Orari di ricevimento

Ricevimento previo appuntamento via e-mail

Curriculum

Education and Degrees: 1998 Bachelor of Science degree from the University of Rome “Tor Vergata”, Italy. Awarded an interdisciplinary degree in Molecular Biology. Advisor: Prof. Vittorio Colizzi 2001-2005 Doctor of Philosophy degree from the University of Rome “Tor Vergata”, Italy. Awarded a degree by the Program in Immunology. Ph.D thesis entitled “Cellule dendritiche e patogenesi indotta da HIV: ruolo svolto nell’induzione di citochine Th2-like. ” Advisor: Prof. Vittorio Colizzi. Research positions: 1998-1999 Fellowship at the laboratory of Molecular Biology and Biophysics, Institute of Experimental Medicine, National Council of Research, Rome, Italy. 1999-2000 Research fellow at the "Department of Research" of Kantonsspital, Basel, Swizterland. Laboratory of Experimental Immunology. 2001-2004 Research fellow, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome Italy. Laboratory of Cellular Immunology. 2005-2006 Fellowship from Ministry of Health, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome Italy. Laboratory of Cellular Immunology. 2007-2022 Researcher, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome Italy. Laboratory of Cellular Immunology and Pharmacology. 2022-present Researcher, University of Roma3, Department of Science, Laboratory of Molecular Virology and Antimicrobial Immunity. Scientific Publications 1. Ciccosanti F, Antonioli M, Sacchi A, Notari S, Farina A, Beccacece A, Fusto M, Vergori A, D'Offizi G, Taglietti F, Antinori A, Nicastri E, Marchioni L, Palmieri F, Ippolito G, Piacentini M, Agrati C, Fimia GM. Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation. Clin Proteomics. 2022 Nov 8;19(1):38. doi: 10.1186/s12014-022-09377-7. 2. Agrati C, Castilletti C, Battella S, Cimini E, Matusali G, Sommella A, Sacchi A, Colavita F, Contino AM, Bordoni V, Meschi S, Gramigna G, Barra F, Grassi G, Bordi L, Lapa D, Notari S, Casetti R, Bettini A, Francalancia M, Ciufoli F, Vergori A, Vita S, Gentile M, Raggioli A, Plazzi MM, Bacchieri A, Nicastri E, Antinori A, Milleri S, Lanini S, Colloca S, Girardi E, Camerini R, Ippolito G, Vaia F, Folgori A, Capone S. Safety and immune response kinetics of GRAd-COV2 vaccine: phase 1 clinical trial results. NPJ Vaccines. 2022 Sep 24;7(1):111. doi: 10.1038/s41541-022-00531-8. 3. Corradini P, Agrati C, Apolone G, Mantovani A, Giannarelli D, Marasco V, Bordoni V, Sacchi A, Matusali G, Salvarani C, Zinzani PL, Mantegazza R, Tagliavini F, Lupo-Stanghellini MT, Ciceri F, Damian S, Uccelli A, Fenoglio D, Silvestris N, Baldanti F, Piaggio G, Ciliberto G, Morrone A, Locatelli F, Sinno V, Rescigno M, Costantini M; VAX4FRAIL Study Group. Humoral and T-cell immune response after three doses of mRNA SARS-CoV-2 vaccines in fragile patients: the Italian VAX4FRAIL study. Clin Infect Dis. 2022 May 24: ciac404. doi: 10.1093/cid/ciac404. 4. Antinori A, Cicalini S, Meschi S, Bordoni V, Lorenzini P, Vergori A, Lanini S, De Pascale L, Matusali G, Mariotti D, Cozzi Lepri A, Gallì P, Pinnetti C, Gagliardini R, Mazzotta V, Mastrorosa I, Grisetti S, Colavita F, Cimini E, Grilli E, Bellagamba R, Lapa D, Sacchi A, Marani A, Cerini C, Candela C, Fusto M, Puro V, Castilletti C, Agrati C, Girardi E, Vaia F; HIV-VAC Study Group. Humoral and Cellular Immune Response Elicited by mRNA Vaccination Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in People Living with Human Immunodeficiency Virus Receiving Antiretroviral Therapy Based on Current CD4 T-Lymphocyte Count. Clin Infect Dis. 2022 Aug 24;75(1):e552-e563. doi: 10.1093/cid/ciac238. 