Università Roma Tre

GENERAL AETIOLOGY. CONCEPTS OF HEALTH, PATHOLOGICAL PROCESS AND DISEASE; AETIOLOGY, PATHOGENESIS, EVOLUTION, DISEASE COURSE, OUTCOME.

ENVIRONMENTAL DISEASES. DISEASES CAUSED BY PHYSICAL AND CHEMICAL AGENTS

INFECTIOUS DISEASES. DISEASES CAUSED BY BIOLOGICAL AGENTS. BACTERIAL ESOTOXINS AND ENDOTOXINS. NEW MECHANISMS OF INFECTIOUS PATHOLOGY.

GENETIC DISEASES. DISEASES CAUSED BY GENETIC MUTATIONS. TRANSMISSIONS OF GENETIC DISEASES. TRANSMISSIONS OF MULTIFACTORIAL DISEASES. MAIN HUMAN DISEASES CAUSED BY KARYOTYPIC ANOMALIES.

PATHOLOGY OF THE CELL: MECHANISMS OF CELL DAMAGE AND ADAPTIVE CELL REACTIONS. MOLECULAR MECHANISMS OF CELL DAMAGE. HYPOXIC DAMAGE. OXIDATIVE STRESS: FREE RADICAL ORIGIN, LIPIDIC PEROXIDATION, PROTEIN AND DNA OXIDATION. ADAPTIVE CELL REACTIONS: HYPERTROPHY, HYPERPLASIA, ATROPHY. PHENOTYPIC CHANGES: METAPLASIA, DISPLASIA, ANAPLASIA. CELL DEGENERATION: HYDROPIC DEGENERATION; VACUOLAR DEGENERATION; EXCESSIVE DEPOSIT OF INTRACELLULAR MATERIAL, STEATOSIS. CELL DEATH: CELL NECROSIS AND APOPTOSIS. AGING.

INFLAMMATION. BASIC CONCEPTS: ACUTE AND CHRONIC INFLAMMATION; VASCULAR AND TISSUE INVOLVEMENT IN INFLAMMATION. RECEPTORS OF INNATE IMMUNITY AND INFLAMMATION. TRANSCRIPTIONAL PROGRAM IN INFLAMMATION. INFLAMMATORY CELLS. CHEMICAL MEDIATORS OF INFLAMMATION: CELLULAR AND HUMORAL ORIGIN. ACUTE INFLAMMATION: VASCULAR PHENOMENA, EXTRACELLULAR FLUIDS AND OEDEMA, DIFFERENT TYPES OF ACUTE INFLAMMATION. CHRONIC INFLAMMATION: GRANULOMA FORMATION. BODY GRANULOMAS. IMMUNOLOGICAL GRANULOMAS. SYSTEMIC EFFECTS OF INFLAMMATION AND THEIR REGULATION: ACUTE PHASE PROTEINS, RATE OF ERYTHROSEDIMENTATION, LEUKOCYTOSIS. PHYSIOPATHOLOGY OF TERMOREGULATION: FEVER. REGULATION OF INFLAMMATORY PROCESS.

REPAIR. PHASES OF TISSUE DAMAGE REPAIR. ANGIOGENESIS AND ANGIOGENETIC FACTORS. FIBROBLAST PROLIFERATION, EXTRACELLULAR MATRIX DEPOSITION AND INVOLVED FACTORS. REMODELLING. WOUND HEALING. HEALING OF FIRST AND SECOND INTENTION. PATHOLOGICAL ASPECTS OF WOUND HEALING: KELOIDS. REGENERATION: MODELS OF TISSUE REGENERATION. STEM CELLS.

ONCOLOGY: DEFINITIONS AND CLASSIFICATIONS. DEFINITIONS OF TUMORS AND PRE-CANCEROUS CONDITIONS. MORPHOLOGICAL AND BIOCHEMICAL CHARACTERISTICS OF NEOPLASTIC CELLS. HISTOGENETIC TUMOR CLASSIFICATIONS. CLINCIAL CRITERIA OF TUMOR CLASSIFICATIONS: GRADING AND STAGING. MOLECULAR AND GENETIC BASIS OF CANCER. PHYSIOPATHOLOGY OF CELL PROLIFERATION AND DIFFERENTIATION AND GROWTH FACTORS. PHYSICAL, CHEMICAL, VIRAL AND ORMONAL CANCEROGENESIS. IMMUNITY, INFLAMMATION AND TUMORS. ONCOGENES AND THEIR ACTIVATION. ONCOSUPPRESSOR GENES. GENOMIC INSTABILITY. HEREDITARY TUMORS. NEOPLASTIC PROCESS: INITIATION, PROMOTION AND PROGRESSION. MOLECULAR BASIS OF INVASIVENESS. METASTATIC SPREAD. FAVORING FACTORS FOR METASTATIC GROWTH.

PRIMARY METABOLIC DISEASES. BASIC CONCEPTS OF AMINOACID METABOLISM AND PHENYLKETONURIA, GLUCIDIC METABOLISM AND DIABETES, LIPIDIC METABOLISM AND DYSLIPIDEMIAS.

GENERAL PATHOPHYSIOLOGY: PATHOPHYSIOLOGY OF METABOLISM (AMINO ACIDS, PURINE AND PIRIMIDINICHE, LIPID AND DYSLIPIDEMIA).

GENERAL PHYSIOPATHOLOGY OF HAEMATOPOIEC ORGANS AND HAEMOSTASIS.

PATOLOGIA GENERALE, G.M. PONTIERI ET AL., VOL I, VOL II, PICCIN, 2010
PATOLOGIA GENERALE-PATOLOGIA D’ORGANO E MOLECOLARE, R. RUBIN ET AL, PICCIN, 2014
PATOLOGIA GENERALE CON ELEMENTI DI FISIOPATOLOGIA. ROBBINS, ED. EDRA 2013

LIBRI DA CONSULTARE

LE BASI PATOLOGICHE DELLE MALATTIE, ROBBINS, VIII ED., VOL I, ELSEVIER, 2010
(IX EDIZIONE IN USCITA NEL 2015)

PATOLOGIA, STEVENS, J. LOWE, III ED., CASA ED. AMBROSIANA, 2010