Optional group:
OPZIONALI - (show)
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12
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20401656 -
BIOGEOGRAPHY
(objectives)
AFTER THE COURSE, THE STUDENTS SHOULD BE ABLE TO: 1) DISCUSS THE HISTORICAL AND ECOLOGICAL FACTORS THAT AFFECTED THE GEOGRAPHICAL DISTRIBUTION OF ANIMALS AND PLANTS; 2) FORMULATE HYPOTHESES AND MODELS EXPLAINING THE SHAPE, SIZE AND POSITION OF THE GEOGRAPHIC RANGE OF A TAXON; 3) DISCUSS EVENTS OF RANGE EXPANSION OR CONTRACTION, DUE TO CLIMATIC CHANGES OR HABITAT TRANSFORMATION CAUSED BY HUMAN ACTIVITIES; 4) DESCRIBE THE FAUNA, FLORA AND VEGETATION OF EACH CONTINENT, IN RELATION TO PAST AND PRESENT GEOGRAPHICAL AND ECOLOGICAL FACTORS; 5) BUILD PREDICTIVE MODELS FOR BIODIVERSITY CONSERVATION AND MANAGEMENT, IN CONNECTION WITH CLIMATE CHANGES AND LANDSCAPE ALTERATION.
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6
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BIO/05
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48
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20410278 -
MICROBIOLOGIA AMBIENTALE
(objectives)
1. acquire knowledge of the fundamental role of microorganisms in ecosystems and of the factors affecting their distribution and interactions with other organisms:
- metabolic and functional biodiversity, structure and dynamics of microbial communities
- bacteria and archea taxonomic groups
2. knowledge of traditional, molecular and cultivation-independent methods for identification/typing and analysis of microbial populations
3. evaluation of the multiple potential applications of environmental microorganisms also as bioindicators
4. acquisition of critical skills by reading scientific articles
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DALMASTRI Claudia
( syllabus)
1. Evolution and systematic of microorganisms
Origin of bacteria; molecular phylogenesis; 16S rRNA gene and evolution; basis of microbial systematic
2. Metabolic diversity of microbes
Chemolitotrophy; fermentation; anaerobiosis; phototrophy
3. Functional diversity of microbes
Phototrophic and chemotrophic bacteria; bacteria in sulfur and nitrogen cycles
4. The principal phylogenesic groups of Bacteria
Proteobacteria, Firmicutes, Bacteroidetes, Ipertermofili
5. The principal phylogenetic groups of Archea
Phyla and evolution
6. Methods in microbial ecology
Culture-based methods; functional analysis
Cultivation-independent techniques: microscope; genetic analysis; genome and metagenomics
7. Microbial ecosystems
Principles of ecology
Microbe environment: microbial interactions (Quorum sensing; Biofilm)
Terrestrial environment: soil
Aquatic environment: lakes, oceans
Extreme environments (deep sea; hydrothermal springs)
8. Microbial role in nutrient cycles
Carbon, nitrogen, sulfur, others
9. Symbiosis between microorganisms and between microorganisms and different organisms
Plants; rhizosphere; root nodules
Mammals; microbiome: bowel and rumen
10. Microorganisms in anthropized environments
Bioremediation of contaminated sites; water treatment; biocorrosion; mineral recovery from mines
( reference books)
Text book: Madigan et al., Brock Biology of microorganisms 14th edition
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6
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BIO/19
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44
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5
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20410259 -
ENTOMOLOGIA
(objectives)
The main formative targets are: 1) the acquisition of a basic knowledge on morphology, anatomy, physiology and evolution of the main insect groups. 2) the acquisition of both theoretical and practical knowledge on systematics and classification of the hexapoda. 3) the construction of a solid cultural background for an advanced discussion on causes and effects of the amazing evolutionary success and diversity of insects and on their importance in basic and applied studies. 4) the acquisition of the tools for the insect taxonomic identification, expecially for those orders and families present in the italian fauna. 5) to stimulate the curiosity and the ability of critically observe the nature. 6) the self-evaluation by the student of the competence whitin the animal biology, and in particular in the entomology.
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DI GIULIO ANDREA
( syllabus)
1) Introduction: aim of the course; entomology in the history of Zoology and more generally in the history of science; role of entomology in modern biological disciplines; basic and applied entomology; relationships of insects with man and the environment.
2) Generalities on Arthropods; phylogenesis problems of Arthropods; insects in the evolution of terrestrial Arthropods; general information on the Atelocerata, and in particular on the Hexapods; outline of paleontology of insects; insect origin; significance of the evolutionary success of insects.
3) Insects as land animals; exoskeleton; structure of the integument and cuticle; chemical and physical colors. External anatomy: regions of the body; sclerites; primary and secondary segmentation; appendices and wings.
4) Movement: musculature and endoskeleton; the race; the jump; origin and mechanics of flight; adaptations to aquatic life and importance of surface forces, swimming; the excavation; raptorial and phoretic limbs.
5) Breathing; breathing in the aquatic environment; water reabsorption; excretion; adaptations to temperature changes.
6) Nutrition: cephalic appendages and mouthparts; anatomy and physiology of the digestive system; food strategies.
7) Circulatory system.
8) Reproduction: structure and functional morphology of the segments and genital appendages; reproductive systems and reproductive behaviors; parthenogenesis; pedogenesis; polyembryony; meaning of heterogony; eggs; sperm.
9) Embryonic and postembryonic development: growth and metamorphosis; types of larvae and types of metamorphosis; diapause; physiology; endocrine glands.
10) Communication in insects. Nervous system: components and functioning. Endocrine system: hormones and endocrine organs. Exocrine glands. Perception of the environment. Compound eyes. Vision. Ocelli. Mechanoreceptors. Coloration. Light production. Mechanical communication: production of sound and vibrations of the substrate. Chemical communication: pheromones and secretions of interspecific significance.