5. Vergori A, Cozzi Lepri A, Cicalini S, Matusali G, Bordoni V, Lanini S, Meschi S, Iannazzo R, Mazzotta V, Colavita F, Mastrorosa I, Cimini E, Mariotti D, De Pascale L, Marani A, Gallì P, Garbuglia A, Castilletti C, Puro V, Agrati C, Girardi E, Vaia F, Antinori A; HIV-VAC study group. Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV. Nat Commun. 2022 Aug 22;13(1):4922. doi: 10.1038/s41467-022-32263-7. 6. Agrati C, Carsetti R, Bordoni V, Sacchi A, Quintarelli C, Locatelli F, Ippolito G, Capobianchi MR. The immune response as a double-edged sword: the lesson learnt during the COVID-19 pandemic. Immunology. 2022 Aug 16. doi: 10.1111/imm.13564. 7. Grassi G., Notari S., Gili S., Bordoni V., Casetti R., Cimini E., Tartaglia E., Mariotti D., Agrati C., Sacchi A. Myeloid-Derived Suppressor Cells in COVID-19: The Paradox of Good. Frontiers in Immunology, 2022, 13, 842949. 8. Agrati C, Castilletti C, Goletti D, Sacchi A, Bordoni V, Mariotti D, Notari S, Matusali G, Meschi S, Petrone L, Aiello A, Najafi Fard S, Farroni C, Colavita F, Lapa D, Leone S, Agresta A, Capobianchi M, Ippolito G, Vaia F, Puro V; INMI COVID-19 Vaccine Study Group. Persistent Spike-specific T cell immunity despite antibody reduction after 3 months from SARS-CoV-2 BNT162b2-mRNA vaccine. Sci Rep. 2022 Apr 23;12(1):6687. doi: 10.1038/s41598-022-07741-z. 9. Pagano M.T., Peruzzu D., Busani L., Pierdominici M., Ruggieri A., Antinori A., D'Offizi G., Petrosillo N., Palmieri F., Piselli P., Cicalini S., Notari S., Nicastri E., Agrati C., Ippolito G., Vaia F., Gagliardi MC., Capobianchi MR., Ortona E., INMI-ISS COVID-19 team. Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers. Biology of Sex Differences, 2021, 12(1), 63. 10. Bordoni, V., Matusali, G., Mariotti, D., Antonioli, M., Cimini, E., Sacchi, A., Tartaglia, E., Casetti, R., Grassi, G., Notari, S., Castilletti, C., Fimia, G.M., Capobianchi, M.R., Ippolito, G., Agrati, C. The interplay between SARS-CoV-2 infected airway epithelium and immune cells modulates regulatory/inflammatory signals. iScience, 2022, 25 (2), art. no. 103854. 11. Lanini S, Capone S, Antinori A, Milleri S, Nicastri E, Camerini R, Agrati C, Castilletti C, Mori F, Sacchi A, Matusali G, Gagliardini R, Ammendola V, Cimini E, Grazioli F, Scorzolini L, Napolitano F, Plazzi MM, Soriani M, De Luca A, Battella S, Sommella A, Contino AM, Barra F, Gentile M, Raggioli A, Shi Y, Girardi E, Maeurer M, Capobianchi MR, Vaia F, Piacentini M, Kroemer G, Vitelli A, Colloca S, Folgori A, Ippolito G. GRAd-COV2, a gorilla adenovirus-based candidate vaccine against COVID-19, is safe and immunogenic in younger and older adults. (2022) Science Translational Medicine, 14 (627). 12. Montaldo, C., Messina, F., Abbate, I., Antonioli, M., Bordoni, V., Aiello, A., Ciccosanti, F., Colavita, F., Farroni, C., Najafi Fard, S., Giombini, E., Goletti, D., Matusali, G., Rozera, G., Rueca, M., Sacchi, A., Piacentini, M., Agrati, C., Fimia, G.M., Capobianchi, M.R., Lauria, F.N., Ippolito, G. Multi-omics approach to COVID-19: a domain-based literature review. (2021) Journal of Translational Medicine, 19 (1). 