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Su richiesta degli studenti, tramite e-mail (valentina.cianfanelli@uniroma3.it)

Curriculum

Docente del modulo di: -"Anatomia comparata", facente parte del corso integrato di "Anatomia comparata e biologia dello sviluppo" - Corso di Laurea in "Scienze biologiche" -"Biologia dello sviluppo ed anatomia comparata", facente parte del corso integrato di "Biologia cellulare ed elementi di genetica" - Corso di Laurea in "Scienze per la protezione della natura e la sostenibilita' ambientale L-32" VALENTINA CIANFANELLI ORCID ID: 0000-0002-3857-9463 Scopus ID: 55006049100 RESEARCH EXPERIENCE 06/2022-Present: Assistant Prof. at the Depart. of Science, University Roma TRE (Rome, Italy) 04/2020-05/2022: Fondazione Umberto Veronesi (FUV) Fellow at the Depart. of Pediatric Hemato-Oncology and Cell and Gene therapy, Ospedale Pediatrico Bambino Gesú (OPBG, Rome, Italy) 10/2018-03/2020: Senior Scientist at the Cell Stress and Survival Unit, Danish Cancer Society Research Center (DCRC, Copenhagen, Denmark) 06/2014-09/2018: Postdoctoral Fellow, DCRC (Copenhagen, Denmark) 02/2016-03/2016: Visiting Scientist. CRUK-Beatson (Glasgow, United Kingdom) 11/2012-05/2014: Postdoc (FILAS Fellow) at the Depart. of Biology, Univ. of Rome Tor Vergata (Italy) 11/2009-10/2012: PhD fellow, PhD in Cellular and Molecular Biology, Univ. of Rome Tor Vergata (Italy) 10/2008-10/2009: Undergraduate Student at the Depart. of Biology, Univ. of Rome Tor Vergata (Italy) EDUCATION 12/2012: Ph.D. degree in Cellular and Molecular Biology, Univ. of Rome Tor Vergata (Italy) 10/2009: M.Sc. in Cellular and Molecular Biology, Univ. of Rome Tor Vergata (Italy). 110/110 Cum Laude 10/2007: B.Sc. in Cellular and Molecular Biology, Univ. of Rome Tor Vergata (Italy). 110/110 Cum Laude FUNDING 11/2024: PRIN 2022 PNRR Under 40 (Principal Investigator) 05/2023: Ricerca Finalizzata Giovani Ricercatori (Principal Investigator) 06/2021: LILT (Lega Italiana per la Lotta contro i Tumori) (Principal Investigator) 04/2020; 04/2021 and 04/2022: Fondazione Umberto Veronesi Postdoc Fellowships 06/2016: Kræftens Bekæmpelse (KB) Individual Postdoc Fellowship 05/2016: Lundbeckfonden Individual Postdoc Fellowship 12/2015: KB Travel Grant to visit the CRUK-Beatson (Glasgow, UK) 08/2015: KB Travel Grant to attend the Autophagy EMBO Conference (Chia, Italy) 06/2014: Lundbeckfonden Individual Postdoc Fellowship AWARDS and ACHIEVEMENTS 2017-Present: A Committee appointed by the Italian Ministry of University and Research judged myself eligible to teach at University level as Associate Professor in “Comparative Anatomy and Cytology” 2022: Best-Talk Prize at the Nordic Autophagy Society (NAS) Conference (Copenhagen, Denmark) 2019: Best-Poster Prize at the Autophagy EMBO Conference (Crieff, Scotland) 2017: EMBO Postdoc Support Grant awarded by the Organizers of the EMBO “Europhosphatase” Conference (Paris, France) SELECTED PARTECIPATIONS AT INTERNATIONAL MEETINGS -09/2022: BEST-TALK PRIZE 5th Nordic Autophagy Society Conference (Copenhagen, Denmark) 08/2019: BEST-POSTER PRIZE Autophagy EMBO Conference (Crieff, Scotland) 07/2017: CO-CHAIR at the EMBO Europhosphatase Conference (Paris, France) 03/2017: INVITED SPEAKER at 47th Annual Scand-LAS (Scandinavian Society for Laboratory Animal Science) Conference (Copenhagen, Denmark) Selected Speaker at: 08/2018: 2nd Nordic Autophagy Society Conference (Riga, Latvia) 08/2016: 5th Conference of the Nordic Autophagy Network (Keflavik, Iceland) 06/2015: 4th Conference of the Nordic Autophagy Network (Helsinki, Finland) • Top-choice speaker award of the Organizing Committee 09/2014: 1st Joint Meeting of the Nordic, Spanish & French (NSF) Autophagy Networks (Toulouse, France) 06/2013: Gordon Research Seminar on Cell Growth & Proliferation (West Dover, USA) 09/2012: 20th Euroconference on apoptosis - ECDO (Rome, Italy) EDITORIAL ACTIVITY 04/2019: Guest Editor for Frontiers in Cell and Developmental Biology. Special issue: “Molecular mechanisms of selective autophagy in human diseases” COMMISSION OF TRUST and REVIEWING ACTIVITY Since 2024: Grant peer-reviewer for the Foundation Mia Neri and for the International Research Office of the Sapienza University of Rome Since 2018: Grant peer-reviewer for the French National Research Agency (ANR) Since 2018: External evaluator for the PhD Programme in Cellular and Molecular Biology at the Univ. of Rome Tor Vergata Since 2014: Member of the Nordic Autophagy Society Since 2011: Peer-reviewer for the following journals: Nature Structural&Molecular Biology, Autophagy, Cell Death&Disease, FEBS Letter, Molecular Oncology, Oncogene and PLOS ONE ORGANIZATION OF SCIENTIFIC MEETINGS 2020-2022: member of the Seminar Committee of the Depart. of Pediatric Hemato-Oncology and Cell and Gene therapy, Ospedale Pediatrico Bambino Gesú (OPBG, Rome, Italy) 2014-2020: member of the DCRC Seminar Committee SUPERVISION ACTIVITY I supervised Bachelor and Master students. I co-supervised a PhD student, Dr. K. Hartfelt, enrolled at the Univ. of Copenhagen (MoMed PhD school, Denmark). She recently successfully defended her PhD, was awarded with the “Best Talk” prize at the 5th Nordic Autophagy Society (NAS) conference (Sept. 2022, Copenhagen, Denmark). I currently supervise 2 PhD student, and 3 post docs. LIST OF PUBLICATIONS Total number of publications 35 + 2 Book Chapters • 9 publications as first author, and 1 as co-corresponding author Total number of citations 8686 H-index 25 (source: Scopus) 1. Migliore L, CIANFANELLI V, Zevolini F, Gesualdo M, Marzuoli L, Patrussi L, Ulivieri C, Marotta G, Cecconi F, Finetti F, Baldari CT. (2024) An AMBRA1, ULK1 and PP2A regulatory network regulates cytotoxic T cell differentiation via TFEB activation. SCI REP, 14(1):31838. 2. Faienza F., Polverino F, Rajendraprasad G, Milletti G, Hu Z, Colella B, Gargano D, Strappazzon F, Rizza S, Vixø Vistesen M, Luo Y, Antonioli M, CIANFANELLI V, Ferraina C, Fimia GM, Filomeni G, De Zio D, Dengjel J, Barisic M, Guarguaglini G, Di Bartolomeo S, Cecconi F. (2023) AMBRA1 phosphorylation by CDK1 and PLK1 regulates mitotic spindle orientation. CELL MOL LIFE SCI, 80(9):251 3. Logli E, Marzuolo E, D'Agostino M, Conti LA, Lena AM, Diociaiuti A, Dellambra E, Has C, CIANFANELLI V, Zambruno G. (2022) Proteasome-mediated degradation of keratins 7, 8, 17 and 18 by mutant KLHL24 in a foetal keratinocyte model: Novel insight in congenital skin defects and fragility of epidermolysis bullosa simplex with cardiomyopathy. HUMAN MOLECULAR GENETICS ONLINE, 31(8):1308-1324 4. Maiani E*, Milletti G*, Nazio F, Holdgaard SG, Bartkova J, Rizza S, CIANFANELLI V, Lorente M, Simoneschi D, Di Marco M, D’Acunzo P, di Leo L, Rasmussen R, Montagna C, Raciti M, De Stefanis C, Gabicagogeascoa E, Rona G, Salvador N, Pupo E, Merchut-Maya JM, Daniel CJ, Carinci M, Cesarini V, O´sullivan A, Jeong Y-T, Bordi M, Russo F, Campello S, Gallo A, Filomeni G, Lanzetti L, Sears RC, Hamerlik P, Bartolazzi A, Hynds RE, Pearce Dr, Swanton C, Pagano M, Velasco G, Papaleo E, De Zio D, Maya-Mendoza A, Locatelli F, Bartek J#, Cecconi F#. (2021) AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity. NATURE, 592(7856):799-803 *These authors contributed equally; #Co-last authors 5.Simoneschi D., Rona G, Zhou N, Jeong Y-T, Milletti G, Jiang S, Arbini, AA, O’sullivan A, Wang AA, Nithikasem S, Boccalatte F, Keegan S, Siu Y, CIANFANELLI V, Maiani E, Nazio F, Cecconi F, Fenyö D, Jones DR, Busino L, Pagano M. (2021) CRL4AMBRA1 is a master regulator of D-type Cyclins. NATURE, 592(7856):789-793 6. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, [...], CIANFANELLI V, [...] & Tong C. (2021) Guidelines for the use and interpretation of assays monitoring autophagy (4th edition). AUTOPHAGY, 17(1):1-382 7.CIANFANELLI V, Grumati P, Nazio F. (2020) Editorial: Molecular Mechanisms of Selective Autophagy in Human Disease. FRONT CELL DEV BIO, 6(8):664 8. CIANFANELLI V*, and Cecconi F*. (2020) Doryphagy: when selective autophagy safeguards centrosome integrity. MOL CELL ONCOL, 7(2):1719021 *Co-corresponding authors 9. Holdgaard S, CIANFANELLI V, and Cecconi F. (2019) Cloud hunting: doryphagy, a form of selective autophagy that degrades centriolar satellites. AUTOPHAGY, 16(2):379-381 10. Holdgaard S#, CIANFANELLI V#, Pupo E, Lambrughi M, Lubas M, Nielsen JC, Maiani E,Harder LM, Wesch N, Eibes S, Nazio F, de la Ballina LR, Dötsch V, Brech A, Frankel LB, Barisic M, Andersen JS, Bekker-Jensen S, Lund A-H, Rogov VV, Papaleo E, Lanzetti L, De Zio D, and Cecconi F. (2019) Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites. NAT COMMUN, 10(1):4176 #These authors contributed equally 11. Lim YC, Ensbey KS, Offenhäuser C, D’Souza RCJ, Cullen JK, Stringer BW, Quek H, Bruce ZC, Kijas A, CIANFANELLI V, Mahboubi B, Smith F, Jeffree RL, Wiesmüeller L, Wiegmans AP, Bain A, Lombard FJ, Roberts TL, Khanna KK, Lavin MF, Baek K., Hamerlik P, Johns TG, Coster MJ, Boyd MW and Day BW. (2019) Simultaneous Targeting of DNA Replication and Homologous Recombination in Glioblastoma with a Polyether Ionophore. NEURO-ONCOLOGY, 22(2):216-228 12. Finetti F, Cassioli C, CIANFANELLI V, Onnis A, Paccagnini E, Kabanova A, Baldari CT. (2019) The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases. CELL DEATH DIFFER, 27(1):310-328 13. Nazio F#, Bordi M#, CIANFANELLI V, Locatelli F., Cecconi F. (2019) Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications. CELL DEATH AND DIFF, 26(4):690-702 #These authors contributed equally 14. Becher J, Simula L, Volpe E, Procaccini C, La Rocca C, D’Acunzo P, CIANFANELLI V, Strappazzon F, Caruana I, Nazio F, Weber G, Gigantino V, Botti G, Ciccosanti F, Borsellino G, Campello S, Mandolesi G, De Bardi M, Fimia GM, D’Amelio M, Ruffini F, Furlan R, Centonze D, Martino G, Braghetta P, Chrisam M, Bonaldo P, Matarese G, Locatelli F, Battistini L, Cecconi F. (2018) AMBRA1 Controls Regulatory T-Cell Differentiation and Homeostasis Upstream of the FOXO3-FOXP3 Axis. DEV CELL 47(5):592-607.e6 15. Russo R, Varano GP, Adornetto A, Nazio F, Tettamanti G, Girardello R, CIANFANELLI V, Cavaliere F, Morrone LA, Corasaniti MT, Cecconi F, Bagetta G, Nucci C. (2018) Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival. CELL DEATH DIS 9(10):981 16. Onnis A, CIANFANELLI V, Cassioli C, Samardzic D, Pelicci PG, Cecconi F & Baldari CT. The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II. AUTOPHAGY, 14(12):2117-2138 • Cover Article, Autophagy, 14 (12) 17. Capizzi MC, Strappazzon F, CIANFANELLI V, Papaleo E & Cecconi F. (2017) MIR7-3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1. AUTOPHAGY, 2(5):554-556 18. Corrado M, Mariotti F, Trapani L, Tarabborelli L, Nazio F, CIANFANELLI V, Soriano ME, Shrepfer E, Cecconi F, Scorrano L & Campello S. (2016) Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis. EMBO J, 35(16):1793-1809 19. Strappazzon F, Di Rita A, CIANFANELLI V, D’Orazio M, Nazio F, Fimia GM & Cecconi F. (2016) Pro-survival AMBRA1 turns into a pro-apoptotic BH3-like protein during mitochondrial apoptosis. AUTOPHAGY, 