11) Intraspecific relationships; parental care; society; interspecific relationships; predation; parasitism.
12) Orientation; migrations; dispersion.
13) Classification: diagnostic characters at the level of orders and outline of the most important families, with particular regard to the Italian fauna and the aspects of biology and ecology. Phylogeny of insects.
Esapodi Apterigoti: COLLEMBOLA, PROTURA, DIPLURA, MICROCORYPHIA, ZYGENTOMA. Paleotteri: EPHEMEROPTERA, ODONATA. Polineotteri (orthopteroid orders): PLECOPTERA, EMBIOPTERA, DICTYOPTERA, ISOPTERA, GRYLLOBLATTODEA, DERMAPTERA, PHASMIDA, ORTOPTERA, ZORAPTERA, MANTOFASMATODEA. Paraneoptera (emitteroid orders): PSOCOPTERA, PHTHIRAPTERA, THYSANOPTERA, HETEROPTERA. Homoptera. Oligoneotteri: MECOPTERA, TRICHOPTERA, LEPIDOPTERA, DIPTERA, SIPHONAPTERA, MEGALOPTERA, RAPHIDIOPTERA, PLANIPENNIA, COLEOPTERA, STREPSIPTERA, HYMENOPTERA.
14) Aspects of applied entomology: medical entomology, agricultural entomology, entomology in environmental assessment, insect conservation, urban entomology, veterinary entomology, entomology applied to conservation of cultural heritage.
( reference books)
P.J. Gullan & P.S. Cranston “Lineamenti di Entomologia” Zanichelli
R.G. Davies “Lineamenti di Entomologia” Zanichelli
G. Grimaldi “Evolution of the Insects”
R.F. Chapman “The Insects: structure and function” Hodder & Stoughton, London
C. Gillot “Entomology” Plenum Press, New York
O.W. Richards & R.G. Davies “Imm’s general textbook of entomology” Chapman & Hall, London Vol. I e II
M. Chinery “Guida agli insetti d’Europa” Muzzio
Office Hours: every day of the week by appointment by email (andrea.digiulio@uniroma3.it)
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6
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BIO/05
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32
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20
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20401676 -
FRESH WATER ECOLOGY
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20410284 -
PARASSITOLOGIA EVOLUZIONISTICA
(objectives)
Offering the students a new perspective in the study of parasitology, by means of an ecological, evolutionary and comparative approach. the intimate and intricate nature of the association between hosts and parasites, has traditionally been studied by giving emphasis on its pathogenicity for non-human and human animal hosts. in contrast, this course offers the student the opportunity to deepen topics such as adaptive strategies of parasitic life-style, the impact of parasitism on the community structure or else the role of a parasite in the trophic energy transfer in the community. emphasis will be given to the host as key element in the parasite environment and, as such, its important role as a selective pressure
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6
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BIO/05
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40
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10
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20402025 -
Bioindication and Environmental Monitoring
(objectives)
Acquisition of specific knowledge on bioindication and its applications, particularly with regard to plant and animal organisms used as biological indicators of the environmental status. Knowledge of the experimental methods and data processing for the environmental monitoring.
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6
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BIO/02
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44
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5
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20402508 -
NATURAL PRODUCTS AND ENVIRONMENTAL CHEMISTRY
(objectives)
THE COURSE AIMS AT GIVING:
1) A GENERAL KNOWLEDGE OF THE BIOSYNTHETIC PATHWAYS OF SECONDARY METABOLISM;
2) INFORMATION ABOUT THE MAIN NATURAL PRODUCTS DERIVED FROM MICROORGANISM, PLANTS AND ANIMALS AND THEIR ROLE IN NATURAL ENVIRONMENT;
3) KNOWLEDGE ON THE STRUCTURE/BIOLOGICAL ACTIVITY RELATIONSHIP OF THE MAIN SECONDARY METABOLITES USED IN PHARMACEUTICAL AND HEALTHCARE INDUSTRY.
4) ATTAINMENT OF THE BASIC EDUCATIONAL BACKGROUND NECESSARY TO UNDERSTAND THE CHEMICAL EQUILIBRIA THAT REGULATE THE ORIGINS, THE TRANSPORT, THE TRANSFORMATIONS AND THE EFFECTS OF THE ENVIRONMENTAL CHEMICAL SPECIES, EITHER OF NATURAL OR HUMAN ORIGIN.
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TOFANI DANIELA
( syllabus)
INTRODUCTION TO NATURAL PRODUCTS CHEMISTRY. MAIN FEATURES OF SECONDARY METABOLISM.
ACETATE PATHWAY. PROSTAGLANDINS, AROMATIC POLYKETIDES, ANTHRAQUINONES, CANNABINOIDS, AFLATOXINS.
SHIKIMATE PATHWAY. SHIKIMIC ACID BIOSYNTHESIS. CINNAMIC ACIDS. LIGNINES. PHENYLPROPANOIDS. BENZOIC ACIDS. COUMARINS. FLAVONOIDS. TANNINS. ISOFLAVONES. TERPENOID QUINONES.
MEVALONATE PATHWAY. MEVALONIC ACID BIOGENESIS. BIOSYNTHESIS OF DIFFERENT CLASSES OF TERPENES. IRIDOIDS. GIBBERELLINS. HORMONES. ANIMAL AND HUMAN STEROIDS. PHYTOSTEROLS.
ALKALOIDS: DEFINITION AND NOMENCLATURE. BIOSYNTHESIS AND BIOLOGICAL ACTIVITY OF THE MAIN CLASSES OF NATURAL ALKALOIDS: COCAINE, NICOTINE, CURARE, MORPHINE, LOGANIN, LYSERGIC ACID, CONIINE.