13. Vergori A, Lorenzini P, Cozzi-Lepri A, Donno DR, Gualano G, Nicastri E, Iacomi F, Marchioni L, Campioni P, Schininà V, Cicalini S, Agrati C, Capobianchi MR, Girardi E, Ippolito G, Vaia F, Petrosillo N, Antinori A, Taglietti F; ReCOVeRI Study Group. Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumonia. (2021) Scientific Reports, 11 (1). 14. Sacchi, A., Grassi, G., Notari, S., Gili, S., Bordoni, V., Tartaglia, E., Casetti, R., Cimini, E., Mariotti, D., Garotto, G., Beccacece, A., Marchioni, L., Bibas, M., Nicastri, E., Ippolito, G., Agrati, C. Expansion of myeloid derived suppressor cells contributes to platelet activation by l-arginine deprivation during sars-cov-2 infection. (2021) Cells, 10 (8). 15. Agrati, C., Sacchi, A., Tartaglia, E., Vergori, A., Gagliardini, R., Scarabello, A., Bibas, M. The role of p-selectin in covid-19 coagulopathy: An updated review. (2021) International Journal of Molecular Sciences, 22 (15), art. no. 7942. 16. Messina, F., Montaldo, C., Abbate, I., Antonioli, M., Bordoni, V., Matusali, G., Sacchi, A., Giombini, E., Fimia, G.M., Piacentini, M., Capobianchi, M.R., Lauria, F.N., Ippolito, G. Rationale and criteria for a covid-19 model framework. (2021) Viruses, 13 (7). 17. Agrati, C., Castilletti, C., Sacchi, A., Colavita, F., Capobianchi, M.R., Puro, V., Nicastri, E., Ippolito, G., Bibas, M. Immunogenicity and safety of BNT162b2 COVID-19 vaccine in a chronic lymphocytic leukaemia patient. (2021) Journal of Cellular and Molecular Medicine, 25 (13), pp. 6460-6462. 18. Agrati, C., Castilletti, C., Goletti, D., Meschi, S., Sacchi, A., Matusali, G., Bordoni, V., Petrone, L., Lapa, D., Notari, S., Vanini, V., Colavita, F., Aiello, A., Agresta, A., Farroni, C., Grassi, G., Leone, S., Vaia, F., Capobianchi, M.R., Ippolito, G., Puro, V., INMI COVID-190 Vaccine Study Group. Coordinate induction of humoral and spike specific t‐cell response in a cohort of italian health care workers receiving bnt162b2 mrna vaccine. (2021) Microorganisms, 9 (6). 19. Occhigrossi, L., Rossin, F., D’Eletto, M., Farrace, M.G., Ciccosanti, F., Petrone, L., Sacchi, A., Nardacci, R., Falasca, L., Nonno, F.D., Palucci, I., Smirnov, E., Barlev, N., Agrati, C., Goletti, D., Delogu, G., Fimia, G.M., Piacentini, M. Transglutaminase 2 regulates innate immunity by modulating the STING/TBK1/IRF3 axis. (2021) Journal of Immunology, 206 (10), pp. 2420-2429. 20. Grassi, G., Vanini, V., De Santis, F., Romagnoli, A., Aiello, A., Casetti, R., Cimini, E., Bordoni, V., Notari, S., Cuzzi, G., Mosti, S., Gualano, G., Palmieri, F., Fraziano, M., Goletti, D., Agrati, C., Sacchi, A. PMN-MDSC Frequency Discriminates Active Versus Latent Tuberculosis and Could Play a Role in Counteracting the Immune-Mediated Lung Damage in Active Disease. (2021) Frontiers in Immunology, 12. 21. Matusali, G., Colavita, F., Lapa, D., et al. Sars-cov-2 serum neutralization assay: A traditional tool for a brand-new virus. (2021) Viruses, 13 (4). 22. Mondi, A., Lorenzini, P., Castilletti, C., et al. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital. (2021) International Journal of Infectious Diseases, 105, pp. 532-539. 