Università Roma Tre

Molecular and Cell Biophysics (3 CFU). Amino acids, protein structure, hemoglobin, myoglobin, enzymes, enzyme catalysis, enzyme activation, enzyme inhibition, carbohydrates, glycolysis, Krebs cycle, oxidative phosphorylation, lactate biosynthesis, alcoholic fermentation, lipids, beta-oxidation, amino acid and protein catabolism, urea cycle. The cell compartimentation, The energy of living organisms. Tissues organization. Membrane dynamic structure, functions and dynamics of cell plasma membranes. Junctions, channels, receptors. Permeability, diffusion, osmosys, tonicity. Plasma membrane transport systems: facilitate, primary and secondary active transport. Endocytosis-exocytosis. Ion transport.

Biophysics of Homeostatic Systems (3 CFU): central nervous system and autonomous nervous system. Electrical properties of the cell plasma membrane, genesis of the transplasma membrane potential, excitability, resting membrane potential, electrotonic and action potential. Propagation and transmission of electric signals. Synapses. Neuronal plasticity. Somatic and autonomous reflex arc. Sensory physiology. Hormones. Cell communication, general properties of the endocrine system, chemical structure and release of hormones. Hormone signal transduction.

Physiology of organs and systems (3 CFU): muscle system. Skeletal, smooth, cardiac muscle. Mechanic of the skeletal muscle contraction. Myogram. Refractory period. Tetanic contraction. Control of the muscle contraction. Fatigue. Cardiovascular system. Electrical properties of the heart, potentials of pacemaker cells and working myocardium, the heart as a pump. Intrinsic and extrinsic regulation of the heart cardiac output. Vascular system, flux, artery pressure and its regulation. The blood. Properties, globular resistance, blood distribution to tissues. Coagulation. Respiratory system. Respiratory mechanic, ventilation, exchange and transport of gases, ph regulation, regulation of ventilation. Basis of gastro-intestinal physiology. Renal system. Glomerular filtration, reassorbtion, secretion, excretion. Hormone regulation of the renal function. Digestive system. Motility, secretion, digestion, absorption of carbohydrates, lipids and proteins.

MAIN TEXTBOOK: D.U. SILVERTHORN Human Physiology 2010 Pearson Education inc

BOOKS FOR DEEPENING KNOWLEDGE: (AVAILABLE IN THE SCIENTIFIC LIBRARY) HILL R, WYSE G, ANDERSON M FISIOLOGIA ANIMALE 2006 ZANICHELLI; RANDALL D. ET AL., FISIOLOGIA ANIMALE ZANICHELLI; CASELLA C. E TAGLIETTI V. PRINCIPI DI FISIOLOGIA ED. LA GOLIARDICA PAVESE; BERNE R.M. E LEVY M.N. PRINCIPI DI FISIOLOGIA CASA EDITRICE AMBROSIANA.