CARBOHYDRATES: GENERALITIES. CYANOGENIC GLYCOSIDES. STREPTOMYCINS.
PEPTIDIC SECONDARY METABOLITES. INTERFERONS. OPIOID PEPTIDES. PEPTIDE TOXINS: RICIN AND BOTULIN. PENICILLINS.
INTRODUCTION TO ENVIRONMENTAL CHEMISTRY. THE SPHERES IN WHICH THE EARTH IS DIVIDED.
THE ATMOSPHERE: OZONE LAYER FORMATION AND DEPLETION; CFCS AND HALONS. OXIDANT AND POLLUTANTS SPECIES. THE GREENHOUSE EFFECT. THE KYOTO’S PROTOCOL.
THE HYDROSPHERE: PHYSICAL AND CHEMICAL PROPERTIES OF WATER AND WATER BODIES. TIC, TOC, TC. EASY TO OXIDIZE ORGANIC POLLUTANTS (COD, BOD5) AND PERSISTENT ORGANIC POLLUTANTS (POP). SHORT AND LONG TERM TOXICITY (LD50 AND LOD50). NOEL AND ADI.
BIOACCUMULATION AND BIO-MAGNIFICATION. METABOLISM OF A FEW PESTICIDES.
( reference books)
P.M. DEWICK : MEDICINAL NATURAL PRODUCTS. A BIOSYNTHETIC APPROACH. THIRD EDITION. WILEY..
C. BAIRD, M. CANN “ENVIRONMENTAL CHEMISTRY”, FIFTH EDITION.
SLIDES OF THE LESSONS AND ADDITIONAL MATERIAL (PW PROTECTED) ARE AVAILABLE ON LINE AT THE ADDRESS: HTTP://HOST.UNIROMA3.IT/CENTRI/CISDIC/INDEX.HTM
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6
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CHIM/06
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48
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20410301 -
ECOLOGIA E GESTIONE DEGLI ECOSISTEMI COSTIERI
(objectives)
Major goals of this course are: to acquire an appropriate knowledge of the biodiversity and of general principles of the ecology of coastal ecosystems and their relationship with other ecological branches (plant and animal ecology). Other goal of this course is the growth of a thorough interest to ecological problems discussing the relationship between man and nature focusing in the coastal environment, analyzing main disturbance factors. The course is also intended to develop basic insights for the acquisition (sampling and monitoring), organization and interpretation of ecological data recorded in coastal ecosystems.
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ACOSTA ALICIA TERESA ROSARIO
( syllabus)
Ecology and plant diversity of coastal ecosystems
Coastal ecosystems, the transition between land and sea. Environmental gradients. Ecotones and transitions. Plant diversity in coastal, rocky and lagoon coastal environments. Major features and distribution throughout the world. Plant communites in Italy and Europe (Mediterranean and Atlantic). Analyses of main plant communities and habitats (European Directive 92/43/EEC (Habitat Directive) present in Italy. Conservation problems. Sampling tecniques and data analyses.
Ecologia e diversità faunistica delle coste sabbiose, delle lagune costiere e delle coste rocciose
The animal communities of coastal dunes and their ecological relations with plants. Interactions between the animal communities of coastal dunes and Mediterranean evergreen scrub. The fauna of coastal wetlands and their importance as sites of bird nesting and winter refuges. The Ramsar Convention: conservation and management issues in wetlands. Stranding and recovery of marine vertebrates (whales, dolphins and sea turtles). Nesting of sea turtles and their conservation. Coexistence of marine and land animals in the intertidal zone. Fauna of tide pools. Sea bird nesting on rock cliffs: conservation and management issues.
Conservation and management of coastal ecosystems
Conservation of coastal ecoystems. Disturbance factors. The role of disturbance on coastal ecosystems. Response to disturbance. Endangered species. Alien species. Bioindicators. Environmental quality and conservation status. Conservation and Management.
( reference books)
Acosta A. & Ercole S. 2017. Gli habitat delle coste sabbiose italiane: ecologia e problematiche di conservazione. Quaderni ISPRA (Istituto Superiore per la Protezione e la Ricerca Ambientale 215/2015.
Ruffo, S. (a cura di). (2002). Dune e spiagge sabbiose. Ambienti fra terra e mare. Quaderni Habitat, 4. Ministero dell’Ambiente e della Tutela del Territorio. Scaricabile dal sito del Ministero.
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CARPANETO GIUSEPPE
( syllabus)
Animal diversity and Ecology of coastal ecosystems
The animal communities of coastal dunes and their ecological relations with plants. Interactions between the animal communities of coastal dunes and Mediterranean evergreen scrub. The fauna of coastal wetlands and their importance as sites of bird nesting and winter refuges. The Ramsar Convention: conservation and management issues in wetlands. Stranding and recovery of marine vertebrates (whales, dolphins and sea turtles). Nesting of sea turtles and their conservation. Coexistence of marine and land animals in the intertidal zone. Fauna of tide pools. Sea bird nesting on rock cliffs: conservation and management issues.
( reference books)
POWER POINT FILES AND OTHER ELECTRONIC FILES, GIVEN BY THE PROFESSOR
The professor receives every day from 15:00 to 18:30 by appointment via email: giuseppe.carpaneto@uniroma3.it
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BIO/03
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16
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20
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Attività formative affini ed integrative
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| 2
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BIO/05
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16
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Attività formative affini ed integrative
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20410287 -
METODI E TECNICHE IN ECOLOGIA DELLA VEGETAZIONE
(objectives)
The acquisition of the knowledge on the main methods for the study of vegetation are assumed as formative objectives. in particular:
acquire the knowledge about main methods of vegetation study;
increase the ability to interpret the natural and artificial phenomena with particular attention to the plant landscape mechanisms;
develop the capacity of choice the most appropriate study and monitoring methodologies for conservation and management purposes;
implement the ability of interpretation of experimental data and scientific articles in the fields of plant ecology, geobotany and applied ecology.