23. Bordoni, V., Tartaglia, E., Sacchi, A., Fimia, G.M., Cimini, E., Casetti, R., Notari, S., Grassi, G., Marchioni, L., Bibas, M., Capobianchi, M.R., Locatelli, F., Maeurer, M., Zumla, A., Antinori, A., Nicastri, E., Ippolito, G., Agrati, C. The unbalanced p53/SIRT1 axis may impact lymphocyte homeostasis in COVID-19 patients. (2021) International Journal of Infectious Diseases, 105, pp. 49-53. 24. Agrati, C., Bordoni, V., Sacchi, A., Petrosillo, N., Nicastri, E., Del Nonno, F., D'Offizi, G., Palmieri, F., Marchioni, L., Capobianchi, M.R., Antinori, A., Ippolito, G., Bibas, M. Elevated P-selectin in severe Covid-19: Considerations for therapeutic options. (2021) Mediterranean Journal of Hematology and Infectious Diseases, 13 (1). 25. Vita, S., Di Bari, V., Corpolongo, A., et al. Down Syndrome patients with COVID-19 pneumonia: A high-risk category for unfavourable outcome. (2021) International Journal of Infectious Diseases, 103, pp. 607-610. 26. Agrati, C., Sacchi, A., Bordoni, V., Cimini, E., Notari, S., Grassi, G., Casetti, R., Tartaglia, E., Lalle, E., D’Abramo, A., Castilletti, C., Marchioni, L., Shi, Y., Mariano, A., Song, J.-W., Zhang, J.-Y., Wang, F.-S., Zhang, C., Fimia, G.M., Capobianchi, M.R., Piacentini, M., Antinori, A., Nicastri, E., Maeurer, M., Zumla, A., Ippolito, G. Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19). (2020) Cell Death and Differentiation, 27 (11), pp. 3196-3207. 27. Bordoni, V., Sacchi, A., Cimini, E., Notari, S., Grassi, G., Tartaglia, E., Casetti, R., Giancola, M.L., Bevilacqua, N., Maeurer, M., Zumla, A., Locatelli, F., De Benedetti, F., Palmieri, F., Marchioni, L., Capobianchi, M.R., D'Offizi, G., Petrosillo, N., Antinori, A., Nicastri, E., Ippolito, G., Agrati, C. An inflammatory profile correlates with decreased frequency of cytotoxic cells in coronavirus disease 2019. (2020) Clinical Infectious Diseases, 71 (16), pp. 2272-2275. 28. Sacchi, A., Grassi, G., Bordoni, V., Lorenzini, P., Cimini, E., Casetti, R., Tartaglia, E., Marchioni, L., Petrosillo, N., Palmieri, F., D’Offizi, G., Notari, S., Tempestilli, M., Capobianchi, M.R., Nicastri, E., Maeurer, M., Zumla, A., Locatelli, F., Antinori, A., Ippolito, G., Agrati, C. Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcome. (2020) Cell Death and Disease, 11 (10). 29. Colavita, F., Lapa, D., Carletti, F., et al. SARS-CoV-2 isolation from ocular secretions of a patient with COVID-19 in Italy with prolonged viral RNA detection. (2020) Annals of Internal Medicine, 173 (3), pp. 242-243. 30. Bordoni, V., Tartaglia, E., Refolo, G., Sacchi, A., Grassi, G., Antinori, A., Fimia, G.M., Agrati, C. Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection. (2020) Frontiers in Cellular and Infection Microbiology, 10, art. no. 362. 31. Cimini, E., Sacchi, A., Grassi, G., Casetti, R., Notari, S., Bordoni, V., Forini, O., Grilli, E., Vergori, A., Capobianchi, M.R., Antinori, A., Agrati, C. Persistent gamma delta T-cell dysfunction in HCV/HIV co-infection despite direct-acting antiviral therapy-induced cure. (2020) Journal of Viral Hepatitis, 27 (7), pp. 754-756. 32. Albarello, F., Pianura, E., Di Stefano, F., et al. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation. (2020) International Journal of Infectious Diseases, 93, pp. 192-197. 33. Bordoni, V., Sacchi, A., Casetti, R., Cimini, E., Tartaglia, E., Pinnetti, C., Mondi, A., Gruber, C.E.M., Antinori, A., Agrati, C. Impact of ART on dynamics of growth factors and cytokines in primary HIV infection. (2020) Cytokine, 125, art. no. 154839. 