENCE PRESS. WILLIAMSON M. HOW PROTEINS WORK. GARLAND PUBLISHING.

STRUCTURE-FUNCTION RELATIONSHIPS OF MACROMOLECULAR MODELS: MYOGLOBIN, HEMOGLOBIN, TRYPSIN, CHIMOTRYPSIN, ALBUMIN, CYTOCHROMES, AND CYTOCHROME-OXIDASE.

RECEPTION: MONDAY, FROM 10 TO 11 AM.

MCKEE, BIOCHIMICA, MCGRAW - HILL
NELSON, COX, I PRINCIPI DI BIOCHIMICA DI LEHININGER, ZANICHELLI
VOET, VOET, PRATT, FONDAMENTI DI BIOCHIMICA, ZANICHELLI
STRYER, BIOCHIMICA, ZANICHELLI
RAWN, BIOCHIMICA MCGRAW-HILL
MORAN ET AL., BIOCHIMICA MCGRAW-HILL
GARRET, GRISHAM, BIOCHIMICA, ZANICHELLI