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CUTINI MAURIZIO
( syllabus)
DEFINITION AND PROPERTIES OF PLANT COMMUNITIES. STRUCTURAL AND PHYSIOGNOMICAL CHARACTER OF VEGETATION. DISCRETE AND CONCRETE COMMUNITIES. ZONES AND BANDS OF VEGETATION. CONCEPT OF ZONALITY, AZONALITY AND EXTRAZONALITY. VEGETATION DYNAMICS AND POTENTIAL NATURAL VEGETATION.
GROWTH FORMS AND PLANT TRAITS. ANALYSES OF THE FUNCTIONAL DIVERSITY AND GRIME’S STRATEGIES (C-S-R). DIVERSITY ANALYSES: GENERAL CONCEPT, ALGORITHMS CALCULATION, RAREFACTION CURVE, ABUNDANCE/DOMINANCE RANK, RE’NY CURVES. SAMPLING METHODS OF THE PLANT COMMUNITIES (RANDOM AND SYSTEMATIC SAMPLING). SIZE AND DISTRIBUTION OF SAMPLES. ABUNDANCE MEASURES. ORIGIN AND DEVELOPMENT OF THE PHYTOSOCIOLOGY AND SYMPHYTOSOCIOLOGY.
GENERAL CONCEPT OF THE VEGETATION MAPPING. VEGETATION AND HABITAT INTERPRETATION (EUNIS AND ALL. I OF THE 92/43/CEE DIRECTIVE. HABITATS MONITORING, EUROPEAN AND NATIONAL RED LISTS OF HABITAT. MULTITEMPORAL ANALYSIS, ANTHROPIC IMPACT AND EFFECT OF VEGETATION.
( reference books)
BRECKLE S.W., 2002. Walter’s Vegetation of the Earth.Springer.
VAN DER MAAREL E. (Ed.), 2005. Vegetation Ecology. Blackwell Publishing.
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6
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BIO/03
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32
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20
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20410208 -
Biologia marina
(objectives)
The course is one of the optional training activities of the master’s degree in "Biodiversity and management of Ecosystems" and allows students to acquire a basic knowledge of Marine Biology and of the marine environment conservation, with a specific attention given to the Mediterranean Sea. Educational objectives of the course are: 1) to acquire basic skills of Oceanography, related to the physico-chemical factors and the movements of the Sea 2) to acquire basic skills related to the biology and adaptations of marine organisms, as well as the most important Mediterranean species and habitats of conservation interest and Mediterranean biogeography 3) to improve knowledge about monitoring and data collection techniques in the marine environment 4) to acquire the concepts and skills related to the critical issues existing in the Mediterranean Sea, and the tools available for its management and protection.
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Chiesa Stefania
( syllabus)
Part 1- Introduction to Marine Biology and Oceanography. Brief introduction to Marine Biology and Oceanography; origin and formation of the oceans; seabed and marine sediments; physical and chemical characteristics of the oceans; sea movements (currents, tides, waves); focus on the characteristics and circulation of the Mediterranean Sea.
Part 2-Life in the Sea. Adaptations of organisms to the marine environment; reproduction and life cycles; associations between organisms; benthos and the vertical zonation; plankton; nekton; deep Sea environments; transitional environments, with particular reference to coastal lagoons. Main Mediterranean species and habitats of conservation interest. Biogeography of the Mediterranean Sea.
Part 3- Sampling and monitoring methods in the marine environment. Main methods for monitoring and data collection in the marine environment; genetics and genomics of marine organisms: classical methods and new frontiers of genomics (environmental DNA and Next Generation Sequencing).
Part 4- The Mediterranean Sea and the current challenges for its management and conservation. Brief introduction to the Community Directives, the Strategies, and the financing programmes for the protection of the marine environment; Focus on “hot topics”: adaptation and resilience to climate change; introduction of alien species, tropicalization and meridionalization of the Mediterranean Sea; impact of plastics; fishing tools and over-exploitation of fish resources; environmental contaminants and their transfer from the abiotic to the biotic compounds.
( reference books)
1) Cognetti G., Sarà M., Magazzù G. - Biologia Marina. Edizioni Calderini, Roma, 1999. 596 pages; or further reprints. (in Italian)
2) Castro P., Huber M.E.- Marine Biology, 11th edition Mcgraw Hill Education, 2019 (in English).
LESSON SLIDES AND ADDITIONAL MATERIAL ARE PROVIDED DURING THE COURSE
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6
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BIO/07
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48
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20402360 -
CELLULAR BIOCHEMISTRY
(objectives)
THE COURSE PROPOSES TO OFFER FOR STUDENTS THE KNOWLEDGE RELATED TO "INORGANIC BIOFACTORS" IN ICEOSTASES, FROM THE BIOCHEMICAL ROLE IN ANALYZING THEIR IMPACT ON HEALTH HEALTH. LIKEWISE, THE COURSE PROVIDED STUDENTS WITH THE ESSENTIAL KNOWLEDGE ABOUT THE INCLUSION OF MOLECULES AND MOLECULES ON THE BASIS OF METABOLIC, MITOCONDRIAL AND NEOPLASTIC DISEASES.