34. Bordoni V, Brando B, Piselli P, Forini O, Perna FE, Atripaldi U, Carputo S, Garziano F, Trento E, D'Agosto G, Latini A, Colafigli M, Cristaudo A, Sacchi A, Andreoni M, De Carli G, Orchi N, Grelli S, Gatti A, Cerva C, Minutolo A, Potestà M, Di Martino ML, Ortu F, Selva P, Del Pup L, Guarnori I, Lorenzini P, Capuano G, Antinori A, Agrati C.Naïve/Effector CD4 T cell ratio as a useful predictive marker of immune reconstitution in late presenter HIV patients: A multicenter study. (2019) PLoS ONE, 14 (12). 35. Cimini, E., Sacchi, A., De Minicis, S., Bordoni, V., Casetti, R., Grassi, G., Colavita, F., Castilletti, C., Capobianchi, M.R., Ippolito, G., Desimio, M.G., Doria, M., Agrati, C. Vδ2 t-cells kill ZIKV-infected cells by NKG2D-mediated cytotoxicity. (2019) Microorganisms, 7 (9). 36. Casetti, R., Sacchi, A., Bordoni, V., Grassi, G., Cimini, E., Besi, F., Pinnetti, C., Mondi, A., Antinori, A., Agrati, C. In Human Immunodeficiency Virus primary infection, early combined antiretroviral therapy reduced γδ T-cell activation but failed to restore their polyfunctionality. (2019) Immunology, 157 (4), pp. 322-330. 37. Agrati, C., Tumino, N., Bordoni, V., Pinnetti, C., Sabatini, A., Amendola, A., Abbate, I., Lorenzini, P., Mondi, A., Casetti, R., Cimini, E., Grassi, G., Antinori, A., Sacchi, A. Myeloid derived suppressor cells expansion persists after early art and may affect CD4 T cell recovery. (2019) Frontiers in Immunology, 10 (AUG), art. no. 1886. 38. Sacchi, A., Tumino, N., Grassi, G., Casetti, R., Cimini, E., Bordoni, V., Ammassari, A., Antinori, A., Agrati, C. A new procedure to analyze polymorphonuclear myeloid derived suppressor cells in cryopreserved samples cells by flow cytometry. (2018) PLoS ONE, 13 (8), art. no. e0202920. 39. Sacchi, A., Tumino, N., Sabatini, A., Cimini, E., Casetti, R., Bordoni, V., Grassi, G., Agrati, C. Myeloid-derived suppressor cells specifically suppress IFN-γ production and antitumor cytotoxic activity of Vδ2 T cells. (2018) Frontiers in Immunology, 9 (JUN), art. no. 1271. 40. Bordoni, V., Viola, D., Sacchi, A., Pinnetti, C., Casetti, R., Cimini, E., Tumino, N., Antinori, A., Ammassari, A., Agrati, C. IL-18 and Stem Cell Factor affect hematopoietic progenitor cells in HIV-infected patients treated during primary HIV infection (2018) Cytokine, 103, pp. 34-37. 41. Cimini, E., Bordoni, V., Sacchi, A., Visco-Comandini, U., Montalbano, M., Taibi, C., Casetti, R., Lalle, E., D'Offizi, G., Capobianchi, M.R., Agrati, C. Intrahepatic Vγ9Vδ2 T-cells from HCV-infected patients show an exhausted phenotype but can inhibit HCV replication. (2018) Virus Research, 243, pp. 31-35. 42. Cimini, E., Castilletti, C., Sacchi, A., Casetti, R., Bordoni, V., Romanelli, A., Turchi, F., Martini, F., Tumino, N., Nicastri, E., Corpolongo, A., Di Caro, A., Kobinger, G., Zumla, A., Capobianchi, M.R., Ippolito, G., Agrati, C. Human Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells. (2017) Scientific Reports, 7 (1), art. no. 6313. 43. Sacchi, A., Tumino, N., Turchi, F., Refolo, G., Fimia, G., Ciccosanti, F., Montalbano, M., Lionetti, R., Taibi, C., D'Offizi, G., Casetti, R., Bordoni, V., Cimini, E., Martini, F., Agrati, C. Dendritic cells activation is associated with sustained virological response to telaprevir treatment of HCV-infected patients. (2017) Clinical Immunology, 183, pp. 82-90. 