12(6):963-975 20. Klionsky DJ, Abdelmohsen K, Abe A, […], CIANFANELLI V, [...] & Zughaier SM. (2016) Guidelines for the use and interpretation of assays monitoring autophagy (3rd edition). AUTOPHAGY, 12(1):1-222 21. CIANFANELLI V & Cecconi F. (2015) AMBRA1: When autophagy meets cell proliferation. AUTOPHAGY, 11 (9),1705-1707 22. CIANFANELLI V, De Zio D, Di Bartolomeo S, Nazio F, Strappazzon F & Cecconi F. (2015) Ambra1 at a glance. J CELL SCI, 28 (11), 2003-2008 23. Tatti M, Motta M, Scarpa S, Di Bartolomeo S, CIANFANELLI V, Tartaglia M & Salvioli R. (2015) BCM-95 and (2-hydroxypropyl)-β-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts. HUM MOL GENET, 24(15), 4198-4211 24. CIANFANELLI V, D'Orazio M & Cecconi F. (2015) AMBRA1 and BECLIN 1 interplay in the crosstalk between autophagy and cell proliferation. CELL CYCLE, 14(7), 959-963 25. Niso-Santano M, Malik SA, Pietrocola F, Bravo-San Pedro JM, Mariño G, CIANFANELLI V, Ben-Younès A, Troncoso R, Markaki M, Sica V, Izzo V, Chaba K, Bauvy C, Dupont N, Kepp O, Rockenfeller P, Wolinski H, Madeo F, Lavandero S, Codogno P, Harper F, Pierron G, Tavernarakis N, Cecconi F, Maiuri MC, Galluzzi L & Kroemer G. (2015) Unsaturated fatty acids induce non-canonical autophagy. EMBO J, 34 (8), 1025-1041 26. CIANFANELLI V, Nazio F & Cecconi F. (2015) Connecting autophagy: AMBRA1 and its network of regulation. MOLECULAR & CELLULAR ONCOLOGY, 2(1), e970059 27. CIANFANELLI V, Fuoco C, Lorente M, Salazar M, Quondamatteo F, Gherardini PF, De Zio D, Nazio F, Antonioli M, D'Orazio M, Skobo T, Bordi M, Rohde M, Dalla Valle L, Helmer-Citterich M, Gretzmeier C, Dengjel J, Fimia GM, Piacentini M, Di Bartolomeo S, Velasco G & Cecconi F. (2015) AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. NAT CELL BIOL, 17(1), 20-30 • Cover Article, Nat. Cell Biol., 17 (1) 28. Strappazzon F, Nazio F, Corrado M, CIANFANELLI V, Romagnoli A, Fimia GM, Campello S, Nardacci R, Piacentini M, Campanella M & Cecconi F. (2015) AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1. CELL DEATH DIFFER, 22(3), 419-432 29. Skobo T, Benato F, Grumati P, Meneghetti G, CIANFANELLI V, Castagnaro S, Chrisam M, Di Bartolomeo S, Bonaldo P, Cecconi F & Dalla Valle L. (2014) Zebrafish ambra1a and ambra1b knockdown impairs skeletal muscle development. PLoS ONE, 9(6), e99210 30. CIANFANELLI V & Cecconi F. (2013) Cell biology: Molecular clearance at the cell's antenna. Nature, 502 (7470), 180-181 31. Nazio F, Strappazzon F, Antonioli M, Bielli P, CIANFANELLI V, Bordi M, Gretzmeier C, Dengjel J, Piacentini M, Fimia GM & Cecconi F. (2013) mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. NAT CELL BIOL, 15 (4), 406-416 32. Tatti M, Motta M, Di Bartolomeo S, CIANFANELLI V & Salvioli R. (2013) Cathepsin-mediated regulation of autophagy in saposin C deficiency. AUTOPHAGY, 9 (2), 241-243 33. De Zio D, CIANFANELLI V & Cecconi F. (2013) New insights into the link between DNA damage and apoptosis. ANTIOXID REDOX SIGNAL, 19 (6), 559-571 34. Tatti M, Motta M, Di Bartolomeo S, Scarpa S, CIANFANELLI V, Cecconi F & Salvioli R. (2012) Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts. HUM MOL GENET, 21 (23), 5159-5173 35. CIANFANELLI V & Cecconi F. (2012) Autophagy-dependent NFκB regulation. CELL CYCLE, 11 (3), 436-437 BOOK CHAPTERS 1. CIANFANELLI V & Cecconi F. (2013) “Chapter 7 – Developmental autophagy” pg. 103-116 of the book Autophagy in Health and Disease – 1st edition. R. Gottlieb Editor, ELSEVIER. ISBN: 9780123851024 2. CIANFANELLI V & Cecconi F. (2017) “Chapter 18 - AMBRA1-mediated regulation of c-MYC and its relevance to cancer” pg. 373-385 of the book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. M. A. Hayat Editor, EL