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Derived from
20402360 BIOCHIMICA CELLULARE in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 DI MASI ALESSANDRA, ASCENZI PAOLO
( syllabus)
HEME-PROTEINS. HEME METABOLISM AND RELATED DISEASES. HEME BIOSYNTHESIS AND RELATED DISEASES. IRON METABOLISM AND RELATED DISEASES. INORGANIC BIOFACTORS: OXYGEN, CARBON MONOXIDE, NITROGEN MONOXIDE, HYDROGEN SULFIDE. BIOCHEMICAL AND CELLULAR ROLES OF THE INORGANIC BIOFACTORS. ROLE IOF THE INORGANIC BIOFACTORS IN HUMANN DISEASES ONSET. THE THERAPEUTIC USE OF THE INORGANIC BIOFACTORS. REACTIVE OXYGEN AND NITROGEN SPECIES. MITOCHONDRIAL DISEASES. THE ENERGETIC MATTER OF CANCER CELLS. THE METABOLIC REQUIREMENTS OF CANCER CELLS: THE WARBURG EFFECT.
( reference books)
SCIENTIFIC PAPERS SUPPLIED BY THE TEACHER.
Support texts:
Siliprandi & Tettamanti "Biochimica Medica - strutturale, metabolica e funzionale" Ed. Piccin
- Chiurchiù & Maccarrone "I radicali liberi e la loro rilevanza in biomedicina: dai meccanismi molecolari alle prospettive terapeutiche" Ed Piccin
RECEPTION TIME: Monday 10 am
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6
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BIO/10
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48
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20410207 -
Biochimica della nutrizione
(objectives)
The Nutrition Biochemistry course is aimed at providing to the students the basic knowledge to understand the molecular mechanisms by which the human organism uses macro- and micro-nutrients to produce the energy needed to maintain the order which characterizes every living being.
In particular, the objectives of the course are the comprehension of the pathways through which the different groups of nutrients (carbohydrates, lipids, proteins, vitamins and minerals) and other substances of natural and non-natural origin (ethanol, stimulant beverages, xenobiotics) are assimilated and transformed in the human body, and how they influence its metabolic status.
Finally, one of the aims is also that of illustrating the production of reactive oxygen species linked to metabolism and the protective role exerted by antioxidant compounds of dietary origin.
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6
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BIO/10
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48
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20401653 -
BIOCHEMISTRY AND MOLECULAR CLINICAL BIOLOGY
(objectives)
Main goals of the course are: i) to provide an overview of the activities of a clinical laboratory looking at the organizational context and current business; ii) to illustrate the various stages which are at the basis of main analytical methods, either molecular or biochemical, used in biomedical laboratories for modern diagnostic purposes; iii) to provide the key of Interpretation for the obtained results from a pathophysiological point of view. To promote a critical approach towards laboratori diagnosis.
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6
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BIO/12
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48
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20410253 -
NEUROBIOLOGIA CELLULARE APPLICATA
(objectives)
The aims of this course are: to gain knowledge of the specialized cellular architecture of glia and neurons; to deepen the knowledge of cellular and molecular mechanisms involved in cell communication between glia and neurons. Special emphasis will be given to nitric oxide-regulated pathways. in this course students can use state of the art equipment and learn current techniques employed in cell biology research labs. moreover students are allowed to critically discuss the scientific literature in the field of neurobiology.
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Derived from
20410253 NEUROBIOLOGIA CELLULARE APPLICATA in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 PERSICHINI TIZIANA
( syllabus)
Cultural knowledge: The aims of this course are: to gain knowledge of the specialized cellular architecture of glia and neurons; to deepen the knowledge of cellular and molecular mechanisms involved in cell communication between glia and neurons. Special emphasis will be given to nitric oxide-regulated pathways. In this course students can use state of the art equipment and learn current techniques employed in cell biology research labs. Moreover students are allowed to critically discuss the scientific literature in the field of glial cell biology.
Methodological skills: to know how to design an experiment using glial cell cultures, to acquire and analyze the data obtained from the laboratory activity.
Topics:
The course will deepen the following topics: morphology and ultrastructure of glial cells; Properties and functions of astrocytes; homeostasis of pH, K and volume; The neuro-glial-vascular unit, mechanism of cerebral blood flow regulation; gliotransmitters release and the tripartite synapse; The role of nitric oxide as neurotransmitter and neurotoxic factor; Microglia: activation, motility and immune surveillance; Reactive astrocytosis, neurodegenerative and infectious diseases. Cellular response to oxidative stress. The laboratory activity will be mainly devoted to the study of nitric oxide as cellular messenger in glial cell cultures. Experimental procedures include but are not limited to the following: Preparation of whole, cytoplasmic and nuclear extracts, Western Blot; Analysis of gene expression and transcription factor activation (RNA extraction, RT-PCR, EMSA, TransAM-ELISA); Modulation of gene expression (Oligo-Decoy); Cell Transfection; Analysis of nitric oxide (NO) pathway and determination of NO in living cells and in cell extracts.
( reference books)
BRUCE R. RANSOM, HELMUT KETTENMANN. “NEUROGLIA”
– THIRD EDITION – 2012 OXFORD UNIVERSITY PRESS
Slides in PDF format of all the lectures will be provided by the teacher.