44. Tumino, N., Casetti, R., Fabbri, G., Cimini, E., Romanelli, A., Turchi, F., Forini, O., Bordoni, V., Antinori, A., Ammassari, A., Sacchi, A., Agrati, C. In HIV/HCV co-infected patients T regulatory and myeloid-derived suppressor cells persist after successful treatment with directly acting antivirals. (2017) Journal of Hepatology, 67 (2), pp. 422-424. 45. Casetti, R., Pinnetti, C., Sacchi, A., De Simone, G., Bordoni, V., Cimini, E., Tumino, N., Besi, F., Viola, D., Turchi, F., Mazzotta, V., Antinori, A., Martini, F., Ammassari, A., Agrati, C. HIV-Specific CD8 T Cells Producing CCL-4 Are Associated with Worse Immune Reconstitution during Chronic Infection. (2017) Journal of Acquired Immune Deficiency Syndromes, 75 (3), pp. 338-344. 46. Bordoni, V., Bibas, M., Viola, D., Sacchi, A., Cimini, E., Tumino, N., Casetti, R., Amendola, A., Ammassari, A., Agrati, C., Martini, F. Bone Marrow CD34+ Progenitor Cells from HIV-Infected Patients Show an Impaired T Cell Differentiation Potential Related to Proinflammatory Cytokines. (2017) AIDS Research and Human Retroviruses, 33 (6), pp. 590-596. 47. Cimini E, Viola D, Cabeza-Cabrerizo M, Romanelli A, Tumino N, Sacchi A, Bordoni V, Casetti R, Turchi F, Martini F, Bore JA, Koundouno FR, Duraffour S, Michel J, Holm T, Zekeng EG, Cowley L, Garcia Dorival I, Doerrbecker J, Hetzelt N, Baum JHJ, Portmann J, Wölfel R, Gabriel M, Miranda O, Díaz G, Díaz JE, Fleites YA, Piñeiro CA, Castro CM, Koivogui L, Magassouba N, Diallo B, Ruibal P, Oestereich L, Wozniak DM, Lüdtke A, Becker-Ziaja B, Capobianchi MR, Ippolito G, Carroll MW, Günther S, Di Caro A, Muñoz-Fontela C, Agrati C. Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections. (2017) PLoS Neglected Tropical Diseases, 11 (5), art. no. e0005645. 48. Tumino, N., Bilotta, M.T., Pinnetti, C., Ammassari, A., Antinori, A., Turchi, F., Agrati, C., Casetti, R., Bordoni, V., Cimini, E., Abbate, I., Capobianchi, M.R., Martini, F., Sacchi, A. Granulocytic myeloid-derived suppressor cells increased in early phases of primary HIV infection depending on TRAIL plasma level. (2017) Journal of Acquired Immune Deficiency Syndromes, 74 (5), pp. 575-582. 49. Bordoni, V., Sacchi, A., Cimini, E., Casetti, R., Tumino, N., Ammassari, A., Agrati, C., Martini, F. The Different Roles of Interleukin 7 and Interleukin 18 in Affecting Lymphoid Hematopoietic Progenitor Cells and CD4 Homeostasis in Naive Primary and Chronic HIV-Infected Patients. (2016) Clinical Infectious Diseases, 63 (12), pp. 1683-1684. 50. Riccomi, A., Gesa, V., Sacchi, A., De Magistris, M.T., Vendetti, S. Modulation of phenotype and function of human CD4+CD25+ T regulatory lymphocytes mediated by cAMP-elevating agents. (2016) Frontiers in Immunology, 7 (SEP), art. no. 358. 51. Agrati, C., Castilletti, C., Casetti, R., Sacchi, A., Falasca, L., Turchi, F., Tumino, N., Bordoni, V., Cimini, E., Viola, D., Lalle, E., Bordi, L., Lanini, S., Martini, F., Nicastri, E., Petrosillo, N., Puro, V., Piacentini, M., Di Caro, A., Kobinger, G.P., Zumla, A., Ippolito, G., Capobianchi, M.R. Longitudinal characterization of dysfunctional T cell-activation during human acute Ebola infection. (2016) Cell Death and Disease, 7 (3), art. no. e2164. 