Università Roma Tre

INTRODUCTION TO NATURAL PRODUCTS CHEMISTRY. MAIN FEATURES OF SECONDARY METABOLISM.
ACETATE PATHWAY. PROSTAGLANDINS, AROMATIC POLYKETIDES, ANTHRAQUINONES, CANNABINOIDS, AFLATOXINS.
SHIKIMATE PATHWAY. SHIKIMIC ACID BIOSYNTHESIS. CINNAMIC ACIDS. LIGNINES. PHENYLPROPANOIDS. BENZOIC ACIDS. COUMARINS. FLAVONOIDS. TANNINS. ISOFLAVONES. TERPENOID QUINONES.
MEVALONATE PATHWAY. MEVALONIC ACID BIOGENESIS. BIOSYNTHESIS OF DIFFERENT CLASSES OF TERPENES. IRIDOIDS. GIBBERELLINS. HORMONES. ANIMAL AND HUMAN STEROIDS. PHYTOSTEROLS.
ALKALOIDS: DEFINITION AND NOMENCLATURE. BIOSYNTHESIS AND BIOLOGICAL ACTIVITY OF THE MAIN CLASSES OF NATURAL ALKALOIDS: COCAINE, NICOTINE, CURARE, MORPHINE, LOGANIN, LYSERGIC ACID, CONIINE.
CARBOHYDRATES: GENERALITIES. CYANOGENIC GLYCOSIDES. STREPTOMYCINS.
PEPTIDIC SECONDARY METABOLITES. INTERFERONS. OPIOID PEPTIDES. PEPTIDE TOXINS: RICIN AND BOTULIN. PENICILLINS.
INTRODUCTION TO ENVIRONMENTAL CHEMISTRY. THE SPHERES IN WHICH THE EARTH IS DIVIDED.
THE ATMOSPHERE: OZONE LAYER FORMATION AND DEPLETION; CFCS AND HALONS. OXIDANT AND POLLUTANTS SPECIES. THE GREENHOUSE EFFECT. THE KYOTO’S PROTOCOL.
THE HYDROSPHERE: PHYSICAL AND CHEMICAL PROPERTIES OF WATER AND WATER BODIES. TIC, TOC, TC. EASY TO OXIDIZE ORGANIC POLLUTANTS (COD, BOD5) AND PERSISTENT ORGANIC POLLUTANTS (POP). SHORT AND LONG TERM TOXICITY (LD50 AND LOD50). NOEL AND ADI.
BIOACCUMULATION AND BIO-MAGNIFICATION. METABOLISM OF A FEW PESTICIDES.

P.M. DEWICK : MEDICINAL NATURAL PRODUCTS. A BIOSYNTHETIC APPROACH. THIRD EDITION. WILEY..
C. BAIRD, M. CANN “ENVIRONMENTAL CHEMISTRY”, FIFTH EDITION.
SLIDES OF THE LESSONS AND ADDITIONAL MATERIAL (PW PROTECTED) ARE AVAILABLE ON LINE AT THE ADDRESS: HTTP://HOST.UNIROMA3.IT/CENTRI/CISDIC/INDEX.HTM