The teacher receives the students at least once a week by appointment via e-mail: tiziana.persichini@uniroma3.it
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6
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BIO/06
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32
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20
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20402204 -
BIO-ORGANIC CHEMISTRY
(objectives)
The course will address the chemical transformations shared by organic chemistry and biological systems. Indeed, although the functional group elaborations are formally the same, the followed reaction pathways result to be quite different with respect to the experimental conditions of both organic syntheses and biological processes. In such a context, the enzymatic action modes in living systems will be compared with the key role performed by temperature, pressure, pH, catalysts and solvents. Keeping this in mind, a few of the most well-known chemical reaction mechanisms will be studied, underlining, step by step, the main similarities and distinctions with the analogous biological transformations
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6
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CHIM/06
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48
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20402369 -
MICROBIAL GENETICS
(objectives)
The main educational goal of the genetics of microorganisms course is to provide students with knowledge on: 1) the prokaryotic genome and the mechanisms that ensure its replication, transcription, translation and integrity throughout generations; 2) the regulation mechanisms of the genetic expression in bacteria; 3) the mechanisms responsible for horizontal gene transfer (conjugation, transformation and transduction); 4) the molecular basis of cellular differentiation and adaptive response. students will also acquire basic knowledge on genetic engineering and omic approaches to study microbial communities.
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Derived from
20401664 GENETICA DEI MICRORGANISMI in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 N0 IMPERI FRANCESCO
( syllabus)
The course aims at providing to the student:
- adequate knowledge and understanding on advanced methodologies in bacterial genetics, appropriate methodologies and communication skills for the study of genotype-phenotype relationships in bacteria;
- adequate applied knowledge for the evaluation and drafting of experimental approaches, and for retrieving and critically reviewing relevant scientific literature from on-line databases (making judgements).
Programme
- structure, organization, functioning and evolution of the bacterial chromosome;
- methods for the sequencing and analysis of bacterial genomes;
- structure, organization, function and evolution of mobile genetic elements (plasmids and transposons);
- genetic and molecular bases of horizontal gene transfer;
- genetic and molecular bases of gene expression regulation and bistability in bacteria;
- genetic bases and experimental approaches for the study of antibiotic resistance and tolerance;
- methods for the identification and validation of essential genes;
- approaches for the identification and study of unculturable microorganisms
( reference books)
Selected topics will be available on suggested Bacterial Genetics books, as indicated in the following reference list. Specific research papers and experimental protocols will be provided during theoretic lessons on advanced research topics and laboratory practices.
Innovative teaching will be promoted by sharing power-point presentations illustrating the main topics of the course via email. Moreover, students will be encouraged to make use of web-based resources and databases to autonomously increase their knowledge on specific advanced topics.
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BIO/18
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20410314 -
GENETICA DEI SISTEMI COMPLESSI
(objectives)
The course aim to provide a wider and deeper outlook of genetics topics not addressed in the course of genetics. special attention will be paied to the role of human genome (and epigenome) in the regulation of complex biological processes and in the individual response to endogenous and exogenous factors.
-
Derived from
20410314 GENETICA DEI SISTEMI COMPLESSI in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 Berardinelli Francesco
( syllabus)
GENOME (ORGANIZATION, STRUCTURE AND FUNCTION, THE EXOME AND THE GENETIC REGULATION OF GENE TRANSCRIPTION). EPIGENOME (METHYLATION, HISTONE CODE, CHROMATIN 3D ARCHITECTURE, NON-CODING RNA). GENETIC MECHANISMS OF SEX DETERMINATION (HOW DOES SEX IS GENETICALLY DETERMINED, INACTIVATION OF X CHROMOSOME, SEX-DEPENDENT PHONOTYPIC EFFECTS). CELL CYCLE REGULATION. GENETIC OF AGING (GENETIC THEORIES OF AGING, GERONTOGENES AND GENES INVOLVED IN LONGEVITY, AGING IN ANIMAL MODELS, MOLECULAR AND CELLULAR AGING). CANCER GENETICS (ONCOGENES, ONCO-SUPPRESSOR GENES, CHROMOSOMAL REARRANGEMENTS INVOLVED IN CANCER, THE CANCER STEM CELLS THEORY). INDIVIDUAL GENETIC RESPONSE AND PHARMACOGENETICS.
( reference books)
- SCIENTIFIC ARTICLES AND DISPENSES PROVIDED BY THE PROFESSOR
- TOM STRACHAN E ANDREW READ, GENETICA MOLECOLARE UMANA, ZANICHELLI
- MICHEAL R. CUMMINGS, EREDITA’ PRINCIPI E PROBLEMATICHE DELLA GENETICA UMANA, EDISES
- DANIEL L. HARTL ED ELIZABETH W. JONES, GENETICA ANALISI DI GENI E GENOMI, EDISES
- M.A. JOBLING, M.E. HURLES E C. TYLER-SMITH, HUMAN EVOLUTIONARY GENETICS, GARLAND SCIENCE
The professor receives every Tuesday from 16.00 to 17.00 by appointment via email: francesco.berardinelli@uniroma3.it
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6
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BIO/18
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40
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10
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20401777 -
PUBLIC HEALTH
(objectives)
General objectives
At the end of the course the student will be able to design epidemiological studies to address public health problems and to identify activities to prevent chronic and infectious diseases.
Specific objectives
- to know the major mortality and morbidity indicators
- to identify the more appropriate epidemiological study to describe the burden of major diseases in the population and to assess the relation between diseases and possible risk factors associated to them
- to interpret epidemiological data
- to discuss the importance of the health education and health promotion
- to list and discuss problems related to water supply, sanitation and waste management
- to argue about necessary controls/monitoring to protect the environment and the community
- to design health promotion programmes
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6
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MED/42
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48
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20401821 -
IMMUNOLOGY
(objectives)
to deeply understand cellular and molecular mechanisms of immune response and their role in health and disease.