52. Casetti, R., De Simone, G., Sacchi, A., Rinaldi, A., Viola, D., Agrati, C., Bordoni, V., Cimini, E., Tumino, N., Besi, F., Martini, F. Vγ9Vδ2 T-cell polyfunctionality is differently modulated in HAART-treated HIV patients according to CD4 T-cell count. (2015) PLoS ONE, 10 (7), art. no. e0132291. 53. Cimini, E., Agrati, C., D'Offizi, G., Vlassi, C., Casetti, R., Sacchi, A., Lionetti, R., Bordoni, V., Tumino, N., Scognamiglio, P., Martini, F. Primary and chronic HIV infection differently modulates mucosal Vδ1 and Vδ2 T-cells differentiation profile and effector functions. (2015) PLoS ONE, 10 (6), art. no. e0129771. 54. El Daker, S, Sacchi, A., Tempestilli, M., Carducci, C., Goletti, D., Vanini, V., Colizzi, V., Lauria, F.N., Martini, F., Martino, A. Granulocytic myeloid derived suppressor cells expansion during active pulmonary tuberculosis is associated with high nitric oxide plasma level. (2015) PLoS ONE, 10 (4), art. no. e0123772. 55. Tumino, N., Turchi, F., Meschi, S., Lalle, E., Bordoni, V., Casetti, R., Agrati, C., Cimini, E., Montesano, C., Colizzic, V., Martini, F., Sacchi, A. In HIV-positive patients, myeloid-derived suppressor cells induce T-cell anergy by suppressing CD3 expression through ELF-1 inhibition. (2015) AIDS, 29 (18), pp. 2397-2407. 56. Sacchi, A., Rinaldi, A., Tumino, N., Casetti, R., Agrati, C., Turchi, F., Bordoni, V., Cimini, E., Martini, F. HIV infection of monocytes-derived dendritic cells inhibits Vc9Vd2 T cells functions. (2014) PLoS ONE, 9 (10), art. no. 0111095. 57. Bordoni, V., Casetti, R., Viola, D., Abbate, I., Rozera, G., Sacchi, A., Cimini, E., Tumino, N., Agrati, C., Orchi, N., Pinnetti, C., Ammassari, A., Martini, F. Early ART in primary HIV infection may also preserve lymphopoiesis capability in circulating haematopoietic progenitor cells: A case report. (2014) Journal of Antimicrobial Chemotherapy, 70 (5), pp. 1598-1600. 58. Casetti, R., De Simone, G., Sacchi, A., Bordoni, V., Viola, D., Rinaldi, A., Agrati, C., Gioia, C., Martini, F. Modulation of polyfunctional HIV-specific CD8 T cells in patients responding differently to antiretroviral therapy. (2014) International Journal of Immunopathology and Pharmacology, 27 (2), pp. 291-297. 59. Sacchi, A., Lapa, D., Garbuglia, A.R., Taibi, C., Tumino, N., D'Offizi, G., Martini, F. In HIV/HCV coinfected patients dendritic cell activation state is not associated with IL28B genotype. (2013) Journal of Infectious Diseases, 208 (2), pp. 364-365. 60. El Daker, S., Sacchi, A., Montesano, C., Altieri, A.M., Galluccio, G., Colizzi, V., Martini, F., Martino, A. An abnormal phenotype of lung Vγ9Vδ2 T cells impairs their responsiveness in tuberculosis patients. (2013) Cellular Immunology, 282 (2), pp. 106-112. 61. Bordoni, V., Bibas, M., Viola, D., Sacchi, A., Agrati, C., Castelli, G., Ammassari, A., Amendola, A., Abbate, I., Martini, F. Chronic HIV-infected patients show an impaired dendritic cells differentiation of bone marrow CD34+ cells. (2013) Journal of Acquired Immune Deficiency Syndromes, 64 (4), pp. 342-344. 62. Bordoni, V., Castelli, G., Montesoro, E., Federico, M., Sacchi, A., Morsilli, O., Agrati, C., Martini, F., Chelucci, C. HIV impairs CD34+-derived monocytic precursor differentiation into functional dendritic cells. (2013) International Journal of Immunopathology and Pharmacology, 26 (3), pp. 717-724. 