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Derived from
20401821 IMMUNOLOGIA in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 N0 , Coccia Eliana Maria
( syllabus)
Properties and Overview of Immune Responses: Cells and Tissues of the Immune System
Leukocyte Circulation and Migration into Tissues
Innate Immunity
Antigens and Antigen presentation
Immune Receptors and Signal Transduction
Lymphocyte T Development and Activation
Differentiation and Functions of CD4+ and CD8 +Effector T Cells
B Cell Activation and Antibody Production
Humoral Immunity
Immunologic Tolerance and Autoimmunity
Immunity to Microbes and Vaccines
Immunity to Tumors
Immunodeficiency and Immunosenescence
Pubmed research
( reference books)
- Abul K. Abbas, Andrew H. Lichtman, Shiv Pillai
IMMUNOLOGIA CELLULARE E MOLECOLARE
(9th edition, Edizioni Edra)
- Peter Parham
IL SISTEMA IMMUNITARIO
(2nd editio, Edizioni EdiSES)
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MED/04
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48
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20410270 -
LABORATORIO DI BIOTECNOLOGIE DEI MICRORGANISMI
(objectives)
The main aims of the course are:
a) acquisition of knowledge on advanced methodologies in microbial biotechnology;
b) acquisition of appropriate metodologies and languages for the isolation, observation and description of industrial microorganisms;
c) acquisition of basic knowledge for drafting and executing experimental protocols.
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Derived from
20410270 LABORATORIO DI BIOTECNOLOGIE DEI MICRORGANISMI in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 RAMPIONI GIORDANO, LEONI LIVIA
( syllabus)
The course aims at providing to the student:
- adequate knowledge and understanding on advanced methodologies in microbial biotechnology, appropriate methodologies and communication skills for the isolation, observation, description and engineering of industrial microorganisms;
- adequate applied knowledge for drafting and executing experimental protocols, and for retrieving and critically reviewing relevant scientific literature from on-line databases (making judgements).
Programme
During the laboratory practices and the corresponding theoretic lessons, the following topics will be covered:
- isolation of microorganisms of industrial relevance from the environment, preparation of growth media and cultivation techniques;
- transposon–based mutagenesis (generation and screening of mutant libraries);
- genetic transfer processes (conjugation and transformation);
- use of whole-cell bacterial biosensors for gauging specific molecules produced by other microorganisms.
The following topics will be covered in additional theoretic lessons:
- development of innovative therapeutic strategies based on biotechnological processes;
- development of biosensors and reporter systems for the identification of new drugs;
- application of synthetic biology to microbial biotechnology;
- properties of the regulatory networks and their application to biotechnological processes.
( reference books)
Selected topics will be available on suggested Microbiology and Microbial Biotechnology books, as indicated in the following reference list. Specific research papers and experimental protocols will be provided during theoretic lessons on advanced research topics and laboratory practices.
Innovative teaching will be promoted by cloud-sharing of power-point presentations illustrating the main topics of the course. Moreover, students will be encouraged to make use of web-based resources and databases to autonomously increase their knowledge on specific advanced topics.
Students will be received every Monday, from 3:00 to 4:00 pm. Students can be received at the best of their convenience if an appointment has been fixed at the end of the lessons or by email.
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CHIM/11
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30
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20410273 -
NEUROBIOLOGIA DELLO SVILUPPO
(objectives)
Aim of the course is to provide students with advanced knowledge of developmental biology, focussing on vertebrate nervous system. cellular and molecular mechanisms underlying neural differentiation and morphogenesis will be addressed in different in vivo and in vitro models. the role of neurogenesis and plasticity throughout the lifespan of individuals will be examined. students will be able to: 1) describe major neural processes in vertebrates; 2) identify molecular pathways driving stem cells to neuronal or glial cell fates; 3) correlate abnormal cellular processes with specific neurodevelopmental or age-related disorders.
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6
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BIO/06
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40
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10
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20410212 -
Genetica umana applicata
(objectives)
1. Consolidare le conoscenze di Genetica Umana acquisite nei corsi di base facendo riferimento in particolare ai meccanismi biologici alla base degli stati patologici in Genetica Umana
2. Portare i concetti acquisiti su un piano pratico e applicativo attraverso la conoscenza delle stategie e delle metodiche utilizzate nei laboratori diagnostici.
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6
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BIO/18
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24
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30
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20410213 -
Nutrienti di origine vegetale
(objectives)
Origin of agriculture and plant domestication. characteristics of the main crops: poaceae, fabaceae, rosaceae, solanaceae, brassicaceae. nutritional values of the different plant organs and nutrients bioavailability. primary and secondary metabolism. nutrients from plants: proteins, lipids and oils, carbohydrates, fibers, minerals, vitamins and antioxidants. nutritional values of secondary metabolism and bioactive compounds: terpenes, phenols, alkaloids, cyanogenic glucosides, glucosinolates, non-protein amino acids. effects of the environmental conditions on primary and secondary metabolism: food quality and production of aromas, flavors and toxins. plant bioactive compounds as dietary supplements. effects of storage conditions and pre- and post-harvest diseases on nutritional quality of plant foods. allergy and intolerances caused by plant substances in crop species. genetic improvement and biotechnology approaches to develop crop plants resistant to environmental stress with high nutritive contents.
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Derived from
20410213 Nutrienti di origine vegetale in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 CONA ALESSANDRA
( syllabus)
The main objective of the course is to provide basic knowledge on the main nutrients present in different food plants, such as carbohydrates, lipids and proteins. Specific attention is paid to the biochemical plasticity of secondary metabolism that leads to the formation of both secondary metabolites and bioactive compounds with beneficial effects on human health and anti-nutritional or toxic factors.
Origin of agriculture and plant domestication. Characteristics of the main crops: Poaceae, Fabaceae, Rosaceae, Solanaceae, Brassicaceae. Nutritional values of the different plant organs and nutrients bioavailability. Primary and secondary metabolism. Nutrients from plants: proteins, lipids and oils, carbohydrates, fibers, minerals, vitamins and antioxidants. Nutritional values of secondary metabolism and bioactive compounds: terpenes, phenols, alkaloids, cyanogenic glucosides, glucosinolates, non-protein amino acids. Effects of the environmental conditions on primary and secondary metabolism: food quality and production of aromas, flavors and toxins. Plant bioactive compounds as dietary supplements. Effects of storage conditions and pre- and post-harvest diseases on nutritional quality of plant foods. Allergy and intolerances caused by plant substances present in crop species. Genetic improvement and biotechnology approaches to develop crop plants with high nutritive contents and resistant to environmental stress.
( reference books)
1. Piante alimentari. Biologia, composizione chimica, utilizzazione. Rinallo C.; Piccin.
2. Biologia delle Piante. Vol 2: Interazioni con l’ambiente e Domesticazione. Smith A. M. et al.; Zanichelli.
3. Lecture notes and scientific articles provided by the teacher
The professor receives every day by appointment via e-mail: alessandra.cona@uniroma3.it
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BIO/04
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20402377 -
GENERAL PATHOLOGY
(objectives)
The aims of the course are: to know the aetiology and the molecular mechanisms of the human diseases; to know how to interpret the pathophysiological mechanisms of the human diseases
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MED/04
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48
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20410319 -
FISIOLOGIA CELLULARE E MOLECOLARE
(objectives)
The course aims to deliver knowledge on some aspects of the regulation of cellular function on the basis of the most recent published works.
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BIO/09
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40
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10
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20402518 -
TOXICOLOGY
(objectives)
THE COURSE AIMS TO PROVIDE PRECISE INFORMATION ON THE TOXICODYNAMIC AND TOXICOKINETIC MECHANISMS THAT ARE BEHIND THE TOXIC EFFECTS PRODUCED BY DIFFERENT NATURAL AND SYNTHESISED XENOBIOTICS, AND ON THE PROCESS OF EVALUATION OF TOXICOLOGICAL RISKS.
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Derived from
20402518 TOSSICOLOGIA in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 N0 TREZZA VIVIANA
( syllabus)
GENERAL PRINCIPLES. AIMS AND FIELDS OF TOXICOLOGY. CLASSIFICATION OF TOXIC AGENTS. MECHANISMS OF MOLECULAR AND CELL TOXICITY. RISK EVALUATION. TOXICOKINETICS: ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF TOXIC AGENTS. ADVERSE DRUG REACTIONS, DRUG INTERACTIONS AND PRINCIPLES OF PHARMACOVIGILANCE. ANTIDOTES AND THEIR CLASSIFICATION. EXPERIMENTAL EVALUATION OF TOXIC EFFECTS IN IN VITRO AND IN VIVO MODELS AND DATA EXTRAPOLATION. SYSTEM AND ORGAN TOXICOLOGY. DEVELOPMENTAL AND FEEDING TOXICOLOGY. CLASSES OF TOXIC COMPOUNDS: METALS, PHYTODRUGS, NATURAL TOXINS. PSYCHOACTIVE AND DOPING DRUGS.
( reference books)
CASARETT & DOULL'S “ESSENTIALS OF TOXICOLOGY”, SECOND EDITION, MCGRAW HILL
Power-point files of the lessons will be provided
To get an appointment with the Professor, email to: viviana.trezza@uniroma3.it
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BIO/14
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20410321 -
VIROLOGIA ANIMALE GENERALE ED APPLICATA
(objectives)
Deepening the knowledge about animal viruses (origins, classification, replicative strategies, virulence, immunoevasion mechanisms) and their applications (antiviral vaccines, viral vectors for gene expression, oncolytic viruses).
-
Derived from
20410321 VIROLOGIA ANIMALE GENERALE ED APPLICATA in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 AFFABRIS ELISABETTA
( syllabus)
The course describes and compares the replication cycles of different animal viruses that infect vertebrate hosts to gain insight into: origin of viruses, structure, evolution, virus-cell interactions, host defense mechanisms and strategies of viral immunoevasion, methods of detection, identification and titration, antiviral drugs and profilaxis of viral infections. In particular, it will be described viruses of the following viral families: picornaviridae, ortomixoviridae, paramixoviridae, rabdoviridae, retroviridae, hepadnaviridae, flaviviridae, parvoviridae, poliomaviridae, papillomaviridae, adenoviridae, herpesviridae, poxviridae. In addition, introduction to applied virology will be provided (i.e., vaccine development, viral vectors and oncolytic viruses). Students will be able to apply the acquired knowledge to understand in-depth texts and experimental data related to the discipline.
( reference books)
WHERE TO STUDY:
Adopted text book:
- N. J. Dimmock, A. J. Easton, K. N. Leppard - Introduction to Modern Virology - Seventh edition 2016 -Wiley Blackwell - ISBN 978-1-119-97810-7
Mandatory integrations regarding viral vectors (adenoviral, adeno-associated, retroviral and lentiviral vectors, poxvirus-based vectors) and oncolitic viruses (general introduction + oncolytic adenoviruses):
- Fields virology, Vth edition, 2007- D.M.Knipe and P.M.Howley editors-in-chief -Lippincot Williams & Wilkins publishers, cap.16 Viral vectors and their applications
- Stéphanie Durand and Andrea Cimarelli - The Inside Out of Lentiviral Vectors - Viruses 2011, 3, 132-159.
The detailed list of topics covered during the lessons and PDF of power point presentations used during the course are available upon request.
Office hours by appointment via email (elisabetta.affabris@uniroma3.it) or at the end of the lessons.
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BIO/19
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20410305 -
LABORATORIO DI MICROSCOPIA ELETTRONICA
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II Modulo
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3
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BIO/05
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8
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20
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Università Roma Tre