63. Cimini, E., Bonnafous, C., Bordoni, V., Lalle, E., Sicard, H., Sacchi, A., Berno, G., Gioia, C., D'Offizi, G., Visco Comandini, U., Vlassi, C., Capobianchi, M.R., Martini, F., Agrati, C. Interferon-α improves phosphoantigen-induced Vγ9Vδ2 T-cells interferon-γ production during chronic HCV infection. (2012) PLoS ONE, 7 (5), art. no. e37014. 64. Sacchi, A., Agrati, C., D'Offizi, G., Vlassi, C., Martini, F. Co-stimulatory molecule CD80 expression may correlate with anti-HCV treatment outcome. (2011) Gut, 60 (8), pp. 1161-1162. 65. Sacchi, A., Agrati, C., D'Offizi, G., Vlassi, C., Rozera, G., Abbate, I., Capobianchi, M.R., Martini, F. The basal activation state of DC subsets correlates with anti-HCV treatment outcome in HCV/HIV co-infected patients. (2011) Clinical Immunology, 138 (2), pp. 178-186 66. 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Cutting edge: TGF-β1 and IL-15 induce FOXP3+ γδ regulatory T cells in the presence of antigen stimulation. (2009) Journal of Immunology, 183 (6), pp. 3574-3577. 70. Poccia, F., Gioia, C., Martini, F., Sacchi, A., Piacentini, P., Tempestilli, M., Agrati, C., Amendola, A., Abdeddaim, A., Vlassi, C., Malkovsky, M., D'Offizi, G. Zoledronic acid and interleukin-2 treatment improves immunocompetence in HIV-infected persons by activating Vγ9Vδ2 T cells. (2009) AIDS, 23 (5), pp. 555-565. 71. Sacchi, A., Tempestilli, M., Turchi, F., Agrati, C., Casetti, R., Cimini, E., Gioia, C., Martini, F. CD3ζ down-modulation may explain Vγ9Vδ2 T lymphocyte anergy in HIV-infected patients. (2009) Journal of Infectious Diseases, 199 (3), pp. 432-436. 72. Agrati, C., Cimini, E., Sacchi, A., Bordoni, V., Gioia, C., Casetti, R., Turchi, F., Tripodi, M., Martini, F. Activated Vγ9Vδ2 T cells trigger granulocyte functions via MCP-2 release. (2009) Journal of Immunology, 182 (1), pp. 522-529. 73. 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D'Offizi, G., Gioia, C., Corpolongo, A., Martini, F., Paganelli, R., Volpi, I., Sacchi, A., Tozzi, V., Narciso, P., Poccia, F. An IL-15 dependent CD8 T cell response to selected HIV epitopes is related to viral control in early-treated HIV-infected subjects. (2007) International Journal of Immunopathology and Pharmacology, 20 (3), pp. 473-485. 81. Sanarico, N., Ciaramella, A., Sacchi, A., Bernasconi, D., Bossù, P., Mariani, F., Colizzi, V., Vendetti, S. Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response. (2006) Journal of Leukocyte Biology, 80 (3), pp. 555-562. 82. Martino, A., Sacchi, A., Colizzi, V., Vendetti, S. Mycobacteria and dendritic cell differentiation: Escape or control of immunity (2006) Immunology Letters, 102 (1), pp. 115-117. 83. Martino, A., Sacchi, A., Volpe, E., Agrati, C., De Santis, R., Pucillo, L.P., Colizzi, V., Vendetti, S. 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(2004) Journal of Leukocyte Biology, 76 (4), pp. 827-834. 87. Vendetti, S., Riccomi, A., Sacchi, A., Gatta, L., Pioli, C., De Magistris, M.T. Cyclic adenosine 5′-monophosphate and calcium induce CD152 (CTLA-4) up-regulation in resting CD4+ T lymphocytes. (2002) Journal of Immunology, 169 (11), pp. 6231-6235. 88. Cappelli, G., Volpe, P., Sanduzzi, A., Sacchi, A., Colizzi, V., Mariani, F. Human macrophage gamma interferon decreases gene expression but not replication of Mycobacterium tuberculosis: Analysis of the host-pathogen reciprocal influence on transcription in a comparison of strains H37Rv and CMT97. (2001) Infection and Immunity, 69 (12), pp. 7262-7270.